NAB2 - NGFI-A binding protein 2 Gene

Homo sapiens

Also known as MADER

Gene ID: 4665 | Gene type: protein coding

About NAB2

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:57,089,114-57,095,476 (from NCBI)

This gene has 5 transcripts (splice variants), 200 orthologues, 1 paralogue and is associated with 51 phenotypes. Ubiquitous expression in endometrium (RPKM 17.8), ovary (RPKM 17.7) and 25 other tissues.

Summary

This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

NAB2 Products(2)

mRNA	Protein	Name
NM_001330305.2	NP_001317234.1	NGFI-A-binding protein 2 isoform 2
NM_005967.4	NP_005958.1	NGFI-A-binding protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within negative regulation of transcription by RNA polymerase III	IDA IDA: Inferred from direct assay	8668170	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NAB2 Protein Structure

NCD1

NCD2

0
100
200
300
400
525 a.a.

Protein Preferred Names

Protein Names

NGFI-A-binding protein 2

EGR1 binding protein 2

Related Diseases

Diseases

Alias

Solitary Fibrous Tumor/Hemangiopericytoma

Sft/Hpc

Meninges Hemangiopericytoma

Hemangiopericytoma Of Meninges

Meningeal Hemangiopericytoma

Thymus Sarcomatoid Carcinoma

Thymic Carcinosarcoma

Thymic Sarcomatoid Carcinoma

Benign Pleural Mesothelioma

Mesothelioma Of Pleura	Benign Neoplasm Of Mesothelial Tissue Of Pleura
Pleural Malignant Mesothelioma

Spindle Cell Lipoma

Potter'S Syndrome

Potter Sequence	Potter Syndrome
Oligohydramnios Sequence	Congenital Absence Of Kidneys Syndrome

Perivascular Tumor

Malignant Perivascular Cancer

Hemangiopericytoma, Malignant

Hemangiopericytoma	Haemangiopericytic Meningioma
Malignant Hemangiopericytoma	Solitary Fibrous Tumor

Secondary Hypertrophic Osteoarthropathy

Osteoarthropathy, Secondary Hypertrophic	Bamberger-Marie Disease
Hpoa - Hypertrophic Pulmonary Osteoarthropathy	Hypertrophic Pulmonary Osteoarthropathy
Marie Bamberger Disease

Fibrous Meningioma

Fibroblastic Meningioma

Benign Fibrous Mesothelioma

Fibrous Mesothelioma, Benign	Localized Benign Fibrous Mesothelioma
Solitary Fibrous Tumor, Pleural	Pleural Solitary Fibrous Tumor
Solitary Fibrous Tumor

Mediastinal Mesenchymal Tumor

Mediastinal Mesenchymal Tumour	Soft Tissue Tumor Of Mediastinum
Soft Tissue Tumour Of Mediastinum

Pericytoma With T(7;12)

Mesenchymal Cell Neoplasm

Benign Miscellaneous Mesenchymal Tumor	Mesenchymal Tumor
Mesenchymal Tumors

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Nasal Cavity Benign Neoplasm

Benign Nasal Cavity Neoplasm	Neoplasm Of Nasal Cavity
Tumor Of The Nasal Cavity	Cancer Of Nasal Cavity
Nostril Cancer	Primary Malignant Neoplasm Of Nasal Cavity
Primary Malignant Neoplasm Of Vestibule Of Nose

Vascular Cancer

Blood Vessel Tumors	Malignant Vascular Neoplasm
Renal Vein Leiomyosarcoma	Vascular Neoplasms
Blood Vessel Neoplasm	Blood Vessel Tumor
Blood Vessel Tumour Disorder	Haemangiomatous Tumour
Leiomyosarcoma Of The Renal Vein	Malignant Great Vessel Tumor
Malignant Tumor Of Pulmonary Artery	Malignant Tumor Of Pulmonary Vein
Malignant Vascular Tumor	Neoplasm Of Great Vessel
Pulmonary Artery Malignant Neoplasm	Pulmonary Vein Malignant Neoplasm
Vascular Tissue Neoplasm	Vascular Tumors
Blood Vessel Cancer	Neoplasms, Vascular Tissue
Malignant Neoplasm Of Great Vessels

Pseudosarcomatous Fibromatosis

Nodular Fasciitis	Pseudosarcomatous Fasciitis
Fasciitis - Nodular	Fasciitis Nodular

Myxofibrosarcoma

Fibromyxosarcoma	Fibromyxoid Sarcoma
Myxoid Malignant Fibrous Histiocytoma	Dermatofibrosarcoma Protuberans, Myxoid

