DOK1 - docking protein 1 Gene

Homo sapiens

Also known as pp62; P62DOK

Gene ID: 1796 | Gene type: protein coding

About DOK1

Cytogenetic location: 2p13.1 Genomic coordinates (GRCh38): 2:74,549,105-74,557,551 (from NCBI)

This gene has 13 transcripts (splice variants), 196 orthologues and 7 paralogues. Ubiquitous expression in fat (RPKM 6.6), spleen (RPKM 6.2) and 25 other tissues.

Summary

The protein encoded by this gene is part of a signal transduction pathway downstream of Receptor Tyrosine Kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

DOK1 Products(6)

mRNA	Protein	Name
NM_001197260.2	NP_001184189.1	docking protein 1 isoform b
NM_001318866.2	NP_001305795.1	docking protein 1 isoform b
NM_001318867.2	NP_001305796.1	docking protein 1 isoform c
NM_001318868.2	NP_001305797.1	docking protein 1 isoform d
NM_001318869.2	NP_001305798.1	docking protein 1 isoform e
NM_001381.5	NP_001372.1	docking protein 1 isoform a

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16273093	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	23822091	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DOK1 Protein Structure

IRS

0
100
200
300
400
481 a.a.

Protein Preferred Names

Protein Names

docking protein 1

Downstream of tyrosine kinase 1

Related Diseases

Diseases

Alias

Myopia 28, Autosomal Recessive

MYP28

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia	Chronic Myelogenous Leukemia
CML	Chronic Granulocytic Leukemia
Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib	Chronic Myeloid Leukaemia
Chronic Granulocytic Leukaemia	Chronic Myelogenous Leukaemia
Myeloid Leukemia, Chronic	Leukemia, Chronic Myelogenous
Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic	Cml - Chronic Myelogenous Leukemia
Cgl	Chronic Myelocytic Leukemia
Leukemia, Chronic Myeloid, Atypical	ACML
Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative	Myeloid Leukemia Chronic
Leukemia, Myeloid, Chronic	Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative
Cml- [Chronic Myeloid Leukaemia]	Cgl - [Chronic Granulocytic Leukaemia]
Chronic Myelocytic Leukaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03933	DOK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DOK1	MGD	MGI:893587
Bos taurus	DOK1	VGNC	VGNC:28165
Canis familiaris	DOK1	VGNC	VGNC:40055
Rattus norvegicus	DOK1	RGD	RGD:1309499
Macaca mulatta	DOK1	VGNC	VGNC:71968
Felis catus	DOK1	VGNC	VGNC:61580
Macaca fascicularis	DOK1	NCBI	NCBI:102127645
Others	DOK1	NCBI

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