Fyn - Fyn proto-oncogene Gene

Mus musculus

Gene ID: 14360 | Gene type: protein coding

About Fyn

Summary

Enables several functions, including cytoskeletal protein binding activity; protein tyrosine kinase activity; and transmembrane transporter binding activity. Involved in several processes, including negative regulation of dendritic spine maintenance; positive regulation of protein targeting to membrane; and positive regulation of tyrosine phosphorylation of STAT protein. Acts upstream of or within several processes, including cellular response to growth factor stimulus; nervous system development; and protein phosphorylation. Located in several cellular components, including Schaffer collateral - CA1 synapse; actin filament; and postsynaptic density. Is expressed in several structures, including alimentary system; central nervous system; cranial nerve; genitourinary system; and sensory organ. Used to study skin disease and skin squamous cell carcinoma. Human ortholog(s) of this gene implicated in Alzheimer's disease and schizophrenia. Orthologous to human Fyn (Fyn proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Fyn Products(3)

mRNA	Protein	Name
NM_001122892.1	NP_001116364.1	tyrosine-protein kinase Fyn isoform b
NM_001122893.1	NP_001116365.1	tyrosine-protein kinase Fyn isoform a
NM_008054.2	NP_032080.2	tyrosine-protein kinase Fyn isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled receptor binding	IPI IPI: Inferred from physical interaction	23169819	MGI
enables alpha-tubulin binding	IDA IDA: Inferred from direct assay	11826099	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	7730365	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	11826099	MGI
enables protein tyrosine kinase activity	EXP EXP: Inferred from Experiment	16709819	MGI
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	8175795	MGI
enables protein tyrosine kinase activity	IGI IGI: Inferred from genetic interaction	23169819	MGI
enables tau protein binding	IPI IPI: Inferred from physical interaction	11826099	MGI
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	12538589	MGI
enables tubulin binding	IDA IDA: Inferred from direct assay	11826099	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within activated T cell proliferation	IMP IMP: Inferred from mutant phenotype	1516132	MGI
acts upstream of or within cell surface receptor signaling pathway	IDA IDA: Inferred from direct assay	9177270	MGI
acts upstream of or within cellular response to platelet-derived growth factor stimulus	IDA IDA: Inferred from direct assay	17623777	MGI
acts upstream of or within cellular response to transforming growth factor beta stimulus	IGI IGI: Inferred from genetic interaction	21829547	MGI
acts upstream of or within dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	12372285	MGI
acts upstream of or within detection of mechanical stimulus involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	16190898	MGI
acts upstream of or within forebrain development	IGI IGI: Inferred from genetic interaction	16162939	MGI
acts upstream of or within forebrain development	IMP IMP: Inferred from mutant phenotype	15073522	MGI
acts upstream of or within gene expression	IGI IGI: Inferred from genetic interaction	31461442	MGI
involved in heart process	IGI IGI: Inferred from genetic interaction	27525436	MGI
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	1361685	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	1361685	MGI
involved in negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	10613822	MGI
involved in negative regulation of dendritic spine maintenance	IGI IGI: Inferred from genetic interaction	22820466	MGI
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20978343	MGI
acts upstream of or within negative regulation of protein catabolic process	IMP IMP: Inferred from mutant phenotype	16841086	MGI
acts upstream of or within negative regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	24627473	MGI
acts upstream of or within neuron migration	IGI IGI: Inferred from genetic interaction	16162939	MGI
acts upstream of or within neuron migration	IMP IMP: Inferred from mutant phenotype	15073522	MGI
acts upstream of neuron projection development	IGI IGI: Inferred from genetic interaction	18354028	MGI
acts upstream of or within peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	8175795	MGI
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	12681493	MGI
acts upstream of or within peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	9381182	MGI
involved in peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	27525436	MGI
acts upstream of or within positive regulation of neuron projection development	IGI IGI: Inferred from genetic interaction	18354028	MGI
acts upstream of or within positive regulation of protein localization to nucleus	IDA IDA: Inferred from direct assay	20142099	MGI
involved in positive regulation of protein localization to nucleus	IMP IMP: Inferred from mutant phenotype	20142099	MGI
involved in positive regulation of protein targeting to membrane	IGI IGI: Inferred from genetic interaction	22820466	MGI
involved in positive regulation of tyrosine phosphorylation of STAT protein	IMP IMP: Inferred from mutant phenotype	23438599	MGI
acts upstream of or within protein autophosphorylation	IDA IDA: Inferred from direct assay	8175795	MGI
acts upstream of protein catabolic process	IMP IMP: Inferred from mutant phenotype	16841086	MGI
acts upstream of or within protein phosphorylation	IMP IMP: Inferred from mutant phenotype	9892651	MGI
acts upstream of protein ubiquitination	IDA IDA: Inferred from direct assay	24627473	MGI
involved in reelin-mediated signaling pathway	IDA IDA: Inferred from direct assay	12526739	MGI
involved in regulation of calcium ion import across plasma membrane	IGI IGI: Inferred from genetic interaction	22820466	MGI
acts upstream of or within regulation of cell shape	IDA IDA: Inferred from direct assay	11826099	MGI
involved in regulation of glutamate receptor signaling pathway	IGI IGI: Inferred from genetic interaction	22820466	MGI
involved in regulation of peptidyl-tyrosine phosphorylation	IGI IGI: Inferred from genetic interaction	22820466	MGI
involved in response to amyloid-beta	IGI IGI: Inferred from genetic interaction	22820466	MGI
acts upstream of or within response to ethanol	IGI IGI: Inferred from genetic interaction	9381182	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	1361685	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	1361685	MGI
located in actin filament	IDA IDA: Inferred from direct assay	17623777	MGI
located in cell body	IDA IDA: Inferred from direct assay	11826099	MGI
located in cell periphery	IDA IDA: Inferred from direct assay	17623777	MGI
located in dendrite	IMP IMP: Inferred from mutant phenotype	20655099	MGI
located in endosome	IDA IDA: Inferred from direct assay	17623777	MGI
located in glial cell projection	IDA IDA: Inferred from direct assay	11826099	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	11826099	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	10557075	MGI
located in postsynaptic density	IMP IMP: Inferred from mutant phenotype	20655099	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tyrosine-protein kinase Fyn

