2. Gene
  3. CIB3 - calcium and integrin binding family member 3 Gene

CIB3 - calcium and integrin binding family member 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as KIP3

Gene ID: 117286 | Gene type: protein coding

About CIB3

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:16,161,368-16,173,525 (from NCBI)

This gene has 4 transcripts (splice variants), 197 orthologues and 8 paralogues. Low expression observed in reference dataset.

Summary

This gene product shares a high degree of sequence similarity with DNA-dependent protein kinase catalytic subunit-interacting protein 2 in human and mouse, and like them may bind the catalytic subunit of DNA-dependent protein kinases. The exact function of this gene is not known. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

CIB3 Products(2)

mRNA Protein Name
NM_001300922.2 NP_001287851.1 calcium and integrin-binding family member 3 isoform 2
NM_054113.4 NP_473454.1 calcium and integrin-binding family member 3 isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
22779914 GOA
enables magnesium ion binding IDA
IDA: Inferred from direct assay
22779914 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22779914 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CIB3 Protein Structure

EF-hand_7

EF-hand_7: EF-hand domain pair (111 - 173)

  • 0
  • 100
  • 187 a.a.
Protein Preferred Names Protein Names

calcium and integrin-binding family member 3

DNA-dependent protein kinase catalytic subunit-interacting protein 3

CIB3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CIB3 Q96Q77 ENOX2 Homo sapiens Q16206-2
Validated Y2H
25416956
Intra
CIB3 Q96Q77 ENOX2 Homo sapiens Q16206-2
Y2H Array
25416956
Intra
CIB3 Q96Q77 BEND7 Homo sapiens Q8N7W2-2
Validated Y2H
25416956
Intra
CIB3 Q96Q77 BEND7 Homo sapiens Q8N7W2-2
Y2H Array
25416956
Intra
CIB3 Q96Q77 SP4 Homo sapiens Q02446
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 SP4 Homo sapiens Q02446
Y2H Array
32296183
Intra
CIB3 Q96Q77 ZNF774 Homo sapiens Q6NX45
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 ZNF774 Homo sapiens Q6NX45
Y2H Array
32296183
Intra
CIB3 Q96Q77 KLF17 Homo sapiens Q5JT82
Validated Y2H
25416956
Intra
CIB3 Q96Q77 KLF17 Homo sapiens Q5JT82
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 KLF17 Homo sapiens Q5JT82
Y2H Array
32296183
Intra
CIB3 Q96Q77 TLE5 Homo sapiens Q08117-2
Y2H Array
32296183
Intra
CIB3 Q96Q77 TLE5 Homo sapiens Q08117-2
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 ZNF146 Homo sapiens Q15072
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 ZNF146 Homo sapiens Q15072
Y2H Array
32296183
Intra
CIB3 Q96Q77 ARMC8 Homo sapiens Q8IUR7-6
Y2H Array
32296183
Intra
CIB3 Q96Q77 ARMC8 Homo sapiens Q8IUR7-6
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 ZNF578 Homo sapiens Q96N58
Y2H Array
32296183
Intra
CIB3 Q96Q77 ZNF578 Homo sapiens Q96N58
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 POU6F2 Homo sapiens P78424
Y2H Array
32296183
Intra
CIB3 Q96Q77 ZNF180 Homo sapiens Q9UJW8-4
Validated Y2H
32296183
Intra
CIB3 Q96Q77 ZNF180 Homo sapiens Q9UJW8-4
Y2H Array
32296183
Intra
CIB3 Q96Q77 ZNF180 Homo sapiens Q9UJW8-4
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 RBAK Homo sapiens Q9NYW8
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 RBAK Homo sapiens Q9NYW8
Validated Y2H
32296183
Intra
CIB3 Q96Q77 RBAK Homo sapiens Q9NYW8
Y2H Array
32296183
Intra
CIB3 Q96Q77 ZNF317 Homo sapiens Q96PQ6
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 ZNF317 Homo sapiens Q96PQ6
Y2H Array
32296183
Intra
CIB3 Q96Q77 ZNF177 Homo sapiens Q13360-2
Y2H Array
32296183
Intra
CIB3 Q96Q77 ZNF177 Homo sapiens Q13360-2
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 C17orf50 Homo sapiens Q8WW18
Y2H Array
32296183
Intra
CIB3 Q96Q77 C17orf50 Homo sapiens Q8WW18
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 ZFP57 Homo sapiens Q9NU63-3
Y2H Array
32296183
Intra
CIB3 Q96Q77 ZFP57 Homo sapiens Q9NU63-3
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 ZFP57 Homo sapiens Q9NU63-3
Validated Y2H
32296183
Intra
CIB3 Q96Q77 ZNF19 Homo sapiens P17023
Y2H Array
32296183
Intra
CIB3 Q96Q77 ZNF19 Homo sapiens P17023
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 ZC2HC1C Homo sapiens Q53FD0-2
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 ZC2HC1C Homo sapiens Q53FD0-2
Y2H Array
32296183
Intra
CIB3 Q96Q77 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
CIB3 Q96Q77 NANOS3 Homo sapiens P60323-2
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 NANOS3 Homo sapiens P60323-2
Y2H Array
32296183
Intra
CIB3 Q96Q77 GMCL1 Homo sapiens Q96IK5
Y2H Array
32296183
Intra
CIB3 Q96Q77 GMCL1 Homo sapiens Q96IK5
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 TACC3 Homo sapiens Q9Y6A5
Y2H Prey Pooling
25416956
Intra
CIB3 Q96Q77 TACC3 Homo sapiens Q9Y6A5
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 TACC3 Homo sapiens Q9Y6A5
Y2H Array
32296183
Intra
CIB3 Q96Q77 TACC3 Homo sapiens Q9Y6A5
Validated Y2H
25416956
Intra
CIB3 Q96Q77 TACC3 Homo sapiens Q9Y6A5
