BPIFA1 - BPI fold containing family A member 1 Gene

Homo sapiens

Also known as LUNX; NASG; PLUNC; SPURT; SPLUNC1; bA49G10.5

Gene ID: 51297 | Gene type: protein coding

About BPIFA1

Cytogenetic location: 20q11.21 Genomic coordinates (GRCh38): 20:33,235,996-33,243,306 (from NCBI)

This gene has 4 transcripts (splice variants), 113 orthologues and 12 paralogues. Biased expression in lung (RPKM 1.2), urinary bladder (RPKM 0.9) and 2 other tissues.

Summary

This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. The encoded antimicrobial protein displays Antibacterial activity against Gram-negative bacteria. It is thought to be involved in inflammatory responses to irritants in the upper airways and may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung Cancer. Multiple transcript variants resulting from alternative splicing in the 3' UTR have been detected, but the full-length nature of only three are known. [provided by RefSeq, Aug 2014]

BPIFA1 Products(3)

mRNA	Protein	Name
NM_001243193.2	NP_001230122.1	BPI fold-containing family A member 1 precursor
NM_016583.4	NP_057667.1	BPI fold-containing family A member 1 precursor
NM_130852.3	NP_570913.1	BPI fold-containing family A member 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antibacterial humoral response	IDA IDA: Inferred from direct assay	23499554	GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IEP IEP: Inferred from expression pattern	21805676	GOA
involved in defense response to virus	IEP IEP: Inferred from expression pattern	21805676	GOA
involved in immune response in nasopharyngeal-associated lymphoid tissue	IEP IEP: Inferred from expression pattern	21805676	GOA
involved in innate immune response	IDA IDA: Inferred from direct assay	23499554	GOA
involved in multicellular organismal-level water homeostasis	IDA IDA: Inferred from direct assay	24124190	GOA
involved in negative regulation of single-species biofilm formation in or on host organism	IMP IMP: Inferred from mutant phenotype	23499554	GOA
involved in regulation of sodium ion transmembrane transport	IDA IDA: Inferred from direct assay	24124190	GOA
involved in surfactant homeostasis	IDA IDA: Inferred from direct assay	23499554	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular region	IDA IDA: Inferred from direct assay	11425234	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	21805676	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BPIFA1 Protein Structure

LBP_BPI_CETP

0
100
200
256 a.a.

Protein Preferred Names

Protein Names

BPI fold-containing family A member 1

ligand-binding protein RYA3

BPIFA1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	BPIFA1	Q9NP55	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Array	25416956
Intra	BPIFA1	Q9NP55	TCF7L2	Homo sapiens	Q9NQB0-10	Validated Y2H	32296183
Intra	BPIFA1	Q9NP55	INIP	Homo sapiens	Q9NRY2	Validated Y2H	32296183
Intra	BPIFA1	Q9NP55	MTIF3	Homo sapiens	Q9H2K0	Y2H Array	32296183
Intra	BPIFA1	Q9NP55	MTIF3	Homo sapiens	Q9H2K0	Y2H Prey Pooling	32296183
Intra	BPIFA1	Q9NP55	PEF1	Homo sapiens	Q9UBV8	Validated Y2H	32296183
Intra	BPIFA1	Q9NP55	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32296183
Intra	BPIFA1	Q9NP55	UBQLN1	Homo sapiens	Q9UMX0	Y2H Prey Pooling	32296183
Intra	BPIFA1	Q9NP55	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	BPIFA1	Q9NP55	RSPH14	Homo sapiens	Q9UHP6	Validated Y2H	32296183
Intra	BPIFA1	Q9NP55	ALKBH4	Homo sapiens	Q9NXW9	Validated Y2H	32296183
Intra	BPIFA1	Q9NP55	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	BPIFA1	Q9NP55	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	BPIFA1	Q9NP55	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BPIFA1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700957	BPIFA1 Protein, Human	Q9NP55-1 (Q20-V256)	≥95%

Related Diseases

Diseases

Alias

Nasopharyngeal Carcinoma

Malignant Neoplasm Of Nasopharynx	Npc
Nasopharyngeal Cancer	Nasopharyngeal Carcinoma 1
Nasopharynx Carcinoma	Nasopharyngeal Neoplasms
Npca	Carcinoma Of Nasopharynx
Malignant Nasopharyngeal Tumor	Nasopharynx Cancer
Squamous Cell Carcinoma Of The Nasopharynx	Nasopharyngeal Neoplasm
Cancer Of Nasopharynx

Adenoiditis

Chronic Adenoiditis

Eye Disease

Eye Diseases	Abnormality Of The Eye
Toxoplasma Oculopathy

Chronic Purulent Otitis Media

Chronic Suppurative Otitis Media

Csom - [Chronic Suppurative Otitis Media]

Suppurative Otitis Media

Otitis Media With Effusion - Purulent	Purulent Otitis Media
Otitis Media, Suppurative

Hepatoid Adenocarcinoma

Papillary Cystadenocarcinoma

Cystadenocarcinoma, Papillary

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Lung Disease

Lung Diseases	Disorder Of Lung
Abnormality Of The Lung

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01581	BPIFA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	BPIFA1	VGNC	VGNC:70317
Canis familiaris	BPIFA1	VGNC	VGNC:38504
Felis catus	BPIFA1	VGNC	VGNC:60153
Rattus norvegicus	BPIFA1	RGD	RGD:619818
Mus musculus	BPIFA1	MGD	MGI:1338036
Bos taurus	BPIFA1	VGNC	VGNC:26543
Others	BPIFA1	NCBI

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