PARD6B - par-6 family cell polarity regulator beta Gene

Homo sapiens

Also known as PAR6B

Gene ID: 84612 | Gene type: protein coding

About PARD6B

Cytogenetic location: 20q13.13 Genomic coordinates (GRCh38): 20:50,731,580-50,753,741 (from NCBI)

This gene has 2 transcripts (splice variants), 208 orthologues and 2 paralogues. Broad expression in kidney (RPKM 9.5), lung (RPKM 3.4) and 17 other tissues.

Summary

This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. [provided by RefSeq, Jul 2008]

PARD6B Products(1)

mRNA	Protein	Name
NM_032521.3	NP_115910.1	partitioning defective 6 homolog beta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11260256	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	12545177	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in bicellular tight junction	IDA IDA: Inferred from direct assay	12545177	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12545177	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PARD6B Protein Structure

PB1

PDZ

0
100
200
300
372 a.a.

Protein Preferred Names

Protein Names

partitioning defective 6 homolog beta

PAR-6 beta

PARD6B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PARD6B	Q9BYG5	FLJ13057	Homo sapiens	Q53SE7	Y2H Prey Pooling	25416956
Intra	PARD6B	Q9BYG5	BANP	Homo sapiens	Q8N9N5-2	Y2H Prey Pooling	32296183
Intra	PARD6B	Q9BYG5	BANP	Homo sapiens	Q8N9N5-2	Y2H Array	32296183
Intra	PARD6B	Q9BYG5	FRMD6	Homo sapiens	Q96NE9-2	Y2H Prey Pooling	32296183
Intra	PARD6B	Q9BYG5	FRMD6	Homo sapiens	Q96NE9-2	Y2H Array	32296183
Intra	PARD6B	Q9BYG5	TRIM35	Homo sapiens	Q9UPQ4-2	Y2H Prey Pooling	32296183
Intra	PARD6B	Q9BYG5	TRIM35	Homo sapiens	Q9UPQ4-2	Validated Y2H	32296183
Intra	PARD6B	Q9BYG5	CDCA4	Homo sapiens	Q9BXL8	Y2H Array	32296183
Intra	PARD6B	Q9BYG5	CDCA4	Homo sapiens	Q9BXL8	Y2H Prey Pooling	32296183
Intra	PARD6B	Q9BYG5	GMCL1	Homo sapiens	Q96IK5	Y2H Array	32296183
Intra	PARD6B	Q9BYG5	GMCL1	Homo sapiens	Q96IK5	Y2H Prey Pooling	32296183
Intra	PARD6B	Q9BYG5	RASSF3	Homo sapiens	Q86WH2	Y2H Array	32296183
Intra	PARD6B	Q9BYG5	RASSF3	Homo sapiens	Q86WH2	Y2H Prey Pooling	32296183
Intra	PARD6B	Q9BYG5	PRKCI	Homo sapiens	P41743	Anti Tag CoIP	33961781
Intra	PARD6B	Q9BYG5	PRKCI	Homo sapiens	P41743	Y2H Array	32296183
Intra	PARD6B	Q9BYG5	PRKCI	Homo sapiens	P41743	Anti Tag CoIP	28514442
Intra	PARD6B	Q9BYG5	PRKCI	Homo sapiens	P41743	Y2H Prey Pooling	25416956
Intra	PARD6B	Q9BYG5	PRKCI	Homo sapiens	P41743	Anti Tag CoIP	14676191
Intra	PARD6B	Q9BYG5	PRKCI	Homo sapiens	P41743	Y2H Prey Pooling	32296183
Intra	PARD6B	Q9BYG5	PRKCI	Homo sapiens	P41743	Anti Tag CoIP	26496610
Intra	PARD6B	Q9BYG5	PRKCI	Homo sapiens	P41743	Y2H Array	25416956
Intra	PARD6B	Q9BYG5	PRKCZ	Homo sapiens	Q05513	Y2H Prey Pooling	32296183
Intra	PARD6B	Q9BYG5	PRKCZ	Homo sapiens	Q05513	Pull Down	11260256
