2. Gene
  3. TRAF3 - TNF receptor associated factor 3 Gene

TRAF3 - TNF receptor associated factor 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CAP1; LAP1; CAP-1; CRAF1; IIAE5; CD40bp; RNF118

Gene ID: 7187 | Gene type: protein coding

About TRAF3

Cytogenetic location: 14q32.32 Genomic coordinates (GRCh38): 14:102,777,449-102,911,500 (from NCBI)

This gene has 13 transcripts (splice variants), 135 orthologues, 5 paralogues and is associated with 2 phenotypes. Ubiquitous expression in lymph node (RPKM 5.0), appendix (RPKM 4.8) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the TNF Receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF Receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent Infection membrane protein-1 (LMP1) can interact with this and several Other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. The protein also plays a role in the regulation of Antiviral response. Mutations in this are associated with Encephalopathy, acute, infection-induced, herpes-specific 5. [provided by RefSeq, Jul 2020]

TRAF3 Products(6)

mRNA Protein Name
NM_001199427.2 NP_001186356.1 TNF receptor-associated factor 3 isoform 3
NM_001385142.1 NP_001372071.1 TNF receptor-associated factor 3 isoform 4
NM_001385143.1 NP_001372072.1 TNF receptor-associated factor 3 isoform 5
NM_003300.4 NP_003291.2 TNF receptor-associated factor 3 isoform 1
NM_145725.3 NP_663777.1 TNF receptor-associated factor 3 isoform 1
NM_145726.3 NP_663778.1 TNF receptor-associated factor 3 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
7527023 GOA
enables protein phosphatase binding IPI
IPI: Inferred from physical interaction
23871208 GOA
enables thioesterase binding IPI
IPI: Inferred from physical interaction
11279055 GOA
enables tumor necrosis factor receptor binding IPI
IPI: Inferred from physical interaction
11728344 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
19898473 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
11279055 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
19898473 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
20185819 GOA
involved in positive regulation of type I interferon production IDA
IDA: Inferred from direct assay
19898473 GOA
involved in regulation of proteolysis IMP
IMP: Inferred from mutant phenotype
20185819 GOA
involved in toll-like receptor 4 signaling pathway IDA
IDA: Inferred from direct assay
18222170 GOA
involved in tumor necrosis factor-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
20185819 GOA
Cellular Component GO Annotation Evidence Reference Source
is active in endosome IDA
IDA: Inferred from direct assay
18222170 GOA
is active in endosome membrane IDA
IDA: Inferred from direct assay
18222170 GOA
is active in mitochondrion IDA
IDA: Inferred from direct assay
19898473 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRAF3 Protein Structure

zf-TRAF

zf-TRAF: TRAF-type zinc finger (136 - 192)

MATH

MATH: MATH domain (422 - 561)

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  • 568 a.a.
Protein Preferred Names Protein Names

