PML - PML nuclear body scaffold Gene

Homo sapiens

Also known as MYL; RNF71; PP8675; TRIM19

Gene ID: 5371 | Gene type: protein coding

About PML

Cytogenetic location: 15q24.1 Genomic coordinates (GRCh38): 15:73,994,716-74,047,827 (from NCBI)

This gene has 22 transcripts (splice variants), 157 orthologues, 80 paralogues and is associated with 76 phenotypes. Ubiquitous expression in fat (RPKM 11.8), spleen (RPKM 8.1) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

PML Products(9)

mRNA	Protein	Name
NM_002675.4	NP_002666.1	protein PML isoform 6
NM_033238.3	NP_150241.2	protein PML isoform 1
NM_033239.3	NP_150242.1	protein PML isoform 9
NM_033240.3	NP_150243.2	protein PML isoform 2
NM_033244.4	NP_150247.2	protein PML isoform 5
NM_033246.3	NP_150249.1	protein PML isoform 7
NM_033247.3	NP_150250.2	protein PML isoform 8
NM_033249.3	NP_150252.1	protein PML isoform 10
NM_033250.3	NP_150253.2	protein PML isoform 11

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SUMO binding	IPI IPI: Inferred from physical interaction	17081985	GOA
enables SUMO transferase activity	EXP EXP: Inferred from Experiment	12393906	GOA
enables cobalt ion binding	IDA IDA: Inferred from direct assay	7729428	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	20719947	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9294197	GOA
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	7935403	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	9230084	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	11080164	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	12915590	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	7729428	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in PML body organization	IDA IDA: Inferred from direct assay	8643677	GOA
involved in PML body organization	IMP IMP: Inferred from mutant phenotype	17081985	GOA
involved in apoptotic process	IDA IDA: Inferred from direct assay	9583681	GOA
involved in cellular senescence	IDA IDA: Inferred from direct assay	22002537	GOA
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	11259576	GOA
involved in innate immune response	IDA IDA: Inferred from direct assay	18248090	GOA
involved in intrinsic apoptotic signaling pathway in response to DNA damage	IDA IDA: Inferred from direct assay	12402044	GOA
acts upstream of or within maintenance of protein location in nucleus	IDA IDA: Inferred from direct assay	17332504	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	7935403	GOA
involved in negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	16915281	GOA
involved in negative regulation of cell growth	IDA IDA: Inferred from direct assay	7935403	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	12006491	GOA
involved in negative regulation of mitotic cell cycle	IDA IDA: Inferred from direct assay	9395203	GOA
involved in negative regulation of telomere maintenance via telomerase	IMP IMP: Inferred from mutant phenotype	19567472	GOA
involved in negative regulation of translation in response to oxidative stress	IDA IDA: Inferred from direct assay	16915281	GOA
involved in negative regulation of ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	15195100	GOA
involved in positive regulation of apoptotic process involved in mammary gland involution	IDA IDA: Inferred from direct assay	11080164	GOA
involved in positive regulation of defense response to virus by host	IMP IMP: Inferred from mutant phenotype	16873256	GOA
involved in positive regulation of extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	21803845	GOA
involved in positive regulation of protein localization to chromosome, telomeric region	IDA IDA: Inferred from direct assay	22641345	GOA
involved in positive regulation of telomere maintenance	IMP IMP: Inferred from mutant phenotype	22641345	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	22406621	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	12773567	GOA
involved in protein targeting	IDA IDA: Inferred from direct assay	11080164	GOA
involved in protein targeting	IMP IMP: Inferred from mutant phenotype	15195100	GOA
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	12915590	GOA
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	23007646	GOA
involved in regulation of cell cycle	IDA IDA: Inferred from direct assay	9583681	GOA
involved in regulation of double-strand break repair	IMP IMP: Inferred from mutant phenotype	21639834	GOA
involved in response to cytokine	IDA IDA: Inferred from direct assay	9412458	GOA
involved in response to hypoxia	IDA IDA: Inferred from direct assay	16915281	GOA
involved in suppression of viral release by host	IDA IDA: Inferred from direct assay	18248090	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in PML body	IDA IDA: Inferred from direct assay	9412458	GOA
located in chromosome, telomeric region	IDA IDA: Inferred from direct assay	26119943	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	9885291	GOA
located in nuclear matrix	IDA IDA: Inferred from direct assay	11080164	GOA
located in nuclear membrane	IDA IDA: Inferred from direct assay	16778193	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	15195100	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	12915590	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9294197	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PML Protein Structure

zf-B_box

DUF3583

0
200
400
600
800
882 a.a.

