EEF1A2 - eukaryotic translation elongation factor 1 alpha 2 Gene

Homo sapiens

Also known as HS1; STN; EF1A; STNL; DEE33; MRD38; EEF1AL; EIEE33; EF-1-alpha-2

Gene ID: 1917 | Gene type: protein coding

About EEF1A2

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:63,488,014-63,499,083 (from NCBI)

This gene has 8 transcripts (splice variants), 180 orthologues, 18 paralogues and is associated with 5 phenotypes. Biased expression in heart (RPKM 211.2), brain (RPKM 133.2) and 3 other tissues.

Summary

This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the Other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas. This gene may be critical in the development of ovarian Cancer. [provided by RefSeq, Mar 2014]

EEF1A2 Products(1)

mRNA	Protein	Name
NM_001958.5	NP_001949.1	elongation factor 1-alpha 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18448518	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	17088255	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of lipid kinase activity	IDA IDA: Inferred from direct assay	17088255	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12426392	GOA
NOT located in nucleus	IDA IDA: Inferred from direct assay	12426392	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EEF1A2 Protein Structure

GTP_EFTU

GTP_EFTU_D2

GTP_EFTU_D3

0
100
200
300
400
463 a.a.

Protein Preferred Names

Protein Names

elongation factor 1-alpha 2

eukaryotic elongation factor 1 A-2

EEF1A2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EEF1A2	Q05639	ABTB1	Homo sapiens	Q969K4	Validated Y2H	32296183
Intra	EEF1A2	Q05639	ABTB1	Homo sapiens	Q969K4	Y2H Array	25416956
Intra	EEF1A2	Q05639	ABTB1	Homo sapiens	Q969K4	Anti Tag CoIP	33961781
Intra	EEF1A2	Q05639	ABTB1	Homo sapiens	Q969K4	Y2H Array	31515488
Intra	EEF1A2	Q05639	ABTB1	Homo sapiens	Q969K4	Validated Y2H	25416956
Intra	EEF1A2	Q05639	ABTB1	Homo sapiens	Q969K4	MAPPIT	32296183
Cross	EEF1A2	Q05639	N	Human SARS coronavirus	P59595	Anti Tag CoIP	18448518
Intra	EEF1A2	Q05639	TTLL12	Homo sapiens	Q14166	Validated Y2H	32296183
Intra	EEF1A2	Q05639	TTLL12	Homo sapiens	Q14166	Anti Tag CoIP	28514442
Intra	EEF1A2	Q05639	TTLL12	Homo sapiens	Q14166	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

EEF1A2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83134	Elongation Factor 1A2 Antibody (YA2879)	WB, IP	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Developmental And Epileptic Encephalopathy 33

DEE33	Epileptic Encephalopathy, Early Infantile, 33
Eiee33	Developmental And Epileptic Encephalopathy, 33
Early Infantile Epileptic Encephalopathy 33	Encephalopathy, Epileptic, Early Infantile, Type 33

Intellectual Developmental Disorder, Autosomal Dominant 38

Psychomotor Retardation, Epilepsy, And Language Disability Syndrome	MRD38
Prelds	Autosomal Dominant Non-Syndromic Intellectual Disability 38
Mental Retardation, Autosomal Dominant 38	Autosomal Dominant Intellectual Developmental Disorder 38
Autosomal Dominant Mental Retardation 38	Mental Retardation, Autosomal Dominant, Type 38

Ohtahara Syndrome

Developmental And Epileptic Encephalopathy

Encephalopathy, Developmental And Epileptic

Early Infantile Epileptic Encephalopathy

Early Infantile Epileptic Encephalopathy With Burst-Suppression	Early Infantile Epileptic Encephalopathy With Suppression Bursts
Eiee	Early Infantile Epileptic Encephalopathy With Suppression-Bursts
Ohtahara Syndrome	Encephalopathy, Epileptic, Early Infantile

Autosomal Dominant Non-Syndromic Intellectual Disability

Non-Specific Early-Onset Epileptic Encephalopathy

Undetermined Early-Onset Epileptic Encephalopathy	Non-Specific Eoee
Undetermined Eoee

Intrahepatic Biliary Papillomatosis

Intrahepatic Bile Duct Papillary Neoplasm

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Agenesis Of Corpus Callosum, Cardiac, Ocular, And Genital Syndrome

ACOGS

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16050	Plitidepsin	Inhibitor	99.99%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-120118	Metarrestin	Inhibitor	99.90%	Phase 1

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04175	EEF1A2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04176	EEF1B2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	EEF1A2	VGNC	VGNC:72163
Bos taurus	EEF1A2	VGNC	VGNC:50164
Mus musculus	EEF1A2	MGD	MGI:1096317
Felis catus	EEF1A2	VGNC	VGNC:61732
Rattus norvegicus	EEF1A2	RGD	RGD:3781

Name
Email *

	Sorry, but the email address you supplied was invalid.