CENPX - centromere protein X Gene

Homo sapiens

Also known as D9; MHF2; CENP-X; FAAP10; STRA13

Gene ID: 201254 | Gene type: protein coding

About CENPX

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:82,018,703-82,022,878 (from NCBI)

This gene has 11 transcripts (splice variants) and 139 orthologues. Ubiquitous expression in prostate (RPKM 17.1), colon (RPKM 14.3) and 25 other tissues.

Summary

Enables DNA binding activity. Contributes to double-stranded DNA binding activity. Involved in replication fork processing and resolution of meiotic recombination intermediates. Part of FANCM-MHF complex and Fanconi anaemia nuclear complex. [provided by Alliance of Genome Resources, Apr 2022]

CENPX Products(4)

mRNA	Protein	Name
NM_001271006.2	NP_001257935.1	centromere protein X isoform 1
NM_001271007.2	NP_001257936.1	centromere protein X isoform 3
NM_001330536.2	NP_001317465.1	centromere protein X isoform 4
NM_144998.4	NP_659435.2	centromere protein X isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	20347429	GOA
contributes to double-stranded DNA binding	IDA IDA: Inferred from direct assay	20347428	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20347429	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in interstrand cross-link repair	IDA IDA: Inferred from direct assay	20347429	GOA
involved in replication fork processing	IMP IMP: Inferred from mutant phenotype	20347428	GOA
involved in resolution of meiotic recombination intermediates	IMP IMP: Inferred from mutant phenotype	20347428	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of FANCM-MHF complex	IDA IDA: Inferred from direct assay	20347428	GOA
part of FANCM-MHF complex	IPI IPI: Inferred from physical interaction	20347429	GOA
part of Fanconi anaemia nuclear complex	IDA IDA: Inferred from direct assay	20347428	GOA
located in chromatin	IDA IDA: Inferred from direct assay	20347429	GOA
part of inner kinetochore	IPI IPI: Inferred from physical interaction	36085283	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CENPX Protein Structure

CENP-X

0
81 a.a.

Protein Preferred Names

Protein Names

centromere protein X

FANCM associated histone fold protein 2

CENPX Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CENPX	A8MT69	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	25416956
Intra	CENPX	A8MT69	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	25416956
Intra	CENPX	A8MT69	REL	Homo sapiens	Q04864	Validated Y2H	25416956
Intra	CENPX	A8MT69	REL	Homo sapiens	Q04864	Y2H Array	25416956
Intra	CENPX	A8MT69	REL	Homo sapiens	Q04864	Y2H Prey Pooling	25416956
Intra	CENPX	A8MT69	CENPS	Homo sapiens	Q8N2Z9	SAXS	23886707
Intra	CENPX	A8MT69	CENPS	Homo sapiens	Q8N2Z9	GMS	22304917

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02495	CENPX Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CENPX	MGD	MGI:894324
Rattus norvegicus	CENPX	RGD	RGD:1590057
Macaca mulatta	CENPX	VGNC	VGNC:70934
Bos taurus	CENPX	VGNC	VGNC:27188

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