NSMCE1 - NSE1 homolog, SMC5-SMC6 complex component Gene

Homo sapiens

Also known as NSE1

Gene ID: 197370 | Gene type: protein coding

About NSMCE1

Cytogenetic location: 16p12.1 Genomic coordinates (GRCh38): 16:27,224,994-27,268,772 (from NCBI)

This gene has 14 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in testis (RPKM 20.3), prostate (RPKM 15.1) and 25 other tissues.

Summary

Enables protein dimerization activity and ubiquitin protein Ligase activity. Involved in positive regulation of response to DNA damage stimulus. Located in nucleoplasm. Part of Smc5-Smc6 complex. [provided by Alliance of Genome Resources, Apr 2022]

NSMCE1 Products(1)

mRNA	Protein	Name
NM_145080.4	NP_659547.2	non-structural maintenance of chromosomes element 1 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14701739	GOA
enables protein dimerization activity	IDA IDA: Inferred from direct assay	27427983	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	20864041	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	18086888	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Smc5-Smc6 complex	IDA IDA: Inferred from direct assay	18086888	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NSMCE1 Protein Structure

SMC_Nse1

zf-RING-like

0
100
200
266 a.a.

Protein Preferred Names

Protein Names

non-structural maintenance of chromosomes element 1 homolog

non-SMC element 1 homolog

NSMCE1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NSMCE1	Q8WV22	NSMCE3	Homo sapiens	Q96MG7	IF	20864041
Intra	NSMCE1	Q8WV22	NSMCE3	Homo sapiens	Q96MG7	GMS	18086888
Intra	NSMCE1	Q8WV22	NSMCE3	Homo sapiens	Q96MG7	Anti Tag CoIP	28514442
Intra	NSMCE1	Q8WV22	NSMCE3	Homo sapiens	Q96MG7	Pull Down	20864041
Intra	NSMCE1	Q8WV22	NSMCE3	Homo sapiens	Q96MG7	Crosslink	32389690
Intra	NSMCE1	Q8WV22	NSMCE3	Homo sapiens	Q96MG7	Anti Tag CoIP	33961781
Intra	NSMCE1	Q8WV22	NSMCE3	Homo sapiens	Q96MG7	Y2H	21364888
Intra	NSMCE1	Q8WV22	NSMCE3	Homo sapiens	Q96MG7	Anti Bait CoIP	18086888
Intra	NSMCE1	Q8WV22	SMC6	Homo sapiens	Q96SB8	Anti Tag CoIP	33961781
Intra	NSMCE1	Q8WV22	SMC6	Homo sapiens	Q96SB8	Anti Bait CoIP	18086888
Intra	NSMCE1	Q8WV22	SMC6	Homo sapiens	Q96SB8	GMS	18086888
Intra	NSMCE1	Q8WV22	SMC6	Homo sapiens	Q96SB8	Anti Tag CoIP	14701739

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Megalencephalic Leukoencephalopathy With Subcortical Cysts

Vacuolating Megalencephalic Leukoencephalopathy With Subcortical Cysts	Mlc
Van Der Knaap Disease	Lvm
Leukoencephalopathy With Swelling And Cysts	Megalencephaly-Cystic Leukodystrophy
Megalencephalic Leukodystrophy Megalencephaly-Cystic Leukodystorphy Syndrome	Infantile Leukoencephalopathy And Megalencephaly
Leukoencephalopathy With Swelling And A Discrepantly Mild Course	Vacuolating Leukoencephalopathy
Megalencephalic Leukodystrophy	Megalencephaly-Cystic Leukodystrophy Syndrome
Van Der Knaap Syndrome	Leukoencephalopathy, Megalencephalic, With Subcortical Cysts

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09597	NSMCE1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NSMCE1	VGNC	VGNC:63890
Rattus norvegicus	NSMCE1	RGD	RGD:1307760
Bos taurus	NSMCE1	VGNC	VGNC:32279
Mus musculus	NSMCE1	MGD	MGI:1914961
Macaca mulatta	NSMCE1	VGNC	VGNC:82091
Canis familiaris	NSMCE1	VGNC	VGNC:43988
Others	NSMCE1	NCBI

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