ELK3 - ETS transcription factor ELK3 Gene

Homo sapiens

Also known as ERP; NET; SAP2; SAP-2

Gene ID: 2004 | Gene type: protein coding

About ELK3

Cytogenetic location: 12q23.1 Genomic coordinates (GRCh38): 12:96,194,375-96,269,824 (from NCBI)

This gene has 6 transcripts (splice variants), 204 orthologues and 28 paralogues. Ubiquitous expression in spleen (RPKM 23.7), endometrium (RPKM 22.8) and 24 other tissues.

Summary

This gene encodes a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

ELK3 Products(8)

mRNA	Protein	Name
NM_001303511.2	NP_001290440.1	ETS domain-containing protein Elk-3 isoform 2
NM_001413760.1	NP_001400689.1	ETS domain-containing protein Elk-3 isoform 1
NM_001413761.1	NP_001400690.1	ETS domain-containing protein Elk-3 isoform 1
NM_001413762.1	NP_001400691.1	ETS domain-containing protein Elk-3 isoform 3
NM_001413763.1	NP_001400692.1	ETS domain-containing protein Elk-3 isoform 4
NM_001413764.1	NP_001400693.1	ETS domain-containing protein Elk-3 isoform 5
NM_001413765.1	NP_001400694.1	ETS domain-containing protein Elk-3 isoform 6
NM_005230.4	NP_005221.2	ETS domain-containing protein Elk-3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12788937	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12933792	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12788937	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17474147	GOA
enables purine-rich negative regulatory element binding	IDA IDA: Inferred from direct assay	12933792	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12933792	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12788937	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in nucleus	IDA IDA: Inferred from direct assay	12933792	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ELK3 Protein Structure

Ets

0
100
200
300
407 a.a.

Protein Preferred Names

Protein Names

ETS domain-containing protein Elk-3

ELK3, ETS transcription factor

Related Diseases

Diseases

Alias

Yellow Nail Syndrome

Yns	Lymphedema And Yellow Nails
Lymphedema With Yellow Nails	Lymphedema-Yellow Nails
LYYN	Hereditary Lymphedema And Yellow Nails
Hereditary Lymphoedema And Yellow Nails

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107753	XRP44X	Inhibitor	98.42%	Unkown
HY-RS04306	ELK3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ELK3	VGNC	VGNC:28433
Canis familiaris	ELK3	VGNC	VGNC:40304
Macaca mulatta	ELK3	VGNC	VGNC:72210
Felis catus	ELK3	VGNC	VGNC:61811
Rattus norvegicus	ELK3	RGD	RGD:1307764
Mus musculus	ELK3	MGD	MGI:101762

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