2. Gene
  3. ZSCAN4 - zinc finger and SCAN domain containing 4 Gene

ZSCAN4 - zinc finger and SCAN domain containing 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ZNF494

Gene ID: 201516 | Gene type: protein coding

About ZSCAN4

Cytogenetic location: 19q13.43 Genomic coordinates (GRCh38): 19:57,651,476-57,679,152 (from NCBI)

This gene has 1 transcript (splice variant), 31 orthologues and 31 paralogues. Low expression observed in reference dataset.

Summary

The ZSCAN4 gene encodes a protein involved in telomere maintenance and with a key role in the critical feature of mouse embryonic stem (ES) cells, namely, defying cellular senescence and maintaining normal karyotype for many cell divisions in culture (Zalzman et al., 2010 [PubMed 20336070]).[supplied by OMIM, May 2010]

ZSCAN4 Products(2)

mRNA Protein Name
NM_001384833.1 NP_001371762.1 zinc finger and SCAN domain-containing protein 4
NM_152677.4 NP_689890.1 zinc finger and SCAN domain-containing protein 4
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZSCAN4 Protein Structure

SCAN

SCAN: SCAN domain (40 - 129)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (326 - 349)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (354 - 379)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (382 - 405)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 433 a.a.
Protein Preferred Names Protein Names

zinc finger and SCAN domain-containing protein 4

zinc finger protein 494

ZSCAN4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ZSCAN4 Q8NAM6 CIB3 Homo sapiens Q96Q77
Validated Y2H
32296183
Intra
ZSCAN4 Q8NAM6 LAMTOR3 Homo sapiens Q9UHA4
Validated Y2H
32296183
Intra
ZSCAN4 Q8NAM6 FAM110A Homo sapiens Q9BQ89
Validated Y2H
32296183
Intra
ZSCAN4 Q8NAM6 PARD6B Homo sapiens Q9BYG5
Validated Y2H
32296183
Intra
ZSCAN4 Q8NAM6 TRAF3 Homo sapiens Q13114
Y2H Prey Pooling
32296183
Intra
ZSCAN4 Q8NAM6 TRAF3 Homo sapiens Q13114
Y2H Array
32296183
Intra
ZSCAN4 Q8NAM6 KAT5 Homo sapiens Q92993
Validated Y2H
32296183
Intra
ZSCAN4 Q8NAM6 EXOC8 Homo sapiens Q8IYI6
Y2H Prey Pooling
32296183
Intra
ZSCAN4 Q8NAM6 EXOC8 Homo sapiens Q8IYI6
Y2H Array
32296183
Intra
ZSCAN4 Q8NAM6 TBC1D22B Homo sapiens Q9NU19
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Facioscapulohumeral Muscular Dystrophy 1

Facioscapulohumeral Muscular Dystrophy

Fshd

Landouzy-Dejerine Muscular Dystrophy

Muscular Dystrophy, Facioscapulohumeral

FSHD1

Fshd1a

Muscular Dystrophy, Facioscapulohumeral, Type 1a

Facioscapulohumeral Muscular Dystrophy Type 1a

Fsh Muscular Dystrophy

Facioscapulohumeral Muscular Dystrophy 1a

Facioscapulohumeral Atrophy

Facioscapulohumeral Myopathy

Muscular Dystrophy, Facioscapulohumeral, Type 1

Facioscapulohumeral Muscular Dystrophy Type 1

Landouzy Dejerine Muscular Dystrophy

Muscular Dystrophy, Landouzy-Dejerine

Fshmd1a

Facio-Scapulo-Humeral Dystrophy

Facioscapulohumeral Type Progressive Muscular Dystrophy

Facioscapuloperoneal Muscular Dystrophy

Facioscapulohumeral Dystrophy

Fsh Dystrophy

Landouzy-Dejerine Dystrophy

Landouzy-Dejerine Myopathy

Fmd

Facioscapulohumeral Muscular Dystrophy-1a

Muscular Dystrophy Facioscapulohumeral

Dystrophy, Muscular, Facioscapulohumeral

Dystrophy, Muscular, Facioscapulohumeral, Type 1

Landouzy-Dejerine Disease

Landouzy-Déjerine Atrophy

Facioscapulohumeral Muscle Dystrophy

Fmd - [Facioscapulohumeral Muscular Dystrophy]

Fsh - [Facioscapulohumeral Muscular Dystrophy]

Fshd - [Facioscapulohumeral Muscular Dystrophy]

Landouzy-Déjerine Dystrophy Or Facioscapulohumeral Atrophy

Landouzy-Déjérine Muscular Dystrophy
Facioscapulohumeral Muscular Dystrophy 2, Digenic

Facioscapulohumeral Muscular Dystrophy 2

FSHD2

Fshd1b

Facioscapulohumeral Muscular Dystrophy 1b

Fshd2, Digenic

Muscular Dystrophy, Facioscapulohumeral, Type 2

Muscular Dystrophy, Facioscapulohumeral, Type 1b

Fascioscapulohumeral Muscular Dystrophy 2, Digenic

Facioscapulohumeral Muscular Dystrophy Type 2

Digenic Facioscapulohumeral Muscular Dystrophy

Digenic Fshd2

Facioscapulohumeral Muscular Dystrophy Type 1b

Dystrophy, Muscular, Facioscapulohumeral, Type 2
Digenic Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS16202 ZSCAN4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ZSCAN4 RGD RGD:1563625
Bos taurus ZSCAN4 VGNC VGNC:52275
Macaca mulatta ZSCAN4 VGNC VGNC:79403