Monophasic Synovial Sarcoma

Monophasic Sarcoma Of Synovium

Sarcomatoid Mesothelioma

Malignant Fibrous Mesothelioma

Spindled Mesothelioma

Dedifferentiated Liposarcoma

Ddls	Liposarcoma Dedifferentiated
Liposarcoma, Dedifferentiated

Spindle Cell Thymoma

Medullary Thymoma	Thymoma, Medullary
Thymoma, Type A

Chordoid Meningioma

Meningioma, Chordoid

Papillary Craniopharyngioma

Craniopharyngioma, Papillary	Papillary Rathke'S Pouch Tumor
Craniopharyngioma Papillary

Dermatofibrosarcoma Protuberans

DFSP	Dermatofibrosarcoma
Giant Cell Fibroblastoma	Metastatic Dermatofibrosarcoma Protuberans
Familial Dermatofibrosarcoma Protuberans	Darier-Ferrand Tumor
Darier-Hoffmann Tumor

Synovium Cancer

Malignant Tumor Of Synovium

Synovial Neoplasm

Lipomatosis, Multiple

Lipoma	Familial Multiple Lipomatosis
Lipomatosis, Familial Multiple	Benign Lipomatous Tumor
Lipomatous Neoplasm	Multiple Lipomatosis
Fml	Lipo
Benign Tumor Of Adipose Tissue	Lipomatous Tumor
Tumor Of Adipose Tissue	Neoplasms, Adipose Tissue
Lipomas

Well-Differentiated Liposarcoma

Atypical Lipomatous Tumor	Atypical Lipoma
Alt	Wdls
Liposarcoma, Well Differentiated	Pleomorphic Lipoma

Infantile Myofibromatosis

Lipofibromatosis

Myofibromatosis

Hypertrophic Neuropathy Of Dejerine-Sottas

Dejerine-Sottas Disease	Dejerine-Sottas Syndrome
Charcot-Marie-Tooth Disease Type 3	DSS
Hereditary Motor And Sensory Neuropathy Type Iii	Hmsn3
Dejerine-Sottas Neuropathy	Hmsn Iii
Charcot-Marie-Tooth Disease, Type 3	Cmt3
Dsn	Hmsn 3
Hereditary Motor And Sensory Neuropathy Type 3	Hereditary Motor And Sensory Neuropathy 3
Hypertrophic Neuropathy Of Infancy	Charcot-Marie-Tooth Disease Demyelinating Type 4f
Charcot-Marie-Tooth Disease Type 4f	Charcot-Marie-Tooth Neuropathy Type 4f
Cmt4f	Hereditary Motor And Sensory Neuropathy Iii
Charcot-Marie-Tooth Disease, Demyelinating, Type 4f

Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive

Charcot-Marie-Tooth Disease Type 4	Charcot-Marie-Tooth Disease Type 4e
Hereditary Motor And Sensory Neuropathy	Cmt4e
CHN1	Hypomyelinating Neuropathy, Congenital, 1
Charcot-Marie-Tooth Neuropathy Type 4e	Neuropathy, Congenital Hypomyelinating, 1
Ar-Cmt1	Autosomal Recessive Demyelinating Charcot-Marie-Tooth
Cmt4	Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive
Hypomyelination, Severe Congenital	Charcot-Marie-Tooth Disease, Type 4e
Charcot-Marie-Tooth Neuropathy, Type 4e	Autosomal Recessive Congenital Hypomyelinating Or Amyelinating Neuropathy
Autosomal Recessive Congenital Hypomyelinating Neuropathy	Congenital Amyelinating Neuropathy
Congenital Hypomyelinating Neuropathy Autosomal Recessive	Neuropathy, Congenital Hypomyelinating Or Amyelinating
Severe Congenital Hypomyelination	Hereditary Sensory Motor Neuropathy
Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive	Neuropathy, Hypomyelinating, Congenital, Type 1
Neuropathy, Motor And Sensory, Hereditary	Congenital Hypomyelinating Neuropathy
Hereditary Motor And Sensory Neuropathies	Hereditary Sensorimotor Neuropathy
Hmsn - [Hereditary Motor And Sensory Neuropathy]	Hsmn - [Hereditary Sensory And Motor Neuropathy]
Hereditary Motor And Sensory Neuropathy, Types I-Iv

Myxoid Liposarcoma

Myxoid/Round Cell Liposarcoma	Liposarcoma, Myxoid
Mrcls	Myxoliposarcoma
MXLIPO	Liposarcoma Myxoid
Liposarcoma

Sarcoma, Synovial

Synovial Sarcoma	Synovialosarcoma
Synovial Cell Sarcoma	Sarcoma Synovial

Inflammatory Myofibroblastic Tumor

Inflammatory Fibrosarcoma

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-110174	NAB2		99.69%	Unkown
HY-RS08997	NAB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NAB2	VGNC	VGNC:43601
Macaca mulatta	NAB2	VGNC	VGNC:75125
Bos taurus	NAB2	VGNC	VGNC:31858
Felis catus	NAB2	VGNC	VGNC:68409
Mus musculus	NAB2	MGD	MGI:107563
Rattus norvegicus	NAB2	RGD	RGD:1311712