2. Gene
  3. Spp1 - secreted phosphoprotein 1 Gene

Spp1 - secreted phosphoprotein 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as OP; 2AR; Bsp; Eta; Opn; Ric; BNSP; BSPI; Opnl; Apl-1; ETA-1; Spp-1

Gene ID: 20750 | Gene type: protein coding

About Spp1

Summary

Enables extracellular matrix binding activity. Acts upstream of or within several processes, including cellular ion homeostasis; cellular response to leukemia inhibitory factor; and neutrophil chemotaxis. Located in apical part of cell and cytoplasm. Is expressed in several structures, including alimentary system; brain; metanephros; reproductive system; and skeleton. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; coronary artery disease (multiple); disease of cellular proliferation (multiple); and hepatitis. Orthologous to human SPP1 (secreted phosphoprotein 1). [provided by Alliance of Genome Resources, Apr 2022]

Spp1 Products(5)

mRNA Protein Name
NM_001204201.1 NP_001191130.1 osteopontin isoform 1
NM_001204202.1 NP_001191131.1 osteopontin isoform 2
NM_001204203.1 NP_001191132.1 osteopontin isoform 3 precursor
NM_001204233.1 NP_001191162.1 osteopontin isoform 4 precursor
NM_009263.3 NP_033289.2 osteopontin isoform 4 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables extracellular matrix binding IDA
IDA: Inferred from direct assay
18757743 MGI
enables integrin binding IDA
IDA: Inferred from direct assay
22654117 MGI
Biological Process GO Annotation Evidence Reference Source
involved in bone mineralization IDA
IDA: Inferred from direct assay
12817751 MGI
involved in bone mineralization IMP
IMP: Inferred from mutant phenotype
12817751 MGI
involved in calcium ion homeostasis IDA
IDA: Inferred from direct assay
12817751 MGI
acts upstream of or within cellular response to fluid shear stress IDA
IDA: Inferred from direct assay
24841674 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
acts upstream of or within collecting duct development IMP
IMP: Inferred from mutant phenotype
17898038 MGI
acts upstream of or within intracellular calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
17898038 MGI
acts upstream of or within intracellular chloride ion homeostasis IMP
IMP: Inferred from mutant phenotype
17898038 MGI
acts upstream of or within intracellular phosphate ion homeostasis IMP
IMP: Inferred from mutant phenotype
17898038 MGI
acts upstream of or within intracellular sodium ion homeostasis IMP
IMP: Inferred from mutant phenotype
17898038 MGI
acts upstream of or within neutrophil chemotaxis IDA
IDA: Inferred from direct assay
21321126 MGI
acts upstream of or within neutrophil chemotaxis IGI
IGI: Inferred from genetic interaction
21321126 MGI
acts upstream of or within positive regulation of cell-substrate adhesion IDA
IDA: Inferred from direct assay
18757743 MGI
acts upstream of or within urate biosynthetic process IMP
IMP: Inferred from mutant phenotype
17898038 MGI
Cellular Component GO Annotation Evidence Reference Source
located in apical part of cell IDA
IDA: Inferred from direct assay
16518820 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
16518820 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

osteopontin

44 kDa bone phosphoprotein

bone sialoprotein 1

calcium oxalate crystal growth inhibitor protein

early T-lymphocyte activation 1 protein

minopontin

osteopontin-like protein

Recombinant Spp1 Proteins

Cat. No. Product Name Accession Purity
HY-P71786 Osteopontin/OPN Protein, Mouse (P.pastoris, His) P10923 (L17-S290) ≥95%
HY-P78358 Osteopontin/OPN Protein, Mouse (HEK293, His) P10923 (L17-N294) ≥95%

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-108009A Rezafungin acetate Inhibitor 98.15% Unkown
HY-108009 Rezafungin Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-104029 Olorofim Inhibitor 99.57% Phase 2
Pre-clinical Phase
Bioactive Molecules (18)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B2060A Tiamulin fumarate Inhibitor ≥98.0% Unkown
HY-113491 3-Phosphoglyceric acid 99.78% Unkown
HY-B2060 Tiamulin Inhibitor 98.07% Unkown
HY-RS13702 SPP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS16219 SPP1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-126491 SPP-DM1 ≥95.0% Unkown
HY-N6695 Aflatoxicol ≥99.0% Unkown
HY-116479 Citromycetin / Unkown
HY-12613 2-C-methylene-myo-inositol oxide / Unkown
HY-136380S Clodinafop-propargyl-13C6 / Unkown
HY-139746 FPI-1602 Inhibitor / Unkown
HY-164207 VLPA-GlcNAc / Unkown
HY-N2340A D-(+)-Melezitose hydrate ≥98.0% Unkown
HY-N2728 6-O-Syringoylajugol / Unkown
HY-P0068 Aminocandin Inhibitor / Unkown
HY-120729 Pyrazophos Inhibitor / Unkown
HY-N11995 allo-Aloeresin D / Unkown
HY-N12882 (Z)-10-Hexadecen-1-ol / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spp1 NCBI NCBI:6696
Macaca fascicularis Spp1 NCBI NCBI:102137879
Rattus norvegicus Spp1 NCBI NCBI:25353