IGBP1 - immunoglobulin binding protein 1 Gene

Homo sapiens

Also known as IBP1; MRXS28; alpha4; ALPHA-4

Gene ID: 3476 | Gene type: protein coding

About IGBP1

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:70,133,447-70,166,324 (from NCBI)

This gene has 2 transcripts (splice variants), 236 orthologues, 1 paralogue and is associated with 4 phenotypes. Ubiquitous expression in ovary (RPKM 49.2), thyroid (RPKM 31.5) and 25 other tissues.

Summary

The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways. [provided by RefSeq, Jul 2008]

IGBP1 Products(4)

mRNA	Protein	Name
NM_001370192.1	NP_001357121.1	immunoglobulin-binding protein 1 isoform 1
NM_001370193.1	NP_001357122.1	immunoglobulin-binding protein 1 isoform 1
NM_001370194.1	NP_001357123.1	immunoglobulin-binding protein 1 isoform 2
NM_001551.3	NP_001542.1	immunoglobulin-binding protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9647778	GOA
enables protein phosphatase regulator activity	IDA IDA: Inferred from direct assay	9647778	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	17438131	GOA
involved in negative regulation of stress-activated MAPK cascade	IMP IMP: Inferred from mutant phenotype	17438131	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17438131	GOA
involved in regulation of microtubule-based movement	IMP IMP: Inferred from mutant phenotype	18949047	GOA
involved in response to interleukin-1	IMP IMP: Inferred from mutant phenotype	17438131	GOA
involved in response to tumor necrosis factor	IMP IMP: Inferred from mutant phenotype	17438131	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IGBP1 Protein Structure

TAP42

0
100
200
300
339 a.a.

Protein Preferred Names

Protein Names

immunoglobulin-binding protein 1

B cell signal transduction molecule alpha 4

IGBP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	IGBP1	P78318	PPP2CB	Homo sapiens	P62714	Anti Tag CoIP	26496610
Intra	IGBP1	P78318	PPP4C	Homo sapiens	P60510	Anti Tag CoIP	18715871
Intra	IGBP1	P78318	PPP4C	Homo sapiens	P60510	Anti Tag CoIP	16769727
Intra	IGBP1	P78318	PPP4C	Homo sapiens	P60510	TAP	16085932
Intra	IGBP1	P78318	PPP4C	Homo sapiens	P60510	Anti Tag CoIP	26496610
Intra	IGBP1	P78318	TIPRL	Homo sapiens	O75663	Anti Bait CoIP	23892082
Intra	IGBP1	P78318	MID1	Homo sapiens	O15344	Anti Tag CoIP	26496610
Intra	IGBP1	P78318	HSPB1	Homo sapiens	P04792	Reverse RRS	25277244
Intra	IGBP1	P78318	PPP6C	Homo sapiens	O00743	Anti Tag CoIP	18186651
Intra	IGBP1	P78318	PPP6C	Homo sapiens	O00743	Y2H	9647778
Intra	IGBP1	P78318	PPP6C	Homo sapiens	O00743	TAP	16085932
Intra	IGBP1	P78318	PPP6C	Homo sapiens	O00743	Anti Tag CoIP	26496610
Intra	IGBP1	P78318	PPP6C	Homo sapiens	O00743	Pull Down	9647778
Intra	IGBP1	P78318	PPP2CA	Homo sapiens	P67775	Anti Tag CoIP	9647778
Intra	IGBP1	P78318	PPP2CA	Homo sapiens	P67775	Anti Tag CoIP	26496610
Intra	IGBP1	P78318	PPP2CA	Homo sapiens	P67775	TAP	16085932
Intra	IGBP1	P78318	PPP2CA	Homo sapiens	P67775	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Corpus Callosum, Agenesis Of, With Impaired Intellectual Development, Ocular Coloboma, And Micrognathia

MRXS28	Mental Retardation, X-Linked, Syndromic 28
Intellectual Development Disorder, X-Linked, Syndromic 28	Corpus Callosum, Agenesis Of, With Impaired Intellectual Development, Ocular Coloboma And Micrognathia
Intellectual Developmental Disorder, X-Linked, Syndromic 28	Agenesis Of The Corpus Callosum With Impaired Intellectual Development, Ocular Coloboma And Micrognathia

