2. Gene
  3. EBF1 - EBF transcription factor 1 Gene

EBF1 - EBF transcription factor 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as EBF; COE1; OLF1; O/E-1

Gene ID: 1879 | Gene type: protein coding

About EBF1

Cytogenetic location: 5q33.3 Genomic coordinates (GRCh38): 5:158,695,920-159,099,916 (from NCBI)

This gene has 11 transcripts (splice variants), 300 orthologues, 3 paralogues and is associated with 83 phenotypes. Broad expression in fat (RPKM 3.2), placenta (RPKM 0.8) and 17 other tissues.

Summary

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of transcription, DNA-templated. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]

EBF1 Products(15)

mRNA Protein Name
NM_001290360.3 NP_001277289.1 transcription factor COE1 isoform 1
NM_001324101.2 NP_001311030.1 transcription factor COE1 isoform 4
NM_001324103.2 NP_001311032.1 transcription factor COE1 isoform 5
NM_001324106.2 NP_001311035.1 transcription factor COE1 isoform 6
NM_001324107.2 NP_001311036.1 transcription factor COE1 isoform 7
NM_001324108.2 NP_001311037.1 transcription factor COE1 isoform 8
NM_001324109.2 NP_001311038.1 transcription factor COE1 isoform 9
NM_001324111.2 NP_001311040.1 transcription factor COE1 isoform 10
NM_001364155.2 NP_001351084.1 transcription factor COE1 isoform 11
NM_001364156.2 NP_001351085.1 transcription factor COE1 isoform 13
NM_001364157.2 NP_001351086.1 transcription factor COE1 isoform 14
NM_001364158.2 NP_001351087.1 transcription factor COE1 isoform 15
NM_001364159.2 NP_001351088.1 transcription factor COE1 isoform 16
NM_024007.5 NP_076870.1 transcription factor COE1 isoform 2
NM_182708.3 NP_874367.1 transcription factor COE1 isoform 3
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EBF1 Protein Structure

TIG

TIG: IPT/TIG domain (262 - 344)

  • 0
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  • 400
  • 500
  • 591 a.a.
Protein Preferred Names Protein Names

transcription factor COE1

Collier, Olf and EBF transcription factor 1

EBF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
EBF1 Q9UH73 HOMEZ Homo sapiens Q8IX15-3
Validated Y2H
25416956
Intra
EBF1 Q9UH73 HOMEZ Homo sapiens Q8IX15-3
Y2H Prey Pooling
25416956
Intra
EBF1 Q9UH73 HOMEZ Homo sapiens Q8IX15-3
Y2H Array
25416956
Intra
EBF1 Q9UH73 ATPAF2 Homo sapiens Q8N5M1
Y2H Array
25416956
Intra
EBF1 Q9UH73 ATPAF2 Homo sapiens Q8N5M1
MAPPIT
32296183
Intra
EBF1 Q9UH73 ATPAF2 Homo sapiens Q8N5M1
Y2H Array
32296183
Intra
EBF1 Q9UH73 ATPAF2 Homo sapiens Q8N5M1
Y2H Prey Pooling
32296183
Intra
EBF1 Q9UH73 POU6F2 Homo sapiens P78424
Y2H Array
32296183
Intra
EBF1 Q9UH73 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
Intra
EBF1 Q9UH73 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
EBF1 Q9UH73 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
EBF1 Q9UH73 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

EBF1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82193 EBF1 Antibody (YA1938) WB Human, Mouse

Related Diseases

Diseases Alias
Plasmacytoma

Solitary Plasmacytoma

Solitary Myeloma

Myeloma - Solitary

Myeloma, Solitary

Plasmacytoma - Category

Solitary Osseous Plasmacytoma

Solitary Plasmacytoma Without Mention Of Remission

Localised Malignant Plasma Cell Tumour Nos

Plasmacytoma Nos
Breast Abscess

Abscess Of Breast
B-Lymphoblastic Leukemia/Lymphoma With Bcr-Abl1

B-All With Bcr-Abl1

B-Lymphoblastic Leukemia/Lymphoma With T(9

22)(Q34.1

Q11.2)

Bcr-Abl1

B Lymphoblastic Leukemia/Lymphoma With T(9

22)(Q34.1

Q11.2)

Bcr-Abl1
Postpartum Depression

Maternity Blues

Postnatal Depression

Depression, Postpartum

Post-Partum Depression

Depression Postpartum
B-Lymphoblastic Leukemia/Lymphoma With Iamp21

B-All With Iamp21

Intrachromosomal Amplification Of Chromosome 21
Endogenous Depression

Clinical Depression

Unipolar Depression

Depressive Disorder
Tetanus Neonatorum

Neonatal Tetanus

NNT

Trismus Neonatorum

Newborn Trismus
Prion Disease

Spongiform Encephalopathy

Transmissible Spongiform Encephalopathies

Prion Diseases

Prion Disease Pathway

Transmissible Spongiform Encephalopathy

Prion Induced Disorder

Prion Protein Disease

Inherited Human Transmissible Spongiform Encephalopathies

Prion Protein Diseases

Prion-Associated Disorders

Prion-Induced Disorders

Transmissible Dementias

Tses

Human Prion Disease

Tse

Encephalopathy, Transmissible Spongiform

Prion Disease, Susceptibility To

Spongiform Encephalopathies

Human Transmissible Spongiform Encephalopathies, Inherited
B-Lymphoblastic Leukemia/Lymphoma

B Lymphoblastic Leukemia/Lymphoma

B-All

Precursor B Lymphoblastic Lymphoma/Leukemia

C-All

Lymphoblastic Lymphoma, Nos

Common Precursor B All

Lymphoblastic B-Cell Lymphoma

Pro-B All

B-Precursor Lymphoma

Lbl - [Lymphoblastic Lymphoma]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04124 EBF1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus EBF1 VGNC VGNC:50162
Macaca mulatta EBF1 VGNC VGNC:72030
Mus musculus EBF1 MGD MGI:95275
Rattus norvegicus EBF1 RGD RGD:620953
Felis catus EBF1 VGNC VGNC:61703
Canis familiaris EBF1 VGNC VGNC:40175
Others EBF1 NCBI