2. Gene
  3. DPEP1 - dipeptidase 1 Gene

DPEP1 - dipeptidase 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MDP; RDP; MBD1

Gene ID: 1800 | Gene type: protein coding

About DPEP1

Cytogenetic location: 16q24.3 Genomic coordinates (GRCh38): 16:89,613,308-89,641,540 (from NCBI)

This gene has 10 transcripts (splice variants), 200 orthologues and 2 paralogues. Biased expression in small intestine (RPKM 104.6), kidney (RPKM 102.2) and 3 other tissues.

Summary

The protein encoded by this gene is a kidney membrane Enzyme involved in the metabolism of glutathione and Other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. [provided by RefSeq, Dec 2020]

DPEP1 Products(8)

mRNA Protein Name
NM_001128141.3 NP_001121613.1 dipeptidase 1 isoform a precursor
NM_001389466.1 NP_001376395.1 dipeptidase 1 isoform a precursor
NM_001389467.1 NP_001376396.1 dipeptidase 1 isoform a precursor
NM_001389468.1 NP_001376397.1 dipeptidase 1 isoform a precursor
NM_001389469.1 NP_001376398.1 dipeptidase 1 isoform a precursor
NM_001389470.1 NP_001376399.1 dipeptidase 1 isoform b precursor
NM_001389471.1 NP_001376400.1 dipeptidase 1 isoform b precursor
NM_004413.4 NP_004404.1 dipeptidase 1 isoform a precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables beta-lactamase activity IDA
IDA: Inferred from direct assay
6334084 GOA
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
20435919 GOA
enables dipeptidase activity IDA
IDA: Inferred from direct assay
32325220 GOA
enables metallodipeptidase activity IDA
IDA: Inferred from direct assay
12144777 GOA
enables modified amino acid binding IDA
IDA: Inferred from direct assay
20031578 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
12144777 GOA
Biological Process GO Annotation Evidence Reference Source
involved in antibiotic metabolic process IDA
IDA: Inferred from direct assay
6334084 GOA
involved in cellular response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
20435919 GOA
involved in homocysteine metabolic process IDA
IDA: Inferred from direct assay
20031578 GOA
involved in leukotriene D4 catabolic process IDA
IDA: Inferred from direct assay
32325220 GOA
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
20435919 GOA
involved in negative regulation of cell migration IMP
IMP: Inferred from mutant phenotype
20824289 GOA
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
20435919 GOA
Cellular Component GO Annotation Evidence Reference Source
located in apical part of cell IDA
IDA: Inferred from direct assay
20824289 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
12144777 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DPEP1 Protein Structure

Peptidase_M19

Peptidase_M19: Membrane dipeptidase (Peptidase family M19) (26 - 351)

  • 0
  • 100
  • 200
  • 300
  • 411 a.a.
Protein Preferred Names Protein Names

dipeptidase 1

beta-lactamase

DPEP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
DPEP1 P16444 APPBP2 Homo sapiens Q92624
Y2H Prey Pooling
25416956
Intra
DPEP1 P16444 APPBP2 Homo sapiens Q92624
Validated Y2H
25416956
Intra
DPEP1 P16444 KIFBP Homo sapiens Q96EK5
Pull Down
16189514
Intra
DPEP1 P16444 KIFBP Homo sapiens Q96EK5
Y2H Pooling
16189514
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DPEP1 Proteins

Cat. No. Product Name Accession Purity
HY-P70003 DPEP1 Protein, Human (HEK293, His) P16444 (D17-S385) ≥95%

Related Diseases

Diseases Alias
Blau Syndrome

Arthrocutaneouveal Granulomatosis

Jabs Syndrome

BLAUS

Sarcoidosis, Early-Onset

Acug

Granulomatous Inflammatory Arthritis, Dermatitis, And Uveitis, Familial

Eos

Granulomatosis, Familial Juvenile Systemic

Granulomatosis, Familial, Blau Type

Familial Juvenile Systemic Granulomatosis

Early Onset Sarcoidosis

Synovitis Granulomatous With Uveitis And Cranial Neuropathies

Early-Onset Sarcoidosis

Familial Granulomatosis, Blau Type

Pediatric Granulomatous Arthritis

Familial Granulomatosis Blau Type

Familial Granulomatous Inflammatory Arthritis Dermatitis And Uveitis

Synovitis, Granulomatous, With Uveitis And Cranial Neuropathies
Carbapenem Allergy
Bacterial Infectious Disease

Bacterial Infections

Bacterial Infection Nos

Disease Caused By Bacteria

Bacterial Disease Or Disorder
Crohn'S Disease

Crohn Disease

Pediatric Crohn'S Disease

Regional Enteritis

Crohn'S Disease Of Large Bowel

Granulomatous Colitis

Enteritis, Granulomatous

Enteritis

Crohn'S Disease Of Colon

Colitis, Granulomatous

Crohn'S Enteritis

Enteritis, Regional

Ileitis

Adenoviral Enteritis

Acute Gastroenteropathy Due To Norwalk Agent

Viral Gastroenteritis Due To Norwalk Agent

Winter Vomiting

Epidemic Winter Vomiting Disease

Small Round Structured Virus Enteritis

Epidemic Vomiting Syndrome

Epidemic Vomiting

Epidemic Nausea

Epidemic Viral Gastroenteritis Due To Norwalk Virus

Noroviral Enteritis

Crohn Disease Nos

Crohns

Cd - [Crohn'S Disease]

Regional Enteritis Of Bowel

Crohn'S Regional Enteritis

Cobble-Stone Appearance Of Intestine

Intestinal Ulcer And Erosion Due To Crohn Disease

Granulomatous Enteritis
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03947 DPEP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DPEP1 VGNC VGNC:61593
Canis familiaris DPEP1 VGNC VGNC:49599
Macaca mulatta DPEP1 VGNC VGNC:71972
Mus musculus DPEP1 MGD MGI:94917
Bos taurus DPEP1 VGNC VGNC:49143
Rattus norvegicus DPEP1 RGD RGD:620324
Others DPEP1 NCBI