Protein Preferred Names

Protein Names

protein PML

E3 SUMO-protein ligase PML

PML Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PML	P29590	PER2	Homo sapiens	O15055	Anti Bait CoIP	22274616
Intra	PML	P29590	PER2	Homo sapiens	O15055	IF	22274616
Intra	PML	P29590	MAPK7	Homo sapiens	Q13164	Protein Kinase Assay	20832753
Intra	PML	P29590	MAPK7	Homo sapiens	Q13164	Anti Bait CoIP	20832753
Intra	PML	P29590	TBX2	Homo sapiens	Q13207	Anti Bait CoIP	22002537
Intra	PML	P29590	TET2	Homo sapiens	Q6N021	Anti Bait CoIP	29735542
Intra	PML	P29590	PSMA3	Homo sapiens	P25788	Anti Tag CoIP	21988832
Intra	PML	P29590	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	PML	P29590	TP53	Homo sapiens	P04637	PLA	25241761
Intra	PML	P29590	TP53	Homo sapiens	P04637	Confocal	21057547
Intra	PML	P29590	TP53	Homo sapiens	P04637	Anti Bait CoIP	12915590
Intra	PML	P29590	MDM2	Homo sapiens	Q00987	Imaging	12915590
Intra	PML	P29590	MDM2	Homo sapiens	Q00987	Anti Bait CoIP	12915590
Intra	PML	P29590	FAS	Homo sapiens	P25445	Anti Bait CoIP	21803845
Intra	PML	P29590	ZBTB16	Homo sapiens	Q05516	Y2H	9294197
Intra	PML	P29590	ZBTB16	Homo sapiens	Q05516	Imaging	9294197
Intra	PML	P29590	TGIF1	Homo sapiens	Q15583	IF	18511908
Intra	PML	P29590	KLHL20	Homo sapiens	Q9Y2M5	Confocal	21840486
Intra	PML	P29590	KLHL20	Homo sapiens	Q9Y2M5	Competition Binding	20389280
Intra	PML	P29590	KLHL20	Homo sapiens	Q9Y2M5	Anti Tag CoIP	21840486
Intra	PML	P29590	KLHL20	Homo sapiens	Q9Y2M5	Anti Bait CoIP	21840486
Intra	PML	P29590	DAXX	Homo sapiens	Q9UER7	Anti Bait CoIP	21840486
Intra	PML	P29590	SUMO1	Homo sapiens	P63165	Anti Tag CoIP	17036045
Intra	PML	P29590	SUMO1	Homo sapiens	P63165	Anti Bait CoIP	21057547
Cross	PML	P29590	p03243-1	Human adenovirus C	P03243-1	Anti Bait CoIP	20639899
Cross	PML	P29590	p03243-1	Human adenovirus C	P03243-1	Confocal	20639899
Cross	PML	P29590	P27958-PRO_0000037566	Hepatitis C virus	P27958-PRO_0000037566	Anti Bait CoIP	16322229
Cross	PML	P29590	P27958-PRO_0000037566	Hepatitis C virus	P27958-PRO_0000037566	IF	16322229
Cross	PML	P29590	gag-pro-pol	Moloney murine leukemia virus	Q8UN00	Pull Down	22685230
Cross	PML	P29590	gag-pro-pol	Moloney murine leukemia virus	Q8UN00	Confocal	22685230
Cross	PML	P29590	gag-pro-pol	Moloney murine leukemia virus	Q8UN00	Anti Tag CoIP	22685230

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

Rabies

Lyssa	Hydrophobia
St Hubert Disease

Leukemia

Leukemias	Leukaemia, Unspecified, Without Mention Of Remission
Aleukemic Leukaemia	Chronic Leukaemia
Subacute Leukaemia	Leukaemia Disorder
Leukaemia Nos