Src Kinase p59	p59-Fyn
proto-oncogene c-Fyn	proto-oncogene tyrosine-protein kinase Fyn

Fyn Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Fyn	P39688	Pdgfrb	Mus musculus	P05622	Pull Down	7730365
Cross	Fyn	P39688	CBL	Homo sapiens	P22681	Pull Down	9890970
Cross	Fyn	P39688	CBL	Homo sapiens	P22681	Far-WB	9890970
Intra	Fyn	P39688	Khdrbs1	Mus musculus	Q60749	Y2H	15102471
Cross	Fyn	P39688	FZD2	Homo sapiens	Q14332	Pull Down	25417160
Intra	Fyn	P39688	Dynlt1	Mus musculus	P51807	Y2H	15102471
Intra	Fyn	P39688	Slamf1	Mus musculus	Q9QUM4	Anti Bait CoIP	12545173
Intra	Fyn	P39688	Slamf1	Mus musculus	Q9QUM4	Anti Tag CoIP	12545173
Intra	Fyn	P39688	Slamf1	Mus musculus	Q9QUM4	Pull Down	16847311
Intra	Fyn	P39688	Slamf1	Mus musculus	Q9QUM4	Anti Bait CoIP	11477403
Intra	Fyn	P39688	Khdrbs2	Mus musculus	Q9WU01	Pull Down	10077576
Intra	Fyn	P39688	Sphk2	Mus musculus	Q9JIA7	Anti Bait CoIP	16316995
Cross	Fyn	P39688	Irs1	Rattus norvegicus	P35570	Pull Down	8631859
Cross	Fyn	P39688	Irs1	Rattus norvegicus	P35570	Anti Bait CoIP	8631859

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120622	BMS-243117	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fyn	NCBI	NCBI:2534

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