Pml - promyelocytic leukemia Gene

Mus musculus

Also known as Trim19; 1200009E24Rik

Gene ID: 18854 | Gene type: protein coding

About Pml

Summary

Enables SMAD binding activity. Involved in several processes, including defense response to Other organism; regulation of gene expression; and signal transduction by p53 class mediator. Acts upstream of or within several processes, including apoptotic signaling pathway; positive regulation of macromolecule metabolic process; and transmembrane receptor protein serine/threonine kinase signaling pathway. Located in PML body; cytosol; and nuclear matrix. Is extrinsic component of endoplasmic reticulum membrane. Colocalizes with heterochromatin. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia and skin Cancer. Orthologous to human PML (PML nuclear body scaffold). [provided by Alliance of Genome Resources, Apr 2022]

Pml Products(3)

mRNA	Protein	Name
NM_001311088.1	NP_001298017.1	protein PML isoform 3
NM_008884.5	NP_032910.3	protein PML isoform 1
NM_178087.4	NP_835188.2	protein PML isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SMAD binding	IDA IDA: Inferred from direct assay	15356634	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12529400	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	IMP IMP: Inferred from mutant phenotype	15626733	MGI
acts upstream of or within PML body organization	IDA IDA: Inferred from direct assay	12529400	MGI
acts upstream of or within SMAD protein signal transduction	IMP IMP: Inferred from mutant phenotype	15356634	MGI
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	9806545	MGI
acts upstream of or within branching involved in mammary gland duct morphogenesis	IMP IMP: Inferred from mutant phenotype	19261859	MGI
acts upstream of or within cell fate commitment	IMP IMP: Inferred from mutant phenotype	19261859	MGI
acts upstream of or within cellular response to interleukin-4	IDA IDA: Inferred from direct assay	9798653	MGI
acts upstream of or within cellular response to leukemia inhibitory factor	IEP IEP: Inferred from expression pattern	20439489	MGI
involved in circadian regulation of gene expression	IDA IDA: Inferred from direct assay	22274616	MGI
involved in endoplasmic reticulum calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	21030605	MGI
involved in entrainment of circadian clock by photoperiod	IDA IDA: Inferred from direct assay	22274616	MGI
acts upstream of or within extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	9806545	MGI
involved in fibroblast migration	IMP IMP: Inferred from mutant phenotype	23555679	MGI
involved in innate immune response	IDA IDA: Inferred from direct assay	18248090	MGI
acts upstream of or within intrinsic apoptotic signaling pathway by p53 class mediator	IMP IMP: Inferred from mutant phenotype	14992722	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage	IMP IMP: Inferred from mutant phenotype	9806545	MGI
involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP IMP: Inferred from mutant phenotype	15626733	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	21030605	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to oxidative stress	IMP IMP: Inferred from mutant phenotype	21030605	MGI
acts upstream of or within myeloid cell differentiation	IMP IMP: Inferred from mutant phenotype	9488655	MGI
acts upstream of or within negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	16915281	MGI
acts upstream of or within negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	9488655	MGI
involved in negative regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	24407287	MGI
involved in negative regulation of interleukin-1 production	IMP IMP: Inferred from mutant phenotype	24407287	MGI
involved in oncogene-induced cell senescence	IMP IMP: Inferred from mutant phenotype	10910364	MGI
acts upstream of or within positive regulation of apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	10684855	MGI
acts upstream of or within positive regulation of apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	10684855	MGI
involved in positive regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	23555679	MGI
involved in positive regulation of peptidyl-lysine acetylation	IMP IMP: Inferred from mutant phenotype	10910364	MGI
involved in positive regulation of signal transduction by p53 class mediator	IMP IMP: Inferred from mutant phenotype	10910364	MGI
acts upstream of or within protein import into nucleus	IMP IMP: Inferred from mutant phenotype	15356634	MGI
acts upstream of or within protein-containing complex localization	IMP IMP: Inferred from mutant phenotype	15356634	MGI
involved in regulation of calcium ion transport into cytosol	IMP IMP: Inferred from mutant phenotype	21030605	MGI
involved in regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	23555679	MGI
involved in regulation of circadian rhythm	IDA IDA: Inferred from direct assay	22274616	MGI
acts upstream of or within response to UV	IMP IMP: Inferred from mutant phenotype	15626733	MGI
acts upstream of or within response to gamma radiation	IMP IMP: Inferred from mutant phenotype	9806545	MGI
acts upstream of or within response to hypoxia	IMP IMP: Inferred from mutant phenotype	16915281	MGI
acts upstream of or within retinoic acid receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9488655	MGI
involved in suppression of viral release by host	IDA IDA: Inferred from direct assay	18248090	MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15356634	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in PML body	IDA IDA: Inferred from direct assay	16461359	MGI
located in PML body	IMP IMP: Inferred from mutant phenotype	10779416	MGI
located in cytosol	IDA IDA: Inferred from direct assay	21030605	MGI
located in nuclear matrix	IDA IDA: Inferred from direct assay	15252119	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10716735	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein PML

probable transcription factor PML

Pml Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Pml	Q8BSJ6	Nr2c1	Mus musculus	Q505F1	Anti Bait CoIP	18682553

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N10633	LSTc		≥98.0%	Unkown
HY-127130	Spicamycin		/	Unkown
HY-RS10765	PML Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pml	NCBI	NCBI:5371

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