DRG2 - developmentally regulated GTP binding protein 2 Gene

Homo sapiens

Gene ID: 1819 | Gene type: protein coding

About DRG2

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:18,087,948-18,107,969 (from NCBI)

This gene has 21 transcripts (splice variants), 215 orthologues and 4 paralogues. Ubiquitous expression in ovary (RPKM 11.9), prostate (RPKM 10.9) and 25 other tissues.

Summary

This gene encodes a GTP-binding protein known to function in the regulation of cell growth and differentiation. Read-through transcripts containing this gene and a downstream gene have been identified, but they are not thought to encode a fusion protein. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jan 2012]

DRG2 Products(2)

mRNA	Protein	Name
NM_001330144.2	NP_001317073.1	developmentally-regulated GTP-binding protein 2 isoform 2
NM_001388.5	NP_001379.1	developmentally-regulated GTP-binding protein 2 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activity	IDA IDA: Inferred from direct assay	29915238	GOA
enables RNA binding	IDA IDA: Inferred from direct assay	29915238	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	29915238	GOA
located in nucleus	IDA IDA: Inferred from direct assay	29915238	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DRG2 Protein Structure

MMR_HSR1

TGS

0
100
200
300
364 a.a.

Protein Preferred Names

Protein Names

developmentally-regulated GTP-binding protein 2

TRAFAC GTPase DRG2

DRG2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DRG2	P55039	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	DRG2	P55039	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	DRG2	P55039	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	DRG2	P55039	TSSK3	Homo sapiens	Q96PN8	Validated Y2H	32296183
Intra	DRG2	P55039	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	DRG2	P55039	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	DRG2	P55039	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	DRG2	P55039	RWDD1	Homo sapiens	Q9H446	Anti Tag CoIP	33961781
Intra	DRG2	P55039	RWDD1	Homo sapiens	Q9H446	Validated Y2H	25416956
Intra	DRG2	P55039	RWDD1	Homo sapiens	Q9H446	Y2H Pooling	16189514
Intra	DRG2	P55039	RWDD1	Homo sapiens	Q9H446	Anti Tag CoIP	28514442
Intra	DRG2	P55039	RWDD1	Homo sapiens	Q9H446	Validated Y2H	32296183
Intra	DRG2	P55039	RWDD1	Homo sapiens	Q9H446	Y2H Array	32296183
Intra	DRG2	P55039	RWDD1	Homo sapiens	Q9H446	Y2H Prey Pooling	32296183
Intra	DRG2	P55039	NAB2	Homo sapiens	Q15742	Validated Y2H	32296183
Intra	DRG2	P55039	NAB2	Homo sapiens	Q15742	Y2H Array	32296183
Intra	DRG2	P55039	NAB2	Homo sapiens	Q15742	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Smith-Magenis Syndrome

SMS	Chromosome 17p11.2 Deletion Syndrome
17p11.2 Microdeletion Syndrome	17p11.2 Monosomy
Chromosome 17p Deletion Syndrome	Del(17)
P11.2	17p- Syndrome
Deletion 17p Syndrome	Partial Monosomy 17p

Volkmann Contracture

Ischemic Contracture

Volkmann'S Ischemic Contracture

Radial Neuropathy

Potocki-Lupski Syndrome

PTLS	Chromosome 17p11.2 Duplication Syndrome
17p11.2 Microduplication Syndrome	Duplication 17p11.2 Syndrome
Trisomy 17p11.2	Potocki-Lupski Syndrome (Dup(17)(P11.2p11.2))
17p11.2 Duplication Syndrome	Dup(17)(P11.2p11.2)
Pls	Chromosome 17, Trisomy 17p11 2

Craniometaphyseal Dysplasia, Autosomal Dominant

Craniometaphyseal Dysplasia	CMDD
Cmdj	Cmd
Autosomal Dominant Craniometaphyseal Dysplasia	Craniometaphyseal Dysplasia, Jackson Type
Craniometaphyseal Dysplasia Jackson Type	Autosomal Recessive Craniometaphyseal Dysplasia
Cmdr	Dysplasia, Craniometaphyseal, Autosomal Dominant
Craniometaphyseal Dysplasia, Autosomal Recessive Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04010	DRG2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DRG2	VGNC	VGNC:28209
Felis catus	DRG2	VGNC	VGNC:61631
Canis familiaris	DRG2	VGNC	VGNC:40098
Rattus norvegicus	DRG2	RGD	RGD:1562380
Mus musculus	DRG2	MGD	MGI:1342307
Macaca mulatta	DRG2	VGNC	VGNC:71993

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