Validated Y2H
32296183
Intra
CIB3 Q96Q77 ZNF552 Homo sapiens Q9H707
Validated Y2H
32296183
Intra
CIB3 Q96Q77 ZNF552 Homo sapiens Q9H707
Y2H Array
32296183
Intra
CIB3 Q96Q77 ZNF552 Homo sapiens Q9H707
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 ZFP1 Homo sapiens Q6P2D0
Y2H Array
32296183
Intra
CIB3 Q96Q77 ZFP1 Homo sapiens Q6P2D0
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 ZNF664 Homo sapiens Q8N3J9
Y2H Array
32296183
Intra
CIB3 Q96Q77 ZNF664 Homo sapiens Q8N3J9
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 SYPL1 Homo sapiens Q16563
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 SYPL1 Homo sapiens Q16563
Y2H Array
32296183
Intra
CIB3 Q96Q77 TRIM14 Homo sapiens Q14142
Y2H Array
32296183
Intra
CIB3 Q96Q77 TRIM14 Homo sapiens Q14142
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 SERTAD1 Homo sapiens Q53GC0
Y2H Prey Pooling
25416956
Intra
CIB3 Q96Q77 SERTAD1 Homo sapiens Q53GC0
Validated Y2H
25416956
Intra
CIB3 Q96Q77 MEOX1 Homo sapiens P50221
Y2H Array
25416956
Intra
CIB3 Q96Q77 PAX5 Homo sapiens Q02548
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 PAX5 Homo sapiens Q02548
Y2H Array
32296183
Intra
CIB3 Q96Q77 REL Homo sapiens Q04864
Y2H Array
25416956
Intra
CIB3 Q96Q77 POLR2G Homo sapiens P62487
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 POLR2G Homo sapiens P62487
Y2H Array
32296183
Intra
CIB3 Q96Q77 SP3 Homo sapiens Q02447
Y2H Array
32296183
Intra
CIB3 Q96Q77 SP3 Homo sapiens Q02447
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 SLPI Homo sapiens P03973
Y2H Array
32296183
Intra
CIB3 Q96Q77 SLPI Homo sapiens P03973
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 ZNF620 Homo sapiens Q6ZNG0
Y2H Array
32296183
Intra
CIB3 Q96Q77 ZNF620 Homo sapiens Q6ZNG0
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 ZNF688 Homo sapiens P0C7X2
Y2H Array
32296183
Intra
CIB3 Q96Q77 ZNF688 Homo sapiens P0C7X2
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 TRAF5 Homo sapiens O00463
Y2H Array
32296183
Intra
CIB3 Q96Q77 TRAF5 Homo sapiens O00463
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 ZNF835 Homo sapiens Q9Y2P0
Y2H Array
32296183
Intra
CIB3 Q96Q77 ZNF835 Homo sapiens Q9Y2P0
Validated Y2H
32296183
Intra
CIB3 Q96Q77 ZNF835 Homo sapiens Q9Y2P0
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 TLE5 Homo sapiens Q08117
Validated Y2H
25416956
Intra
CIB3 Q96Q77 TLE5 Homo sapiens Q08117
Y2H Array
25416956
Intra
CIB3 Q96Q77 TLE5 Homo sapiens Q08117
Y2H Prey Pooling
25416956
Intra
CIB3 Q96Q77 ZNF329 Homo sapiens Q86UD4
Y2H Array
32296183
Intra
CIB3 Q96Q77 ZNF329 Homo sapiens Q86UD4
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 ZSCAN4 Homo sapiens Q8NAM6
Y2H Array
32296183
Intra
CIB3 Q96Q77 ZSCAN4 Homo sapiens Q8NAM6
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
25416956
Intra
CIB3 Q96Q77 ZBTB43 Homo sapiens O43298
Y2H Array
32296183
Intra
CIB3 Q96Q77 ZBTB43 Homo sapiens O43298
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 ZNF426 Homo sapiens Q9BUY5
Y2H Array
25416956
Intra
CIB3 Q96Q77 NME4 Homo sapiens O00746
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 NME4 Homo sapiens O00746
Y2H Array
32296183
Intra
CIB3 Q96Q77 PAX6 Homo sapiens P26367
Y2H Array
32296183
Intra
CIB3 Q96Q77 PAX6 Homo sapiens P26367
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 SCNM1 Homo sapiens Q9BWG6
Y2H Array
32296183
Intra
CIB3 Q96Q77 SCNM1 Homo sapiens Q9BWG6
Validated Y2H
32296183
Intra
CIB3 Q96Q77 SCNM1 Homo sapiens Q9BWG6
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 MEOX2 Homo sapiens P50222
Validated Y2H
25416956
Intra
CIB3 Q96Q77 MEOX2 Homo sapiens P50222
Y2H Prey Pooling
25416956
Intra
CIB3 Q96Q77 SERTAD1 Homo sapiens Q9UHV2
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 SERTAD1 Homo sapiens Q9UHV2
Validated Y2H
32296183
Intra
CIB3 Q96Q77 SERTAD1 Homo sapiens Q9UHV2
Y2H Array
32296183
Intra
CIB3 Q96Q77 KASH5 Homo sapiens Q8N6L0
Y2H Prey Pooling
25416956
Intra
CIB3 Q96Q77 KASH5 Homo sapiens Q8N6L0
Validated Y2H
25416956
Intra
CIB3 Q96Q77 TRIM2 Homo sapiens Q9C040
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 TRIM2 Homo sapiens Q9C040
Validated Y2H
32296183
Intra
CIB3 Q96Q77 TRIM2 Homo sapiens Q9C040
Y2H Array
32296183
Intra
CIB3 Q96Q77 TRIM2 Homo sapiens Q9C040
Y2H Array
25416956
Intra
CIB3 Q96Q77 ZNF276 Homo sapiens Q8N554
Y2H Array
32296183
Intra
CIB3 Q96Q77 ZNF276 Homo sapiens Q8N554
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 ZNF398 Homo sapiens Q8TD17
Y2H Array
25416956
Intra
CIB3 Q96Q77 ZNF398 Homo sapiens Q8TD17
Y2H Array
32296183
Intra
CIB3 Q96Q77 ZNF398 Homo sapiens Q8TD17
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 ZSCAN5A Homo sapiens Q9BUG6
Y2H Prey Pooling
32296183
Intra
CIB3 Q96Q77 ZSCAN5A Homo sapiens Q9BUG6
Y2H Array
32296183
Intra
CIB3 Q96Q77 ZSCAN5A Homo sapiens Q9BUG6
Validated Y2H
32296183
Intra
CIB3 Q96Q77 ZNF597 Homo sapiens Q96LX8
Y2H Array
32296183
Intra
CIB3 Q96Q77 ZNF597 Homo sapiens Q96LX8
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Usher Syndrome, Type Ij

