Plk1 - polo like kinase 1 Gene

Mus musculus

Also known as Plk; STPK13

Gene ID: 18817 | Gene type: protein coding

About Plk1

Chromosome 7: 121,758,662-121,769,096 forward strand.GRCm39:CM001000.3

This gene has 3 transcripts (splice variants), 186 orthologues, 4 paralogues and is associated with 16 phenotypes. Broad expression in liver E14.5 (RPKM 39.9), liver E14 (RPKM 38.7) and 17 other tissues.

Summary

The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and may play a role in DNA replication during S phase. This gene is expressed in all embryonic tissues, but restricted to thymus and ovaries in adult tissues. Homozygous knockout mice were embryonic lethal, suggesting that this gene is important for early embryonic development. This gene is thought to be a potential oncogene because it is overexpressed in a variety of tumors and tumor cell lines. Depletion of this protein in Cancer cells has been shown to inhibit cell proliferation and suppress oncogenic transformation; hence, it is a target for Cancer therapy. [provided by RefSeq, Sep 2015]

Plk1 Products(1)

mRNA	Protein	Name
NM_011121.4	NP_035251.3	serine/threonine-protein kinase PLK1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22405274	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	21637952	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	22405274	MGI
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	27979967	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within female meiosis chromosome segregation	IMP IMP: Inferred from mutant phenotype	25533956	MGI
acts upstream of or within homologous chromosome segregation	IMP IMP: Inferred from mutant phenotype	25533956	MGI
acts upstream of or within peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	27979967	MGI
acts upstream of or within peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	27979967	MGI
acts upstream of or within protein localization to organelle	IDA IDA: Inferred from direct assay	27979967	MGI
acts upstream of or within protein phosphorylation	IMP IMP: Inferred from mutant phenotype	22854038	MGI
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	21637952	MGI
acts upstream of or within regulation of protein binding	IMP IMP: Inferred from mutant phenotype	27979967	MGI
acts upstream of or within synaptonemal complex disassembly	IMP IMP: Inferred from mutant phenotype	22854038	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in centriolar satellite	IDA IDA: Inferred from direct assay	27979967	MGI
located in centriole	IDA IDA: Inferred from direct assay	27979967	MGI
located in chromatin	IDA IDA: Inferred from direct assay	22854038	MGI
located in chromosome, centromeric region	IDA IDA: Inferred from direct assay	26919979	MGI
located in condensed chromosome, centromeric region	IDA IDA: Inferred from direct assay	22854038	MGI
located in kinetochore	IDA IDA: Inferred from direct assay	25533956	MGI
located in mitotic spindle pole	IDA IDA: Inferred from direct assay	26919979	MGI
located in synaptonemal complex	IDA IDA: Inferred from direct assay	22854038	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Plk1 Protein Structure

STKc_PLK1

POLO_box_1

POLO_box_2

0
100
200
300
400
500
603 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase PLK1

PLK-1

serine/threonine-protein kinase 13

Recombinant Plk1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73706	PLK1 Protein, Mouse (sf9, His)	Q07832 (M1-S603)	≥95%

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12137	Volasertib	Inhibitor	99.41%	Yes
HY-12137A	Volasertib trihydrochloride	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12037A	Rigosertib	Inhibitor	99.01%	Phase 3
HY-12037	Rigosertib sodium	Inhibitor	99.57%	Phase 3
HY-50698	BI 2536	Inhibitor	99.95%	Phase 2
HY-15828	Onvansertib	Inhibitor	99.55%	Phase 2
HY-147298	Plogosertib	Inhibitor	99.95%	Phase 2
HY-50877	GSK461364	Inhibitor	99.82%	Phase 1
HY-15160	TAK-960	Inhibitor	99.75%	Phase 1
HY-12045	HMN-214	Inhibitor	99.16%	Phase 1
HY-15160B	TAK-960 dihydrochloride	Inhibitor	99.19%	Phase 1
HY-15160A	TAK-960 hydrochloride	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (22)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100789	ON1231320	Inhibitor	99.24%	Unkown
HY-11003	GW843682X	Inhibitor	99.89%	Unkown
HY-15161	Ro3280	Inhibitor	98.87%	Unkown
HY-18009	(Z)-LFM-A13	Inhibitor	99.80%	Unkown
HY-15155	MLN0905	Inhibitor	99.94%	Unkown
HY-108597	TC-S 7005	Inhibitor	99.68%	Unkown
HY-12134	Poloxin	Inhibitor	98.01%	Unkown
HY-15158	SBE13 Hydrochloride	Inhibitor	99.66%	Unkown
HY-15159	Cyclapolin 9	Inhibitor	99.16%	Unkown
HY-N8692	Dihydrobaicalein	Inhibitor	99.94%	Unkown
HY-158031	PLK1/BRD4-IN-5	Inhibitor	99.55%	Unkown
HY-160558	PLK1/BRD4-IN-3	Inhibitor	99.66%	Unkown
HY-77195	Poloxime	Inhibitor	≥95.0%	Unkown
HY-110002	LFM-A13	Inhibitor	99.65%	Unkown
HY-15158A	SBE13	Inhibitor	/	Unkown
HY-143471	WNY0824	Inhibitor	/	Unkown
HY-161521	PLK1-IN-10	Inhibitor	/	Unkown
HY-148974	PLK1-IN-5	Inhibitor	/	Unkown
HY-115589	YLT-11	Inhibitor	/	Unkown
HY-18651	(E/Z)-Rigosertib sodium		/	Unkown
HY-149100	PLK1-IN-6	Inhibitor	/	Unkown
HY-112395	BTO-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Plk1	NCBI	NCBI:5347

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