E2F4 - E2F transcription factor 4 Gene

Homo sapiens

Also known as E2F-4

Gene ID: 1874 | Gene type: protein coding

About E2F4

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:67,192,155-67,198,918 (from NCBI)

This gene has 13 transcripts (splice variants), 253 orthologues and 7 paralogues. Ubiquitous expression in bone marrow (RPKM 45.6), placenta (RPKM 31.6) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic Amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human Cancer. [provided by RefSeq, Jul 2008]

E2F4 Products(1)

mRNA	Protein	Name
NM_001950.4	NP_001941.2	transcription factor E2F4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IMP IMP: Inferred from mutant phenotype	11418595	GOA
enables DNA-binding transcription activator activity	IDA IDA: Inferred from direct assay	17062573	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	11418595	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	11418595	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10488129	GOA
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	25100735	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11418595	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	16360038	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11418595	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	21454377	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17062573	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

E2F4 Protein Structure

E2F_TDP

0
100
200
300
413 a.a.

Protein Preferred Names

Protein Names

transcription factor E2F4

E2F transcription factor 4, p107/p130-binding

E2F4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	E2F4	Q16254	LIN9	Homo sapiens	Q5TKA1	Anti Bait CoIP	17159899
Intra	E2F4	Q16254	KAT5	Homo sapiens	Q92993	Validated Y2H	32296183
Intra	E2F4	Q16254	RB1	Homo sapiens	P06400	ITC	16360038
Intra	E2F4	Q16254	TFDP1	Homo sapiens	Q14186	ITC	16360038
Cross	E2F4	Q16254	E7	Human papillomavirus	P03129	Affinity Chrom	16061792
Intra	E2F4	Q16254	RBL2	Homo sapiens	Q08999	Anti Bait CoIP	22002537
Intra	E2F4	Q16254	RBL2	Homo sapiens	Q08999	Anti Bait CoIP	20133863

Cross: Cross-species interaction Intra: Intraspecies interaction

E2F4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82983	E2F4 Antibody (YA2728)	WB	Human

Related Diseases

Diseases

Alias

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Epilepsy, Idiopathic Generalized 3

EIG3	Idiopathic Generalized Epilepsy 3
Epilepsy, Idiopathic Generalized, Susceptibility To, 3	Epilepsy, Idiopathic Generalized Locus On Chromosome 9
Epilepsy, Idiopathic Generalized, Susceptibility To, Locus On Chromosome 9	Epilepsy, Idiopathic Generalized, Susceptibility To 3

Retinal Cancer

Malignant Neoplasm Of Retina	Retinal Neoplasms
Malignant Retinal Neoplasm	Malignant Tumor Of Retina
Neoplasm Of Retina	Retinal Tumor
Retinal Neoplasm	Cancer Of The Retina
Malignant Retinal Tumour	Malignant Tumour Of Retina
Primary Malignant Neoplasm Of Retina

Alstrom Syndrome

ALMS	Alström Syndrome
Alss	Alstrom-Hallgren Syndrome
Alstroem Syndrome

Familial Retinoblastoma

Hereditary Retinoblastoma

Retinoblastoma

Ocular Cancer

Eye Neoplasm	Eye Carcinoma
Eye Cancer	Eye Neoplasms
Malignant Eye Neoplasm	Neoplasm Of Eye
Neoplasm Of Eye Proper	Ocular Tumor
Carcinoma Of Eye	Ocular Carcinoma
Malignant Tumor Of Eye

Burkitt Lymphoma

Burkitt'S Lymphoma	BL
Burkitt Lymphoma, Somatic	Burkitt Lymphoma/Leukaemia
Burkitt'S Tumor	Burkitt'S Tumor Or Lymphoma
Malignant Lymphoma, Burkitt'S Type	Small Non-Cleaved Cell Lymphoma, Burkitt'S Type
Small Non-Cleaved Cell Lymphoma	Burkitt Tumor
Burkitts Lymphoma	Lymphoma, Small Noncleaved-Cell
Burkitt Tumour	Diffuse Small Noncleaved Malignant Burkitt Lymphoma
Malignant Burkitt Lymphoma	“Burkitt-Like” Lymphoma
Undifferentiated Burkitt Lymphoma	Small Noncleaved Cell Burkitt Lymphoma

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Retinal Disease

Retinal Diseases	Retinal Disorder
Retinal Disorders

Soft Palate Cancer

Malignant Tumor Of Soft Palate	Malignant Tumor Of The Soft Palate
Palate Cancer Soft Palate

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Eye Disease

Eye Diseases	Abnormality Of The Eye
Toxoplasma Oculopathy

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16667	HLM006474	Inhibitor	99.57%	Unkown
HY-RS04113	E2F4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	E2F4	MGD	MGI:103012
Rattus norvegicus	E2F4	RGD	RGD:2322129
Macaca mulatta	E2F4	VGNC	VGNC:72025
Felis catus	E2F4	VGNC	VGNC:61696
Bos taurus	E2F4	VGNC	VGNC:28288
Canis familiaris	E2F4	VGNC	VGNC:40166

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