Usher Syndrome Type 1j

USH1J

Usher Syndrome Type Ij

Usher Syndrome 1j

Usher'S Syndrome Type 1j
Colon Small Cell Carcinoma

Colonic Small Cell Carcinoma

Colon Small Cell Neuroendocrine Carcinoma
Congenital Fibrosis Of The Extraocular Muscles

Congenital Fibrosis Of Extraocular Muscles

Cfeom

Feom

Congenital External Ophthalmoplegia

Congenital Fibrosis Syndrome

General Fibrosis Syndrome
Usher Syndrome, Type I

USH1

Usher Syndrome Type 1

Us1

Usher Syndrome, Type 1b

Usher Syndrome Type 1e

Retinitis Pigmentosa And Congenital Deafness

Usher Syndrome, Type Ie

USH1E

Usher Syndrome, Type 1e

Usher Syndrome, Type 1a

Usher Syndrome, Type Ib

Usher Syndrome Type 1b

Usher Syndrome Type Ie

Usher Syndrome Type I

Usher 1

Usher Syndrome, Type 1

Ush1a

Usher Syndrome, Type I, French Variety

Usher Syndrome, Type Ia

Usher Syndrome 1b

USH1B

Usher'S Syndrome Type 1b

Usher Syndrome Type Ib

Ushib
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-147918 Anticancer agent 73 Inhibitor 99.92% Unkown
HY-RS02708 CIB3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CIB3 VGNC VGNC:39268
Bos taurus CIB3 VGNC VGNC:27361
Felis catus CIB3 VGNC VGNC:69375
Mus musculus CIB3 MGD MGI:2685953
Macaca mulatta CIB3 VGNC VGNC:71339
Rattus norvegicus CIB3 RGD RGD:1590245