KIF23 - kinesin family member 23 Gene

Homo sapiens

Also known as CHO1; KNSL5; MKLP1; CDAN3A; MKLP-1

Gene ID: 9493 | Gene type: protein coding

About KIF23

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:69,414,349-69,448,427 (from NCBI)

This gene has 16 transcripts (splice variants), 268 orthologues, 41 paralogues and is associated with 2 phenotypes. Broad expression in bone marrow (RPKM 9.3), testis (RPKM 8.0) and 17 other tissues.

Summary

The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]

KIF23 Products(5)

mRNA	Protein	Name
NM_001281301.2	NP_001268230.1	kinesin-like protein KIF23 isoform 3
NM_001367804.2	NP_001354733.1	kinesin-like protein KIF23 isoform 4
NM_001367805.3	NP_001354734.1	kinesin-like protein KIF23 isoform 5
NM_004856.7	NP_004847.2	kinesin-like protein KIF23 isoform 2
NM_138555.4	NP_612565.1	kinesin-like protein KIF23 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables microtubule binding	IDA IDA: Inferred from direct assay	11782313	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11782313	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mitotic cytokinesis	IMP IMP: Inferred from mutant phenotype	15843429	GOA
involved in mitotic spindle midzone assembly	IMP IMP: Inferred from mutant phenotype	16103226	GOA
involved in positive regulation of cytokinesis	IMP IMP: Inferred from mutant phenotype	16103226	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of centralspindlin complex	IDA IDA: Inferred from direct assay	11782313	GOA
located in centrosome	IDA IDA: Inferred from direct assay	20186884	GOA
located in midbody	IDA IDA: Inferred from direct assay	11782313	GOA
located in mitotic spindle	IDA IDA: Inferred from direct assay	16236794	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11782313	GOA
located in spindle	IDA IDA: Inferred from direct assay	15197175	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KIF23 Protein Structure

Kinesin

0
200
400
600
800
960 a.a.

Protein Preferred Names

Protein Names

kinesin-like protein KIF23

kinesin-like 5 (mitotic kinesin-like protein 1)

KIF23 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KIF23	Q02241	BIRC6	Homo sapiens	Q9NR09	IF	18329369
Intra	KIF23	Q02241	BIRC6	Homo sapiens	Q9NR09	Anti Bait CoIP	18329369
Intra	KIF23	Q02241	BIRC6	Homo sapiens	Q9NR09	Anti Tag CoIP	18329369
Intra	KIF23	Q02241	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	KIF23	Q02241	YWHAZ	Homo sapiens	P63104	Pull Down	20451386
Intra	KIF23	Q02241	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	26496610
Intra	KIF23	Q02241	YWHAG	Homo sapiens	P61981	CoIP	15324660
Intra	KIF23	Q02241	ARF6	Homo sapiens	P62330	Y2H	22580824
Intra	KIF23	Q02241	ARF6	Homo sapiens	P62330	IF	22522702
Intra	KIF23	Q02241	ARF6	Homo sapiens	P62330	Pull Down	22580824
Intra	KIF23	Q02241	RACGAP1	Homo sapiens	Q9H0H5	Density Sedimentation	11782313
Intra	KIF23	Q02241	RACGAP1	Homo sapiens	Q9H0H5	Anti Tag CoIP	26496610
Intra	KIF23	Q02241	RACGAP1	Homo sapiens	Q9H0H5	Y2H	22580824
Intra	KIF23	Q02241	RACGAP1	Homo sapiens	Q9H0H5	Anti Tag CoIP	35271311
Intra	KIF23	Q02241	RACGAP1	Homo sapiens	Q9H0H5	Anti Bait CoIP	18201571
Intra	KIF23	Q02241	RACGAP1	Homo sapiens	Q9H0H5	Anti Bait CoIP	11782313
Intra	KIF23	Q02241	RACGAP1	Homo sapiens	Q9H0H5	Pull Down	22580824
Cross	KIF23	Q02241	Arf6	Mus musculus	P62331	SAXS	22522702
Cross	KIF23	Q02241	Arf6	Mus musculus	P62331	Pull Down	22522702

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Anemia, Congenital Dyserythropoietic, Type Iiia

Congenital Dyserythropoietic Anemia, Type Iii	Cdan3
Congenital Dyserythropoietic Anemia Type Iii	Cda Iii
Congenital Dyserythropoietic Anemia Type 3	CDAN3A
Dyserythropoietic Anemia, Congenital, Type Iiia	Cda, Type Iiia
Anemia, Congenital Dyserythropoietic, Type Iii	Anemia With Multinucleated Erythroblasts
Cda Type 3	Cda Type Iii
Dyserythropoietic Anemia, Congenital Type 3	Cda, Type Iii
Erythroreticulosis, Hereditary Benign	Anaemia With Multinucleated Erythroblasts
Congenital Dyserythropoietic Anaemia Type 3	Congenital Dyserythropoietic Anaemia Type Iii
Hereditary Benign Erythroreticulosis	Anemia, Congenital Dyserythropoietic, 3a
Anemia With Multinucleated Erythroblasts Erythroreticulosis, Hereditary Benign

