2. Gene
  3. DOCK1 - dedicator of cytokinesis 1 Gene

DOCK1 - dedicator of cytokinesis 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ced5; DOCK180

Gene ID: 1793 | Gene type: protein coding

About DOCK1

Cytogenetic location: 10q26.2 Genomic coordinates (GRCh38): 10:126,905,428-127,452,516 (from NCBI)

This gene has 6 transcripts (splice variants), 226 orthologues and 10 paralogues. Ubiquitous expression in thyroid (RPKM 10.9), skin (RPKM 10.0) and 24 other tissues.

Summary

This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

DOCK1 Products(14)

mRNA Protein Name
NM_001290223.2 NP_001277152.2 dedicator of cytokinesis protein 1 isoform 1
NM_001377543.1 NP_001364472.1 dedicator of cytokinesis protein 1 isoform 3
NM_001377544.1 NP_001364473.1 dedicator of cytokinesis protein 1 isoform 4
NM_001377546.1 NP_001364475.1 dedicator of cytokinesis protein 1 isoform 5
NM_001377547.1 NP_001364476.1 dedicator of cytokinesis protein 1 isoform 6
NM_001377548.1 NP_001364477.1 dedicator of cytokinesis protein 1 isoform 7
NM_001377550.1 NP_001364479.1 dedicator of cytokinesis protein 1 isoform 8
NM_001377553.1 NP_001364482.1 dedicator of cytokinesis protein 1 isoform 9
NM_001377554.1 NP_001364483.1 dedicator of cytokinesis protein 1 isoform 10
NM_001377556.1 NP_001364485.1 dedicator of cytokinesis protein 1 isoform 11
NM_001377558.1 NP_001364487.1 dedicator of cytokinesis protein 1 isoform 12
NM_001377560.1 NP_001364489.1 dedicator of cytokinesis protein 1 isoform 13
NM_001377561.1 NP_001364490.1 dedicator of cytokinesis protein 1 isoform 14
NM_001380.5 NP_001371.2 dedicator of cytokinesis protein 1 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
contributes to guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
12134158 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12134158 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of epithelial cell migration IMP
IMP: Inferred from mutant phenotype
19004829 GOA
involved in positive regulation of substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
19004829 GOA
involved in regulation of postsynapse assembly IDA
IDA: Inferred from direct assay
21900250 GOA
involved in regulation of postsynapse assembly IMP
IMP: Inferred from mutant phenotype
21900250 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17515907 GOA
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
21900250 GOA
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
21900250 GOA
part of guanyl-nucleotide exchange factor complex IDA
IDA: Inferred from direct assay
12134158 GOA
is active in postsynapse IDA
IDA: Inferred from direct assay
21900250 GOA
is active in postsynapse IMP
IMP: Inferred from mutant phenotype
21900250 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DOCK1 Protein Structure

SH3_9

SH3_9: Variant SH3 domain (16 - 65)

DOCK-C2

DOCK-C2: C2 domain in Dock180 and Zizimin proteins (420 - 619)

DHR-2

DHR-2: Dock homology region 2 (1427 - 1609)

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  • 1865 a.a.
Protein Preferred Names Protein Names

dedicator of cytokinesis protein 1

180 kDa protein downstream of CRK

DOCK1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
DOCK1 Q14185 DOCK5 Homo sapiens Q9H7D0-1
Anti Tag CoIP
32203420
Intra
DOCK1 Q14185 ELMO1 Homo sapiens Q92556
Anti Tag CoIP
15247908
Intra
DOCK1 Q14185 ELMO1 Homo sapiens Q92556
Pull Down
18768751
Intra
DOCK1 Q14185 ELMO1 Homo sapiens Q92556
Anti Tag CoIP
12134158
Intra
DOCK1 Q14185 ELMO1 Homo sapiens Q92556
Pull Down
15723800
Intra
DOCK1 Q14185 ELMO1 Homo sapiens Q92556
Anti Tag CoIP
18768751
Intra
DOCK1 Q14185 ELMO1 Homo sapiens Q92556
Anti Tag CoIP
15723800
Intra
DOCK1 Q14185 ANKRD28 Homo sapiens O15084
Anti Tag CoIP
19118547
Intra
DOCK1 Q14185 GRB2 Homo sapiens P62993
Y2H Pooling
20936779
Intra
DOCK1 Q14185 RAC1 Homo sapiens P63000
Pull Down
12134158
Intra
DOCK1 Q14185 RAC1 Homo sapiens P63000
Pull Down
15723800
Intra
DOCK1 Q14185 RAC1 Homo sapiens P63000
Anti Tag CoIP
12134158
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Chromosome 10q26 Deletion Syndrome

Distal 10q Deletion Syndrome

Terminal Chromosome 10q26 Deletion Syndrome

Distal Monosomy 10q

Monosomy 10qter

Telomeric Deletion 10q

Distal Deletion 10q

10q26 Deletion Syndrome

10qter Deletion

Telomeric Deletion 10
Immunodeficiency 40

Dock2 Deficiency

IMD40

Immunodeficiency, Type 40
Spinocerebellar Ataxia, Autosomal Recessive 15

Autosomal Recessive Spinocerebellar Ataxia 15

SCAR15

Salih Ataxia

Autosomal Recessive Cerebellar Ataxia-Epilepsy-Intellectual Disability Syndrome Due To Rubcn Deficiency

Autosomal Recessive Spinocerebellar Ataxia Type 15

Spinocerebellar Ataxia, Autosomal Recessive, 15

Ataxia, Spinocerebellar, Autosomal Recessive, Type 15
Stereotypic Movement Disorder

Stereotypy Habit Disorder

Stereotyped Repetitive Movements

Stereotyped Disorder

Stereotypes Nos

Stereotype Habit Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-136177 Tris(2,4-di-tert-butylphenyl)phosphate Inhibitor 99.81% Unkown
HY-124711 TBOPP Inhibitor 99.96% Unkown
HY-RS03921 DOCK1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus DOCK1 VGNC VGNC:28154
Macaca mulatta DOCK1 VGNC VGNC:71965
Mus musculus DOCK1 MGD MGI:2429765
Rattus norvegicus DOCK1 RGD RGD:1566072
Felis catus DOCK1 VGNC VGNC:97403
Canis familiaris DOCK1 VGNC VGNC:40043