DHRSX - dehydrogenase/reductase X-linked Gene

Homo sapiens

Also known as DHRSY; DHRS5X; DHRS5Y; DHRSXY; SDR7C6; CXorf11; SDR46C1

Gene ID: 207063 | Gene type: protein coding

About DHRSX

Cytogenetic location: Xp22.33 Genomic coordinates (GRCh38): X:2,219,506-2,500,976 (from NCBI)

This gene has 7 transcripts (splice variants), 164 orthologues and 4 paralogues. Ubiquitous expression in kidney (RPKM 6.0), liver (RPKM 5.1) and 25 other tissues.

Summary

Predicted to enable oxidoreductase activity. Involved in positive regulation of Autophagy. Located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

DHRSX Products(1)

mRNA	Protein	Name
NM_145177.3	NP_660160.2	dehydrogenase/reductase SDR family member on chromosome X

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of autophagy	IMP IMP: Inferred from mutant phenotype	25076851	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular region	IDA IDA: Inferred from direct assay	25076851	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DHRSX Protein Structure

adh_short

0
100
200
300
330 a.a.

Protein Preferred Names

Protein Names

dehydrogenase/reductase SDR family member on chromosome X

dehydrogenase/reductase (SDR family) X chromosome

DHRSX Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DHRSX	Q8N5I4	RETREG3	Homo sapiens	Q86VR2	Y2H Array	32296183
Intra	DHRSX	Q8N5I4	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
Intra	DHRSX	Q8N5I4	PGRMC2	Homo sapiens	O15173	Y2H Prey Pooling	32296183
Intra	DHRSX	Q8N5I4	PGRMC2	Homo sapiens	O15173	Y2H Array	32296183
Intra	DHRSX	Q8N5I4	HSD17B11	Homo sapiens	Q8NBQ5	Y2H Prey Pooling	32296183
Intra	DHRSX	Q8N5I4	HSD17B11	Homo sapiens	Q8NBQ5	Validated Y2H	32296183
Intra	DHRSX	Q8N5I4	HSD17B11	Homo sapiens	Q8NBQ5	Y2H Array	32296183
Intra	DHRSX	Q8N5I4	CMTM5	Homo sapiens	Q96DZ9-2	Validated Y2H	32296183
Intra	DHRSX	Q8N5I4	APOC1	Homo sapiens	P02654	Y2H Prey Pooling	32296183
Intra	DHRSX	Q8N5I4	APOC1	Homo sapiens	P02654	Y2H Array	32296183
Intra	DHRSX	Q8N5I4	ZDHHC15	Homo sapiens	Q96MV8	Y2H Prey Pooling	32296183
Intra	DHRSX	Q8N5I4	ZDHHC15	Homo sapiens	Q96MV8	Validated Y2H	32296183
Intra	DHRSX	Q8N5I4	ZDHHC15	Homo sapiens	Q96MV8	Y2H Array	32296183
Intra	DHRSX	Q8N5I4	TLCD4	Homo sapiens	Q96MV1	Validated Y2H	32296183
Intra	DHRSX	Q8N5I4	TLCD4	Homo sapiens	Q96MV1	Y2H Prey Pooling	32296183
Intra	DHRSX	Q8N5I4	TLCD4	Homo sapiens	Q96MV1	Y2H Array	32296183
Intra	DHRSX	Q8N5I4	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	DHRSX	Q8N5I4	TMEM143	Homo sapiens	Q96AN5	Y2H Prey Pooling	32296183
Intra	DHRSX	Q8N5I4	TMEM143	Homo sapiens	Q96AN5	Validated Y2H	32296183
Intra	DHRSX	Q8N5I4	TMEM143	Homo sapiens	Q96AN5	Y2H Array	32296183
Intra	DHRSX	Q8N5I4	FADS3	Homo sapiens	Q9Y5Q0	Y2H Array	32296183
Intra	DHRSX	Q8N5I4	FADS3	Homo sapiens	Q9Y5Q0	Y2H Prey Pooling	32296183
Intra	DHRSX	Q8N5I4	FADS3	Homo sapiens	Q9Y5Q0	Validated Y2H	32296183
Intra	DHRSX	Q8N5I4	PIGP	Homo sapiens	P57054	Y2H Prey Pooling	32296183
Intra	DHRSX	Q8N5I4	PIGP	Homo sapiens	P57054	Y2H Array	32296183
Intra	DHRSX	Q8N5I4	TMEM86B	Homo sapiens	Q8N661	Y2H Array	32296183
Intra	DHRSX	Q8N5I4	TMEM86B	Homo sapiens	Q8N661	Validated Y2H	32296183
Intra	DHRSX	Q8N5I4	TMEM86B	Homo sapiens	Q8N661	Y2H Prey Pooling	32296183
Intra	DHRSX	Q8N5I4	CIDEB	Homo sapiens	Q9UHD4	Validated Y2H	32296183
Intra	DHRSX	Q8N5I4	CIDEB	Homo sapiens	Q9UHD4	Y2H Prey Pooling	32296183
Intra	DHRSX	Q8N5I4	CIDEB	Homo sapiens	Q9UHD4	Y2H Array	32296183
Intra	DHRSX	Q8N5I4	ZBED1	Homo sapiens	O96006	Anti Tag CoIP	33961781
Intra	DHRSX	Q8N5I4	ZBED1	Homo sapiens	O96006	Anti Tag CoIP	28514442
Intra	DHRSX	Q8N5I4	RUSF1	Homo sapiens	Q96GQ5	Y2H Prey Pooling	32296183
Intra	DHRSX	Q8N5I4	RUSF1	Homo sapiens	Q96GQ5	Validated Y2H	32296183
Intra	DHRSX	Q8N5I4	RUSF1	Homo sapiens	Q96GQ5	Y2H Array	32296183
Intra	DHRSX	Q8N5I4	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	DHRSX	Q8N5I4	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	DHRSX	Q8N5I4	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Waisman Syndrome

Early-Onset Parkinsonism-Intellectual Disability Syndrome	Bgmr
Wsn	Laxova-Opitz Syndrome
WSMN	Parkinsonism, Early-Onset, With Mental Retardation
Basal Ganglion Disorder With Mental Retardation	Basal Ganglia Disorder With Intellectual Disability
Laxova Brown Hogan Syndrome	X-Linked Recessive Basal Ganglia Disorder With Intellectual Disability

Alpha-Thalassemia Myelodysplasia Syndrome

ATMDS	Acquired Hemoglobin H Disease
Alpha-Thalassemia Myelodysplasia Syndrome, Somatic	Acquired Hbh Disease
Alpha-Thalassemia-Myelodysplastic Syndrome	Hemoglobin H Disease, Acquired
Acquired Alpha-Thalassemia With Myelodysplastic Syndrome	Hemoglobin H Disease Acquired
Thalassemia, Alpha, Myelodysplasia Syndrome, Somatic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03746	DHRSX Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DHRSX	VGNC	VGNC:54133
Mus musculus	DHRSX	MGD	MGI:2181510
Rattus norvegicus	DHRSX	RGD	RGD:1305017

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