Nr2c1 - nuclear receptor subfamily 2, group C, member 1 Gene

Mus musculus

Also known as TR2; 80.3; Eenr; Tr2-11; 4831444H07Rik

Gene ID: 22025 | Gene type: protein coding

About Nr2c1

Summary

Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; histone deacetylase binding activity; and protein homodimerization activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of retinoic acid receptor signaling pathway. Located in PML body. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; jaw; and sensory organ. Orthologous to human NR2C1 (nuclear receptor subfamily 2 group C member 1). [provided by Alliance of Genome Resources, Apr 2022]

Nr2c1 Products(1)

mRNA	Protein	Name
NM_011629.3	NP_035759.3	nuclear receptor subfamily 2 group C member 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	9071982	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	9369481	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9369481	MGI
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	11463856	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9774688	MGI
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	9369481	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	8858600	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8858600	MGI
involved in positive regulation of retinoic acid receptor signaling pathway	IDA IDA: Inferred from direct assay	16130175	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in PML body	IDA IDA: Inferred from direct assay	18682553	MGI
located in nucleus	IDA IDA: Inferred from direct assay	9795341	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nuclear receptor subfamily 2 group C member 1

80-3 cNDA	early embryonic nuclear receptor
mTR2	nuclear receptor subfamily 2, group H, member 1
orphan nuclear receptor TR2	orphan receptor, TR2-11
testicular receptor 2

Nr2c1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Nr2c1	Q505F1	Pml	Mus musculus	Q8BSJ6	Anti Tag CoIP	18682553
Intra	Nr2c1	Q505F1	Pml	Mus musculus	Q8BSJ6	Anti Bait CoIP	18682553
Intra	Nr2c1	Q505F1	Nrip1	Mus musculus	Q8CBD1	Anti Tag CoIP	17187077
Intra	Nr2c1	Q505F1	Nrip1	Mus musculus	Q8CBD1	Y2H	17187077
Intra	Nr2c1	Q505F1	Nrip1	Mus musculus	Q8CBD1	Y2H	18682553
Intra	Nr2c1	Q505F1	Kat2b	Mus musculus	Q9JHD1	Interaction Detect	17187077
Intra	Nr2c1	Q505F1	Kat2b	Mus musculus	Q9JHD1	Y2H	17187077
Intra	Nr2c1	Q505F1	Kat2b	Mus musculus	Q9JHD1	Y2H	18682553
Intra	Nr2c1	Q505F1	Pias1	Mus musculus	O88907	Y2H	17187077
Intra	Nr2c1	Q505F1	Pias1	Mus musculus	O88907	Pull Down	17187077
Intra	Nr2c1	Q505F1	Pias1	Mus musculus	O88907	Anti Bait CoIP	17187077
Intra	Nr2c1	Q505F1	Pml	Mus musculus	Q60953	Anti Bait CoIP	17187077
Intra	Nr2c1	Q505F1	Sumo1	Mus musculus	P63166	Anti Bait CoIP	17187077
Intra	Nr2c1	Q505F1	Sumo1	Mus musculus	P63166	Anti Bait CoIP	18682553
Intra	Nr2c1	Q505F1	Sumo1	Mus musculus	P63166	Interaction Detect	17187077
Intra	Nr2c1	Q505F1	Ube2i	Mus musculus	P63280	Pull Down	17187077
Intra	Nr2c1	Q505F1	Ube2i	Mus musculus	P63280	Y2H	17187077
Intra	Nr2c1	Q505F1	Ube2i	Mus musculus	P63280	Anti Bait CoIP	17187077

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09536	NR2C1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nr2c1	NCBI	NCBI:7181

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