TNF receptor-associated factor 3

CD40 associated protein 1

TRAF3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TRAF3 Q13114 CCDC184 Homo sapiens Q52MB2
Validated Y2H
32296183
Intra
TRAF3 Q13114 CCDC184 Homo sapiens Q52MB2
Y2H Array
32296183
Intra
TRAF3 Q13114 CCDC184 Homo sapiens Q52MB2
Y2H Prey Pooling
32296183
Intra
TRAF3 Q13114 UBE2I Homo sapiens Q7KZS0
Y2H Prey Pooling
32296183
Intra
TRAF3 Q13114 UBE2I Homo sapiens Q7KZS0
Validated Y2H
32296183
Intra
TRAF3 Q13114 UBE2I Homo sapiens Q7KZS0
Y2H Array
32296183
Intra
TRAF3 Q13114 PDZD4 Homo sapiens Q17RL8
Validated Y2H
32296183
Intra
TRAF3 Q13114 CCDC13 Homo sapiens Q8IYE1
Y2H Prey Pooling
32296183
Intra
TRAF3 Q13114 CCDC13 Homo sapiens Q8IYE1
Validated Y2H
32296183
Intra
TRAF3 Q13114 CCDC13 Homo sapiens Q8IYE1
Y2H Array
32296183
Intra
TRAF3 Q13114 ASCC1 Homo sapiens Q8N9N2-2
Validated Y2H
32296183
Intra
TRAF3 Q13114 IP6K3 Homo sapiens Q96PC2
Y2H Prey Pooling
32296183
Intra
TRAF3 Q13114 IP6K3 Homo sapiens Q96PC2
Validated Y2H
32296183
Intra
TRAF3 Q13114 IP6K3 Homo sapiens Q96PC2
Y2H Array
32296183
Intra
TRAF3 Q13114 POM121 Homo sapiens Q96HA1-2
Validated Y2H
32296183
Intra
TRAF3 Q13114 BIVM Homo sapiens Q86UB2
Y2H Prey Pooling
32296183
Intra
TRAF3 Q13114 BIVM Homo sapiens Q86UB2
Validated Y2H
32296183
Intra
TRAF3 Q13114 BIVM Homo sapiens Q86UB2
Y2H Array
32296183
Intra
TRAF3 Q13114 GMEB1 Homo sapiens Q9Y692
Y2H
32514408
Intra
TRAF3 Q13114 GMEB1 Homo sapiens Q9Y692
Pull Down
32514408
Intra
TRAF3 Q13114 RNF4 Homo sapiens P78317
Y2H Array
32296183
Intra
TRAF3 Q13114 RNF4 Homo sapiens P78317
Y2H Prey Pooling
32296183
Intra
TRAF3 Q13114 ZBTB49 Homo sapiens Q6ZSB9
Validated Y2H
32296183
Intra
TRAF3 Q13114 CDC37 Homo sapiens Q16543
Validated Y2H
32296183
Intra
TRAF3 Q13114 PIAS2 Homo sapiens O75928-2
Y2H Array
32296183
Intra
TRAF3 Q13114 PIAS2 Homo sapiens O75928-2
Y2H Prey Pooling
32296183
Intra
TRAF3 Q13114 TANK Homo sapiens Q92844
Anti Tag CoIP
34084167
Intra
TRAF3 Q13114 TANK Homo sapiens Q92844
TAP
14743216
Intra
TRAF3 Q13114 TANK Homo sapiens Q92844
X-Ray Diffraction
12005438
Intra
TRAF3 Q13114 TBK1 Homo sapiens Q9UHD2
Anti Tag CoIP
34084167
Intra
TRAF3 Q13114 TBK1 Homo sapiens Q9UHD2
Anti Tag CoIP
27135603
Intra
TRAF3 Q13114 SNAP29 Homo sapiens O95721
Y2H Array
32296183
Intra
TRAF3 Q13114 SNAP29 Homo sapiens O95721
Y2H Prey Pooling
32296183
Intra
TRAF3 Q13114 MAP3K14 Homo sapiens Q99558
TAP
14743216
Intra
TRAF3 Q13114 MAP3K14 Homo sapiens Q99558
Validated Y2H
32296183
Intra
TRAF3 Q13114 RIPK1 Homo sapiens Q13546
Validated Y2H
32296183
Intra
TRAF3 Q13114 RIPK1 Homo sapiens Q13546
Y2H
8612133
Intra
TRAF3 Q13114 RIPK2 Homo sapiens O43353
Anti Bait CoIP
23333941
Intra
TRAF3 Q13114 BRAF Homo sapiens P15056
Anti Bait CoIP
23153539
Intra
TRAF3 Q13114 CD40 Homo sapiens P25942
Y2H
7527023
Intra
TRAF3 Q13114 CD40 Homo sapiens P25942
Pull Down
7527023
Intra
TRAF3 Q13114 EDA2R Homo sapiens Q9HAV5
CoIP
15280356
Cross
TRAF3 Q13114 Zbp1 Mus musculus A2APF7
Anti Tag CoIP
21903422
Intra
TRAF3 Q13114 ZSCAN4 Homo sapiens Q8NAM6
Validated Y2H
32296183
Intra
TRAF3 Q13114 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra
TRAF3 Q13114 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Intra
TRAF3 Q13114 C10orf62 Homo sapiens Q5T681
Validated Y2H
32296183
Intra
TRAF3 Q13114 IFT25 Homo sapiens Q9Y547
Validated Y2H
32296183
Intra
TRAF3 Q13114 TRAF3IP1 Homo sapiens Q8TDR0
Anti Bait CoIP
10791955
Intra
TRAF3 Q13114 TRAF3IP1 Homo sapiens Q8TDR0
Pull Down
10791955
Intra
TRAF3 Q13114 GMEB2 Homo sapiens Q9UKD1
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Encephalopathy, Acute, Infection-Induced 5

Herpes Simplex Encephalitis, Susceptibility To, 3

IIAE5

Herpes Simplex Encephalitis 3

Encephalopathy, Acute, Infection-Induced , Susceptibility To, 5

Encephalopathy, Acute, Infection-Induced, 5, Herpes-Specific

Encephalopathy, Acute, Infection-Induced, 5

Hse3

Infection-Induced Acute Encephalopathy 5
Herpes Simplex Encephalitis

Hse

Hsv Encephalitis

Hsve

Herpes Simplex Meningo-Encephalitis

Herpes Simplex Neuroinvasion

Herpes Simplex Virus Encephalitis

Herpetic Encephalitis

Herpes Encephalitis

Herpes Simplex Virus 1 Encephalitis
Multisystem Inflammatory Syndrome In Children