Human Cytomegalovirus Infection

Cytomegalovirus Infection

Cytomegalovirus Infections

Herpes Simplex

Herpes Simplex Infections	Herpesvirus Hominis Disease
Herpes Simplex Disease	Herpesviral Infection Due To Herpes Simplex
Infections Due To Simplex Virus	Herpes Nos

Bloom Syndrome

BLM	Bs
Bls	Bloom-Torre-Machacek Syndrome
Microcephaly, Growth Restriction, And Increased Sister Chromatid Exchange 1	Mgrisce1
Congenital Telangiectatic Erythema	Congenital Telangiectatic Erythema Syndrome
Growth Deficiency, Sun-Sensitive, Telangiectatic, Hypo And Hyperpigmented Skin, Predisposition To Malignancy And Chromosomal Instability	Bloom'S Syndrome
Bsyn

Influenza

Flu	Influenza With Non-Respiratory Manifestation
Influenza With Other Manifestations	Influenza, Human
Influenza, Susceptibility To	Seasonal Influenza, Virus Identified

Dentatorubral-Pallidoluysian Atrophy

DRPLA	Naito-Oyanagi Disease
Haw River Syndrome	Myoclonic Epilepsy With Choreoathetosis
Nod	Ataxia, Chorea, Seizures, And Dementia
Dentatorubropallidoluysian Atrophy	Hrs
Naito Oyanagi Disease	Dentatorubral Pallidoluysian Atrophy
Dentatorubro-Pallidoluysian Atrophy	Myoclonic Epilepsies, Progressive
Atrophy, Pallidoluysian, Dentatorubral

Primary Biliary Cholangitis

Primary Biliary Cirrhosis	Biliary Liver Cirrhosis
Chronic Nonsuppurative Destructive Cholangitis	Familial Primary Biliary Cirrhosis
Pbc	Hanot Syndrome
Cholestatic Cirrhosis	Biliary Cirrhosis Primary
Liver Cirrhosis, Biliary	Hanot'S Cirrhosis
Biliary Cirrhosis	Pericholangiolic Biliary Cirrhosis
Tannhauser-Magendantz Syndrome	Hanot-Rossle Syndrome
Hypertrophic Cirrhosis	Todd Cirrhosis
Hanot Cirrhosis	Charcot Cirrhosis
Mahon-Tannhauser Syndrome	Toxic Cirrhosis
Hypertrophic Biliary Cirrhosis	Monolobular Cirrhosis
Unilobar Cirrhosis	Xanthomatous Biliary Cirrhosis

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia	Chronic Myelogenous Leukemia
CML	Chronic Granulocytic Leukemia
Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib	Chronic Myeloid Leukaemia
Chronic Granulocytic Leukaemia	Chronic Myelogenous Leukaemia
Myeloid Leukemia, Chronic	Leukemia, Chronic Myelogenous
Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic	Cml - Chronic Myelogenous Leukemia
Cgl	Chronic Myelocytic Leukemia
Leukemia, Chronic Myeloid, Atypical	ACML
Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative	Myeloid Leukemia Chronic
Leukemia, Myeloid, Chronic	Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative
Cml- [Chronic Myeloid Leukaemia]	Cgl - [Chronic Granulocytic Leukaemia]
Chronic Myelocytic Leukaemia

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Alpha-Thalassemia

Alpha Thalassemia	Alpha Thalassaemia
Alpha Plus Thalassemia	Thalassemia, Alpha-
Thalassemias, Alpha-	A-Thalassemia
Α-Thalassemia	A-THAL
Thalassemia	Alpha Thalassaemia Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N10633	LSTc		≥98.0%	Unkown
HY-127130	Spicamycin		/	Unkown
HY-RS10765	PML Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PML	MGD	MGI:104662
Macaca mulatta	PML	VGNC	VGNC:99295
Bos taurus	PML	VGNC	VGNC:99292
Felis catus	PML	VGNC	VGNC:99293
Canis familiaris	PML	VGNC	VGNC:99291
Rattus norvegicus	PML	RGD	RGD:1562602
Others	PML	NCBI

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