SMC6 - structural maintenance of chromosomes 6 Gene

Homo sapiens

Also known as SMC-6; hSMC6; SMC6L1

Gene ID: 79677 | Gene type: protein coding

About SMC6

Cytogenetic location: 2p24.2 Genomic coordinates (GRCh38): 2:17,663,812-17,753,810 (from NCBI)

This gene has 10 transcripts (splice variants), 218 orthologues and 1 paralogue. Broad expression in testis (RPKM 13.9), lymph node (RPKM 7.0) and 24 other tissues.

Summary

Enables ubiquitin protein Ligase binding activity. Involved in several processes, including cellular senescence; positive regulation of chromosome segregation; and telomere maintenance via recombination. Located in chromosome and nuclear body. Part of Smc5-Smc6 complex. [provided by Alliance of Genome Resources, Apr 2022]

SMC6 Products(2)

mRNA	Protein	Name
NM_001142286.2	NP_001135758.1	structural maintenance of chromosomes protein 6
NM_024624.6	NP_078900.1	structural maintenance of chromosomes protein 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA secondary structure binding	IDA IDA: Inferred from direct assay	28095508	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11408570	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	25931565	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	11408570	GOA
involved in cellular senescence	IMP IMP: Inferred from mutant phenotype	17589526	GOA
involved in negative regulation by host of viral genome replication	IDA IDA: Inferred from direct assay	28095508	GOA
involved in positive regulation of chromosome segregation	IMP IMP: Inferred from mutant phenotype	25931565	GOA
involved in telomere maintenance via recombination	IMP IMP: Inferred from mutant phenotype	17589526	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in PML body	IDA IDA: Inferred from direct assay	17589526	GOA
part of Smc5-Smc6 complex	IDA IDA: Inferred from direct assay	18086888	GOA
located in chromosome, telomeric region	IDA IDA: Inferred from direct assay	17589526	GOA
located in interchromatin granule	IDA IDA: Inferred from direct assay	11408570	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	28095508	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11408570	GOA
located in site of double-strand break	IDA IDA: Inferred from direct assay	25931565	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SMC6 Protein Structure

SMC_N

0
200
400
600
800
1000
1091 a.a.

Protein Preferred Names

Protein Names

structural maintenance of chromosomes protein 6

SMC protein 6

SMC6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SMC6	Q96SB8	NSMCE3	Homo sapiens	Q96MG7	Anti Bait CoIP	18086888
Intra	SMC6	Q96SB8	NSMCE3	Homo sapiens	Q96MG7	Anti Tag CoIP	27427983
Intra	SMC6	Q96SB8	NSMCE3	Homo sapiens	Q96MG7	Anti Tag CoIP	26496610
Intra	SMC6	Q96SB8	NSMCE1	Homo sapiens	Q8WV22	Anti Bait CoIP	18086888
Intra	SMC6	Q96SB8	NSMCE1	Homo sapiens	Q8WV22	Anti Tag CoIP	26496610
Intra	SMC6	Q96SB8	NSMCE2	Homo sapiens	Q96MF7	Anti Tag CoIP	33961781
Intra	SMC6	Q96SB8	NSMCE2	Homo sapiens	Q96MF7	Anti Bait CoIP	18086888
Intra	SMC6	Q96SB8	NSMCE2	Homo sapiens	Q96MF7	Anti Tag CoIP	26496610
Intra	SMC6	Q96SB8	SLF2	Homo sapiens	Q8IX21	Pull Down	32389690
Intra	SMC6	Q96SB8	SLF2	Homo sapiens	Q8IX21	Anti Tag CoIP	32389690
Intra	SMC6	Q96SB8	SLF2	Homo sapiens	Q8IX21	Anti Tag CoIP	26496610
Intra	SMC6	Q96SB8	SMC5	Homo sapiens	Q8IY18	Anti Tag CoIP	33961781
Intra	SMC6	Q96SB8	SMC5	Homo sapiens	Q8IY18	Anti Tag CoIP	26496610
Intra	SMC6	Q96SB8	SMC5	Homo sapiens	Q8IY18	Anti Bait CoIP	18086888

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Malignant Breast Melanoma

Malignant Melanoma Of Breast

Breast Melanoma

Fanconi Anemia, Complementation Group F

Fanconi Anemia Complementation Group F

FANCF

Cornelia De Lange Syndrome

De Lange Syndrome	Brachmann De Lange Syndrome
Brachmann-De Lange Syndrome	Cdls
Bdls	Typus Degenerativus Amstelodamensis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13422	SMC6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SMC6	MGD	MGI:1914491
Rattus norvegicus	SMC6	RGD	RGD:1311214
Bos taurus	SMC6	VGNC	VGNC:35003
Canis familiaris	SMC6	VGNC	VGNC:46547
Felis catus	SMC6	VGNC	VGNC:65480
Macaca mulatta	SMC6	VGNC	VGNC:77746

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