Corpus Callosum Agenesis-Intellectual Disability-Coloboma-Micrognathia Syndrome

Graham-Cox Syndrome	Corpus Callosum, Agenesis Of, With Mental Retardation, Ocular Coloboma And Micrognathia
Mental Retardation, X-Linked, Syndromic 28	Mrxs28
Agenesis Of The Corpus Callosum-Intellectual Disability-Coloboma-Micrognathia Syndrome	Agenesis, Corpus Callosum, With Mental Retardation, Ocular Coloboma And Micrognathia
Corpus Callosum, Agenesis Of, With Mental Retardation, Ocular Coloboma, And Micrognathia

Barbiturate Abuse

Progressive Multifocal Leukoencephalopathy

Pml	Leukoencephalopathy, Progressive Multifocal
Progressive Multifocal Leukoencephalitis	Leukoencephalopathy Progressive Multifocal
Pml - [Progressive Multifocal Leukoencephalopathy]

Autosomal Dominant Alport Syndrome

Alport Syndrome, Autosomal Dominant	Alport Syndrome Dominant Type
Renal Failure And Sensorineural Hearing Loss	Alport Syndrome, Dominant Type

Autosomal Recessive Alport Syndrome

Alport Syndrome, Recessive Type	Alport Syndrome, Autosomal Recessive
Alport Syndrome Autosomal Recessive	Alport Syndrome Recessive Type
Nephropathy And Deafness

Hemoglobin H Disease

HBH	Hemoglobin H Disease, Nondeletional
Hemoglobin H Disease, Deletional	Alpha-Thalassemia Intermedia
Haemoglobin H Disease	Alpha-Thalassemia, Hemoglobin H Type
Hemoglobin H Disease, Deletional And Nondeletional	Alpha Thalassemia, Haemoglobin H Type
Alpha Thalassemia, Hemoglobin H Type	Haemoglobin H Disease, Deletional
Hbh Disease	Alpha-Thalassemia Hemoglobin H Type
Hemoglobin H Disease Deletional	Hemoglobin H Disease Non-Deletional
Alpha-Thalassemia	Alpha - /- - Or Mutational Forms Of Alpha-Thalassaemia
Alpha Thalassaemia Intermedia

Hypoalphalipoproteinemia, Primary, 2

Apolipoprotein A-I Deficiency	Hypoalphalipoproteinemia, Primary, 2, Autosomal Recessive
Primary Hypoalphalipoproteinemia 2	High Density Lipoprotein Deficiency
Apoa-I Deficiency	Familial Apoa-I Deficiency
Familial Hypoalphalipoproteinemia	FHA2
Apolipoprotein A-I

Alport Syndrome

Hereditary Nephritis	Alport Syndrome, X-Linked
Hemorrhagic Hereditary Nephritis	Congenital Hereditary Hematuria
Hemorrhagic Familial Nephritis	Familial Nephritis
Thin Basement Membrane Disease	Thin Basement Membrane Nephropathy
Hematuria-Nephropathy-Deafness Syndrome	Hematuric Hereditary Nephritis
Hereditary Familial Congenital Hemorrhagic Nephritis	Hereditary Hematuria Syndrome
Hereditary Interstitial Pyelonephritis	Alport Deafness-Nephropathy
Alport Hearing Loss-Nephropathy	Alports Syndrome
Nephritis, Hereditary

Autosomal Dominant Nocturnal Frontal Lobe Epilepsy

Adnfle	Autosomal Dominant Sleep-Related Hypermotor Epilepsy
Enfl	Benign Familial Infantile Seizures 6
Benign Familial Infantile Seizures, 6	Nocturnal Frontal Lobe Epilepsy-4
Enfl1	Epilepsy, Nocturnal Frontal Lobe, 1
Epilepsy, Nocturnal Frontal Lobe, Type 1

Alpha-Thalassemia

Alpha Thalassemia	Alpha Thalassaemia
Alpha Plus Thalassemia	Thalassemia, Alpha-
Thalassemias, Alpha-	A-Thalassemia
Α-Thalassemia	A-THAL
Thalassemia	Alpha Thalassaemia Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06612	IGBP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	IGBP1	VGNC	VGNC:54166
Rattus norvegicus	IGBP1	RGD	RGD:62011
Mus musculus	IGBP1	MGD	MGI:1346500

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