ABTB1 - ankyrin repeat and BTB domain containing 1 Gene

Homo sapiens

Also known as BPOZ; BTB3; BTBD21; EF1ABP; PP2259

Gene ID: 80325 | Gene type: protein coding

About ABTB1

Cytogenetic location: 3q21.3 Genomic coordinates (GRCh38): 3:127,672,952-127,680,926 (from NCBI)

This gene has 15 transcripts (splice variants), 185 orthologues and 11 paralogues. Ubiquitous expression in spleen (RPKM 23.0), bone marrow (RPKM 13.1) and 25 other tissues.

Summary

This gene encodes a protein with an ankyrin repeat region and two BTB/POZ domains, which are thought to be involved in protein-protein interactions. Expression of this gene is activated by the Phosphatase and tensin homolog, a tumor suppressor. Alternate splicing results in three transcript variants. [provided by RefSeq, Mar 2010]

ABTB1 Products(2)

mRNA	Protein	Name
NM_032548.4	NP_115937.1	ankyrin repeat and BTB/POZ domain-containing protein 1 isoform 1
NM_172027.3	NP_742024.1	ankyrin repeat and BTB/POZ domain-containing protein 1 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21145461	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ABTB1 Protein Structure

Ank_5

BTB

0
100
200
300
400
478 a.a.

Protein Preferred Names

Protein Names

ankyrin repeat and BTB/POZ domain-containing protein 1

ankyrin repeat and BTB (POZ) domain containing 1

ABTB1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ABTB1	Q969K4	ZBTB21	Homo sapiens	Q9ULJ3	Anti Tag CoIP	33961781
Intra	ABTB1	Q969K4	ZBTB21	Homo sapiens	Q9ULJ3	Anti Tag CoIP	28514442
Intra	ABTB1	Q969K4	EEF1A2	Homo sapiens	Q05639	Y2H Prey Pooling	32296183
Intra	ABTB1	Q969K4	EEF1A2	Homo sapiens	Q05639	Y2H Array	32296183
Intra	ABTB1	Q969K4	EEF1A2	Homo sapiens	Q05639	Y2H Prey Pooling	25416956
Intra	ABTB1	Q969K4	EEF1A2	Homo sapiens	Q05639	Anti Tag CoIP	33961781
Intra	ABTB1	Q969K4	EEF1A2	Homo sapiens	Q05639	Anti Tag CoIP	28514442
Intra	ABTB1	Q969K4	EEF1D	Homo sapiens	P29692	Anti Tag CoIP	33961781
Intra	ABTB1	Q969K4	CUL3	Homo sapiens	Q13618	Validated Y2H	25416956
Intra	ABTB1	Q969K4	EEF1D	Homo sapiens	P29692-2	Y2H Array	32296183
Intra	ABTB1	Q969K4	EEF1D	Homo sapiens	P29692-2	Anti Tag CoIP	28514442
Intra	ABTB1	Q969K4	EEF1D	Homo sapiens	P29692-2	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00115	ABTB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ABTB1	RGD	RGD:1359363
Mus musculus	ABTB1	MGD	MGI:1933148
Felis catus	ABTB1	VGNC	VGNC:59494
Macaca mulatta	ABTB1	VGNC	VGNC:69459
Bos taurus	ABTB1	VGNC	VGNC:25515
Canis familiaris	ABTB1	VGNC	VGNC:37486

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