ELF1 - E74 like ETS transcription factor 1 Gene

Homo sapiens

Also known as RIA1; EFTUD1

Gene ID: 1997 | Gene type: protein coding

About ELF1

Cytogenetic location: 13q14.11 Genomic coordinates (GRCh38): 13:40,931,919-41,061,386 (from NCBI)

This gene has 5 transcripts (splice variants), 194 orthologues and 28 paralogues. Ubiquitous expression in bone marrow (RPKM 46.7), lymph node (RPKM 34.5) and 25 other tissues.

Summary

This gene encodes an E26 transformation-specific related transcription factor. The encoded protein is primarily expressed in lymphoid cells and acts as both an enhancer and a repressor to regulate transcription of various genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]

ELF1 Products(6)

mRNA	Protein	Name
NM_001145353.1	NP_001138825.1	ETS-related transcription factor Elf-1 isoform b
NM_001370329.1	NP_001357258.1	ETS-related transcription factor Elf-1 isoform c
NM_001370330.1	NP_001357259.1	ETS-related transcription factor Elf-1 isoform a
NM_001370331.1	NP_001357260.1	ETS-related transcription factor Elf-1 isoform a
NM_001370332.1	NP_001357261.1	ETS-related transcription factor Elf-1 isoform a
NM_172373.4	NP_758961.1	ETS-related transcription factor Elf-1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	8756667	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	14970218	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8756667	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10207087	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	19674970	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8756667	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	19674970	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ELF1 Protein Structure

Elf-1_N

Ets

0
100
200
300
400
500
619 a.a.

Protein Preferred Names

Protein Names

ETS-related transcription factor Elf-1

E74-like factor 1 (ets domain transcription factor)

ELF1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ELF1	P32519	NFYC	Homo sapiens	Q13952-2	Validated Y2H	32296183
Intra	ELF1	P32519	HOXC13	Homo sapiens	P31276	Pull Down	18692240
Intra	ELF1	P32519	HOXC13	Homo sapiens	P31276	Anti Tag CoIP	18692240
Intra	ELF1	P32519	SP1	Homo sapiens	P08047	Pull Down	10976766
Intra	ELF1	P32519	HSPBP1	Homo sapiens	Q9NZL4	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Intramuscular Hemangioma

Intramuscular Angioma	Hemangioma Intramuscular
Hemangioma, Intramuscular

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04298	ELF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ELF1	VGNC	VGNC:28426
Felis catus	ELF1	VGNC	VGNC:61805
Canis familiaris	ELF1	VGNC	VGNC:40298
Rattus norvegicus	ELF1	RGD	RGD:620697
Macaca mulatta	ELF1	VGNC	VGNC:72205
Mus musculus	ELF1	MGD	MGI:107180

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