Mis-C

Multisystem Inflammatory Disorder In Children And Adolescents

Paediatric Inflammatory Multisystemic Syndrome

Mic
Squamous Cell Carcinoma

Epidermoid Carcinoma

Squamous Cell Cancer

Carcinoma, Squamous Cell

Squamous Cell Skin Cancer

Malignant Squamous Cell Tumor

Squamous Carcinoma

Squamous Cell Epithelioma

Carcinoma Squamous Cell

Neoplasms, Squamous Cell

Squamous Cell Carcinoma - Category

Malignant Squamous Cell Neoplasm

Squamous Cell Carcinoma Of Skin
Ectodermal Dysplasia

Congenital Ectodermal Defect

Congenital Ectodermal Dysplasia

Ectodermal Dysplasia Syndrome

Dysplasia, Ectodermal
Lymphoma, Hodgkin, Classic

Hodgkin Lymphoma

Hodgkin Disease

Hodgkin'S Lymphoma

Hodgkins Lymphoma

Classic Hodgkin Lymphoma

CHL

Hodgkin Lymphoma, Susceptibility To

Hl

Hodgkin'S Sarcoma

Stage I Subdiaphragmatic Hodgkin Lymphoma

Stage Ii Subdiaphragmatic Hodgkin Lymphoma

Lymphoma, Hodgkin'S

Classic Hodgkin Disease

Hodgkin'S Disease

Lymphoma, Hodgkin, Susceptibility To

Hodgkin'S Disease Of Intrapelvic Lymph Nodes

Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb

Malignant Lymphogranuloma

Malignant Lymphogranulomatosis

Malignant Hodgkin Lymphoma

Classical Hodgkin Lymphoma, Type Not Specified
Anus Basaloid Carcinoma

Basaloid Carcinoma Of The Anus

Anal Basaloid Carcinoma
Spleen Cancer

Spleen Neoplasm

Splenic Neoplasm

Splenic Neoplasms

Malignant Splenic Tumor

Malignant Tumour Of Spleen

Tumor Of Spleen

Malignant Neoplasm Of Spleen
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Splenic Marginal Zone Lymphoma

Smzl

Splenic Marginal Zone B-Cell Lymphoma
Brooke-Spiegler Syndrome

Cyld Cutaneous Syndrome

Spiegler-Brooke Syndrome

Familial Cylindromatosis

BRSS

Bss

Sbs

Multiple Familial Trichoepithelioma

Ancell-Spiegler Cylindromas

Familial Multiple Trichoepithelioma

Trichoepithelioma

Fc

Mft

Multiple Familial Trichoepitheliomas

Ccs

Turban Tumor Syndrome

Schilbach-Rott Syndrome

Eccrine Dermal Cylindroma

Familial Multiple Trichoepitheliomata
Malaria

Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis

CM

Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever

Paludism

Cameroon Fever

Ague

Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever

Plasmodiosis

Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria
Lymphoma, Mucosa-Associated Lymphoid Type

Malt Lymphoma

Gastric Lymphoma, Primary

Lymphoma, Malt, Somatic

Mucosa-Associated Lymphoid Tissue Lymphoma

Extranodal Marginal Zone B-Cell Lymphoma

MALTOMA

Marginal Zone B-Cell Lymphoma

Mucosa-Associated Lymphatic Tissue Lymphoma

Primary Gastric Lymphoma

Gastric Lymphoma

Familial Primary Gastric Lymphoma
Myeloma, Multiple

Multiple Myeloma

Plasma Cell Myeloma

Kahler Disease

Myelomatosis

Medullary Plasmacytoma

Multiple Myeloma, Resistance To

Myeloma

Plasma Cell Dyscrasia

Kahler'S Disease

Multiple Myeloma, Susceptibility To

Myeloma - Multiple

Kahler-Bozzolo Disease

Plasma Cell Myelomas

MM

Plasma Cell Neoplasm

Primary Systemic Amyloidosis

Primary Amyloidosis

Immunoglobulin Deposition Disease

Plasmacytic Myeloma

Multiple Myelomata

Multiple Myeloma Nos

Multiple Myeloma Without Mention Of Remission

Monostotic Plasma Cell Myeloma

Mm - [Multiple Myeloma]
Noonan Syndrome 1

Noonan Syndrome

NS1

Male Turner Syndrome

Female Pseudo-Turner Syndrome

Turner Phenotype With Normal Karyotype

Noonan Syndrome With Pigmented Villonodular Synovitis

Turner'S Phenotype, Karyotype Normal

Familial Turner Syndrome

Noonan'S Syndrome

Noonan-Ehmke Syndrome

Ns

Pseudo-Ullrich-Turner Syndrome

Turner Syndrome In Female With X Chromosome

Turner-Like Syndrome

Ullrich-Noonan Syndrome

Noonan-Like/Multiple Giant Cell Lesion Syndrome

Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

Pterygium Colli Syndrome

Noonan Syndrome, Type 1

Turner Syndrome, Male
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-NP135 Oxidized low density lipoprotein (Human) / Unkown
HY-RS14969 TRAF3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS14970 TRAF3IP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS14971 TRAF3IP2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS14972 TRAF3IP3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TRAF3 MGD MGI:108041
Bos taurus TRAF3 VGNC VGNC:36272
Felis catus TRAF3 VGNC VGNC:66496
Macaca mulatta TRAF3 VGNC VGNC:78642
Canis familiaris TRAF3 VGNC VGNC:47764
Rattus norvegicus TRAF3 RGD RGD:1304633