ECT2 - epithelial cell transforming 2 Gene

Homo sapiens

Also known as ARHGEF31

Gene ID: 1894 | Gene type: protein coding

About ECT2

Cytogenetic location: 3q26.31 Genomic coordinates (GRCh38): 3:172,750,726-172,829,265 (from NCBI)

This gene has 16 transcripts (splice variants) and 222 orthologues. Broad expression in testis (RPKM 6.4), colon (RPKM 5.0) and 24 other tissues.

Summary

The protein encoded by this gene is a guanine nucleotide exchange factor and transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]

ECT2 Products(14)

mRNA	Protein	Name
NM_001258315.2	NP_001245244.1	protein ECT2 isoform a
NM_001258316.2	NP_001245245.1	protein ECT2 isoform b
NM_001349094.2	NP_001336023.1	protein ECT2 isoform c
NM_001349095.2	NP_001336024.1	protein ECT2 isoform c
NM_001349096.2	NP_001336025.1	protein ECT2 isoform c
NM_001349097.2	NP_001336026.1	protein ECT2 isoform d
NM_001349098.2	NP_001336027.1	protein ECT2 isoform a
NM_001349099.2	NP_001336028.1	protein ECT2 isoform a
NM_001349100.2	NP_001336029.1	protein ECT2 isoform a
NM_001349101.2	NP_001336030.1	protein ECT2 isoform e
NM_001349102.2	NP_001336031.1	protein ECT2 isoform f
NM_001349103.2	NP_001336032.1	protein ECT2 isoform g
NM_001349104.2	NP_001336033.1	protein ECT2 isoform g
NM_018098.6	NP_060568.3	protein ECT2 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activator activity	IMP IMP: Inferred from mutant phenotype	15642749	GOA
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	15254234	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15254234	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	15545273	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of GTPase activity	IDA IDA: Inferred from direct assay	19617897	GOA
involved in activation of GTPase activity	IMP IMP: Inferred from mutant phenotype	19617897	GOA
involved in activation of protein kinase activity	IDA IDA: Inferred from direct assay	15254234	GOA
involved in bicellular tight junction assembly	IMP IMP: Inferred from mutant phenotype	15254234	GOA
involved in cellular response to calcium ion	IDA IDA: Inferred from direct assay	15254234	GOA
involved in cellular response to hydrogen peroxide	IDA IDA: Inferred from direct assay	21373644	GOA
involved in cellular response to ionizing radiation	IDA IDA: Inferred from direct assay	21373644	GOA
involved in mitotic cytokinesis	IMP IMP: Inferred from mutant phenotype	16236794	GOA
involved in positive regulation of GTPase activity	IDA IDA: Inferred from direct assay	17115030	GOA
involved in positive regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	21373644	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	21373644	GOA
involved in positive regulation of cytokinesis	IDA IDA: Inferred from direct assay	15545273	GOA
involved in positive regulation of cytokinesis	IMP IMP: Inferred from mutant phenotype	12761501	GOA
involved in positive regulation of mitotic cytokinetic process	IMP IMP: Inferred from mutant phenotype	16236794	GOA
involved in protein homooligomerization	IDA IDA: Inferred from direct assay	15545273	GOA
involved in regulation of attachment of spindle microtubules to kinetochore	IMP IMP: Inferred from mutant phenotype	15642749	GOA
involved in regulation of protein kinase activity	IDA IDA: Inferred from direct assay	15254234	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in bicellular tight junction	IDA IDA: Inferred from direct assay	15254234	GOA
located in cell-cell junction	IDA IDA: Inferred from direct assay	15254234	GOA
part of centralspindlin complex	IDA IDA: Inferred from direct assay	16236794	GOA
located in cleavage furrow	IDA IDA: Inferred from direct assay	16103226	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16394104	GOA
located in midbody	IDA IDA: Inferred from direct assay	15545273	GOA
located in mitotic spindle	IDA IDA: Inferred from direct assay	15254234	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15254234	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ECT2 Protein Structure

PTCB-BRCT

BRCT

RhoGEF

0
200
400
600
800
914 a.a.

Protein Preferred Names

Protein Names

protein ECT2

epithelial cell-transforming sequence 2 oncogene

ECT2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ECT2	Q9H8V3	KIF23	Homo sapiens	Q02241	Anti Bait CoIP	19468300
Intra	ECT2	Q9H8V3	KIF23	Homo sapiens	Q02241	Anti Bait CoIP	22750944
Intra	ECT2	Q9H8V3	NCK1	Homo sapiens	P16333	Peptide Array	17474147
Intra	ECT2	Q9H8V3	CTNNA1	Homo sapiens	P35221	Anti Bait CoIP	22750944
Intra	ECT2	Q9H8V3	RACGAP1	Homo sapiens	Q9H0H5	Anti Tag CoIP	19468302
Intra	ECT2	Q9H8V3	RACGAP1	Homo sapiens	Q9H0H5	Y2H	19468300
Intra	ECT2	Q9H8V3	RACGAP1	Homo sapiens	Q9H0H5	Anti Bait CoIP	19468300
Intra	ECT2	Q9H8V3	RACGAP1	Homo sapiens	Q9H0H5	ITC	25068414
Intra	ECT2	Q9H8V3	RACGAP1	Homo sapiens	Q9H0H5	Pull Down	19468300
Intra	ECT2	Q9H8V3	RACGAP1	Homo sapiens	Q9H0H5	Anti Bait CoIP	22750944
Intra	ECT2	Q9H8V3	CDH1	Homo sapiens	P12830	Anti Bait CoIP	22750944

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04149	ECT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04150	ECT2L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ECT2	VGNC	VGNC:72152
Felis catus	ECT2	VGNC	VGNC:61716
Bos taurus	ECT2	VGNC	VGNC:28314
Rattus norvegicus	ECT2	RGD	RGD:1308524
Canis familiaris	ECT2	VGNC	VGNC:40189
Mus musculus	ECT2	MGD	MGI:95281

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