DOCK1 - dedicator of cytokinesis 1 Gene

Homo sapiens

Also known as ced5; DOCK180

Gene ID: 1793 | Gene type: protein coding

About DOCK1

Cytogenetic location: 10q26.2 Genomic coordinates (GRCh38): 10:126,905,428-127,452,516 (from NCBI)

This gene has 6 transcripts (splice variants), 226 orthologues and 10 paralogues. Ubiquitous expression in thyroid (RPKM 10.9), skin (RPKM 10.0) and 24 other tissues.

Summary

This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

DOCK1 Products(14)

mRNA	Protein	Name
NM_001290223.2	NP_001277152.2	dedicator of cytokinesis protein 1 isoform 1
NM_001377543.1	NP_001364472.1	dedicator of cytokinesis protein 1 isoform 3
NM_001377544.1	NP_001364473.1	dedicator of cytokinesis protein 1 isoform 4
NM_001377546.1	NP_001364475.1	dedicator of cytokinesis protein 1 isoform 5
NM_001377547.1	NP_001364476.1	dedicator of cytokinesis protein 1 isoform 6
NM_001377548.1	NP_001364477.1	dedicator of cytokinesis protein 1 isoform 7
NM_001377550.1	NP_001364479.1	dedicator of cytokinesis protein 1 isoform 8
NM_001377553.1	NP_001364482.1	dedicator of cytokinesis protein 1 isoform 9
NM_001377554.1	NP_001364483.1	dedicator of cytokinesis protein 1 isoform 10
NM_001377556.1	NP_001364485.1	dedicator of cytokinesis protein 1 isoform 11
NM_001377558.1	NP_001364487.1	dedicator of cytokinesis protein 1 isoform 12
NM_001377560.1	NP_001364489.1	dedicator of cytokinesis protein 1 isoform 13
NM_001377561.1	NP_001364490.1	dedicator of cytokinesis protein 1 isoform 14
NM_001380.5	NP_001371.2	dedicator of cytokinesis protein 1 isoform 2

DOCK1 Protein Structure

SH3_9

DOCK-C2

DHR-2

0
300
600
900
1200
1500
1865 a.a.

Protein Preferred Names

Protein Names

dedicator of cytokinesis protein 1

180 kDa protein downstream of CRK

Related Diseases

Diseases

Alias

Chromosome 10q26 Deletion Syndrome

Distal 10q Deletion Syndrome	Terminal Chromosome 10q26 Deletion Syndrome
Distal Monosomy 10q	Monosomy 10qter
Telomeric Deletion 10q	Distal Deletion 10q
10q26 Deletion Syndrome	10qter Deletion
Telomeric Deletion 10

Immunodeficiency 40

Dock2 Deficiency	IMD40
Immunodeficiency, Type 40

Spinocerebellar Ataxia, Autosomal Recessive 15

Autosomal Recessive Spinocerebellar Ataxia 15	SCAR15
Salih Ataxia	Autosomal Recessive Cerebellar Ataxia-Epilepsy-Intellectual Disability Syndrome Due To Rubcn Deficiency
Autosomal Recessive Spinocerebellar Ataxia Type 15	Spinocerebellar Ataxia, Autosomal Recessive, 15
Ataxia, Spinocerebellar, Autosomal Recessive, Type 15

Stereotypic Movement Disorder

Stereotypy Habit Disorder	Stereotyped Repetitive Movements
Stereotyped Disorder	Stereotypes Nos
Stereotype Habit Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136177	Tris(2,4-di-tert-butylphenyl)phosphate	Inhibitor	99.81%	Unkown
HY-124711	TBOPP	Inhibitor	99.96%	Unkown
HY-RS03921	DOCK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DOCK1	VGNC	VGNC:28154
Macaca mulatta	DOCK1	VGNC	VGNC:71965
Mus musculus	DOCK1	MGD	MGI:2429765
Rattus norvegicus	DOCK1	RGD	RGD:1566072
Felis catus	DOCK1	VGNC	VGNC:97403
Canis familiaris	DOCK1	VGNC	VGNC:40043

Name
Email *

	Sorry, but the email address you supplied was invalid.