Anemia, Congenital Dyserythropoietic, Type Ia

Congenital Dyserythropoietic Anemia Type I	Cda I
CDAN1A	Congenital Dyserythropoietic Anemia Type 1
Congenital Dyserythropoietic Anemia Type Ia	Congenital Dyserythropoietic Anemia, Type I
Anemia, Congenital Dyserythropoietic, Type I	Cda Type 1
Cda Type I	Cda Ia
Dyserythropoietic Anemia, Congenital Type 1	Anemia, Congenital Dyserythropoietic, Type 1a
Dyserythropoietic Anemia, Congenital, Type Ia	Cda, Type Ia
Congenital Dyserythropoietic Anaemia Type 1	Congenital Dyserythropoietic Anaemia Type I
Anemia, Dyserythropoietic, Congenital Type 1	Type I Congenital Dyserythropoietic Anemia
Anemia, Congenital Dyserythropoietic, 1a	Anemia, Dyserythropoietic, Congenital, Type Ia

Anemia, Congenital Dyserythropoietic, Type Iv

CDAN4	Congenital Dyserythropoietic Anemia Type Iv
Congenital Dyserythropoietic Anemia Type 4	Cda Iv
Cda Due To Klf1 Mutation	Cda Type 4
Cda Type Iv	Congenital Dyserythropoietic Anemia Due To Klf1 Mutation
Cda, Type Iv	Dyserythropoietic Anemia, Congenital, Type Iv
Congenital Dyserythropoietic Anaemia Due To Klf1 Mutation	Congenital Dyserythropoietic Anaemia Type 4
Congenital Dyserythropoietic Anaemia Type Iv	Anemia, Congenital Dyserythropoietic, 4
Anemia, Dyserythropoietic Congenital, Type Iv	Anemia, Dyserythropoietic, Congenital, Type Iv

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Anemia, Congenital Dyserythropoietic, Type Ib

CDAN1B	Congenital Dyserythropoietic Anemia Type Ib
Cda, Type Ib	Congenital Dyserythropoietic Anemia Type Type 1b
Dyserythropoietic Anemia, Congenital, Type Ib	Anemia, Congenital Dyserythropoietic, 1b
Cda Ib	Anemia, Dyserythropoietic, Congenital
Anemia, Dyserythropoietic, Congenital, Type Ib

Anemia, Congenital Dyserythropoietic, Type Ii

Congenital Dyserythropoietic Anemia Type Ii	CDAN2
Cda Ii	Hereditary Erythroblastic Multinuclearity With Positive Acidified-Serum Test
Cda Type Ii	Congenital Dyserythropoietic Anemia Type 2
Hereditary Erythroblastic Multinuclearity With A Positive Acidified-Serum Test	Sec23b-Cdg
Congenital Dyserythropoietic Anemia, Type Ii	Dyserythropoietic Anemia, Hempas Type
Hempas	Cda Type 2
Dyserythropoietic Anemia, Congenital, Type Ii	Cda, Type Ii
Congenital Dyserythropoietic Anaemia Type 2	Congenital Dyserythropoietic Anaemia Type Ii
Anemia, Dyserythropoietic, Congenital Type 2	Hempas Anemia
Dyserythropoietic Anemia, Congenital Type 2	Anemia, Congenital Dyserythropoietic, 2
Dyserythropoietic Anemia Hempas Type	Anemia, Dyserythropoietic Congenital, Type Ii
Anemia, Dyserythropoietic, Congenital, Type Ii

Congenital Dyserythropoietic Anemia

Congenital Dyshaematopoietic Anaemia	Dyserythropoietic Anemia, Congenital
Cda	Anemia, Dyserythropoietic, Congenital
Anemia Dyserythropoietic Congenital	Cda - [Congenital Dyserythropoietic Anaemia]
Dyserythropoietic Dyshaematopoietic Congenital Anaemia	Dyshaematopoietic Anaemia
Dyserythropoietic Anaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07277	KIF23 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KIF23	MGD	MGI:1919069
Rattus norvegicus	KIF23	RGD	RGD:1308596
Canis familiaris	KIF23	VGNC	VGNC:59116
Macaca mulatta	KIF23	VGNC	VGNC:84364
Bos taurus	KIF23	VGNC	VGNC:55119
Felis catus	KIF23	VGNC	VGNC:80939

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