Intra	PARD6B	Q9BYG5	PRKCZ	Homo sapiens	Q05513	Anti Tag CoIP	33961781
Intra	PARD6B	Q9BYG5	PRKCZ	Homo sapiens	Q05513	Y2H Array	32296183
Intra	PARD6B	Q9BYG5	PRKCZ	Homo sapiens	Q05513	Anti Tag CoIP	28514442
Intra	PARD6B	Q9BYG5	PRKCZ	Homo sapiens	Q05513	Anti Tag CoIP	14676191
Intra	PARD6B	Q9BYG5	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	26496610
Intra	PARD6B	Q9BYG5	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	14676191
Intra	PARD6B	Q9BYG5	TRIB3	Homo sapiens	Q96RU7	Y2H Array	32296183
Intra	PARD6B	Q9BYG5	TRIB3	Homo sapiens	Q96RU7	Y2H Prey Pooling	32296183
Intra	PARD6B	Q9BYG5	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	PARD6B	Q9BYG5	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	PARD6B	Q9BYG5	RHOJ	Homo sapiens	Q9H4E5	Y2H Prey Pooling	25416956
Intra	PARD6B	Q9BYG5	RHOJ	Homo sapiens	Q9H4E5	Validated Y2H	32296183
Intra	PARD6B	Q9BYG5	RHOQ	Homo sapiens	P17081	Y2H Array	32296183
Intra	PARD6B	Q9BYG5	RHOQ	Homo sapiens	P17081	Y2H Prey Pooling	32296183
Intra	PARD6B	Q9BYG5	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	PARD6B	Q9BYG5	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	PARD6B	Q9BYG5	ZSCAN4	Homo sapiens	Q8NAM6	Y2H Array	32296183
Intra	PARD6B	Q9BYG5	ZSCAN4	Homo sapiens	Q8NAM6	Y2H Prey Pooling	32296183
Intra	PARD6B	Q9BYG5	CEP76	Homo sapiens	Q8TAP6	Y2H Array	25416956
Intra	PARD6B	Q9BYG5	CEP76	Homo sapiens	Q8TAP6	Y2H Prey Pooling	25416956
Intra	PARD6B	Q9BYG5	CEP76	Homo sapiens	Q8TAP6	Y2H Prey Pooling	32296183
Intra	PARD6B	Q9BYG5	CEP76	Homo sapiens	Q8TAP6	Y2H Array	32296183
Intra	PARD6B	Q9BYG5	MAGOHB	Homo sapiens	Q96A72	Y2H Array	32296183
Intra	PARD6B	Q9BYG5	MAGOHB	Homo sapiens	Q96A72	Y2H Prey Pooling	32296183
Intra	PARD6B	Q9BYG5	RAC3	Homo sapiens	P60763	Y2H Prey Pooling	32296183
Intra	PARD6B	Q9BYG5	RAC3	Homo sapiens	P60763	Y2H Array	32296183
Intra	PARD6B	Q9BYG5	CDC42	Homo sapiens	P60953	Y2H Array	32296183
Intra	PARD6B	Q9BYG5	CDC42	Homo sapiens	P60953	Y2H Prey Pooling	25416956
Intra	PARD6B	Q9BYG5	CDC42	Homo sapiens	P60953	Anti Tag CoIP	14676191
Intra	PARD6B	Q9BYG5	CDC42	Homo sapiens	P60953	Y2H Array	25416956
Intra	PARD6B	Q9BYG5	CDC42	Homo sapiens	P60953	Y2H Prey Pooling	32296183
Intra	PARD6B	Q9BYG5	CDC42	Homo sapiens	P60953	Y2H Pooling	20936779
Intra	PARD6B	Q9BYG5	PARD3	Homo sapiens	Q8TEW0	Anti Tag CoIP	33961781
Intra	PARD6B	Q9BYG5	PARD3	Homo sapiens	Q8TEW0	Anti Tag CoIP	26496610
Intra	PARD6B	Q9BYG5	PARD3	Homo sapiens	Q8TEW0	Anti Tag CoIP	14676191

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10039	PARD6B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PARD6B	VGNC	VGNC:107850
Rattus norvegicus	PARD6B	RGD	RGD:1308205
Canis familiaris	PARD6B	VGNC	VGNC:54725
Bos taurus	PARD6B	VGNC	VGNC:32584
Mus musculus	PARD6B	MGD	MGI:2135605

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