Khdrbs1 - KH domain containing, RNA binding, signal transduction associated 1 Gene

Mus musculus

Also known as p62; p68; Sam68

Gene ID: 20218 | Gene type: protein coding

About Khdrbs1

Summary

Enables several functions, including identical protein binding activity; protein tyrosine kinase binding activity; and signaling adaptor activity. Involved in cell surface receptor signaling pathway and regulation of mRNA splicing, via spliceosome. Acts upstream of or within negative regulation of transcription by RNA polymerase II and regulation of RNA export from nucleus. Located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; future brain; and gonad. Orthologous to human KHDRBS1 (KH RNA binding domain containing, signal transduction associated 1). [provided by Alliance of Genome Resources, Apr 2022]

Khdrbs1 Products(1)

mRNA	Protein	Name
NM_011317.4	NP_035447.3	KH domain-containing, RNA-binding, signal transduction-associated protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	9315629	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	10077576	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10077576	MGI
enables protein tyrosine kinase binding	IPI IPI: Inferred from physical interaction	7799925	MGI
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	7799925	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell surface receptor signaling pathway	IDA IDA: Inferred from direct assay	7799925	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12496368	MGI
acts upstream of or within regulation of RNA export from nucleus	IDA IDA: Inferred from direct assay	12496368	MGI
involved in regulation of mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	22196734	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	12496368	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

KH domain-containing, RNA-binding, signal transduction-associated protein 1

GAP-associated tyrosine phosphoprotein p62	p21 Ras GTPase-activating protein-associated p62
src associated in mitosis, 68 kDa	src-associated in mitosis 68 kDa protein

Khdrbs1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Khdrbs1	Q60749	Crebbp	Mus musculus	P45481	Y2H	12496368
Intra	Khdrbs1	Q60749	Crebbp	Mus musculus	P45481	CoIP	12496368
Intra	Khdrbs1	Q60749	Fyn	Mus musculus	P39688	Pull Down	10077576
Intra	Khdrbs1	Q60749	Khdrbs1	Mus musculus	Q60749	Anti Tag CoIP	10077576
Cross	Khdrbs1	Q60749	Plcg1	Rattus norvegicus	P10686	Pull Down	10077576

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07237	KHDRBS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Khdrbs1	NCBI	NCBI:10657

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