2. Gene
  3. SPP1 - Spp1 secreted phosphoprotein 1 Gene

SPP1 - Spp1 secreted phosphoprotein 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as OSP

Gene ID: 25353 | Gene type: protein coding

About SPP1

Summary

Predicted to enable extracellular matrix binding activity and Integrin binding activity. Involved in several processes, including negative regulation of collateral sprouting of intact axon in response to injury; osteoblast differentiation; and positive regulation of bone resorption. Located in several cellular components, including extracellular space; perinuclear region of cytoplasm; and vesicle. Used to study several diseases, including encephalomyelitis; myocarditis; radiculopathy; renovascular hypertension; and visual epilepsy. Biomarker of autosomal dominant polycystic kidney disease; calcinosis; and glomerulosclerosis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; coronary artery disease (multiple); disease of cellular proliferation (multiple); and hepatitis. Orthologous to human SPP1 (secreted phosphoprotein 1). [provided by Alliance of Genome Resources, Apr 2022]

SPP1 Products(1)

mRNA Protein Name
NM_012881.2 NP_037013.2 osteopontin precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in cell adhesion IDA
IDA: Inferred from direct assay
11792563 RGD
involved in cell adhesion IMP
IMP: Inferred from mutant phenotype
3024151 RGD
involved in cell differentiation IEP
IEP: Inferred from expression pattern
16618210 RGD
involved in negative regulation of collateral sprouting of intact axon in response to injury IEP
IEP: Inferred from expression pattern
15625076 RGD
involved in osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
15598896 RGD
involved in positive regulation of bone resorption IDA
IDA: Inferred from direct assay
11792563 RGD
involved in response to 2,3,7,8-tetrachlorodibenzodioxine IDA
IDA: Inferred from direct assay
16414014 RGD
involved in response to macrophage colony-stimulating factor IEP
IEP: Inferred from expression pattern
7669437 RGD
involved in response to steroid hormone IDA
IDA: Inferred from direct assay
11250650 RGD
Cellular Component GO Annotation Evidence Reference Source
located in cell projection IDA
IDA: Inferred from direct assay
12162503 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
18758911 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
12162503 RGD
located in vesicle IDA
IDA: Inferred from direct assay
18758911 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

osteopontin

SPP-1

Sialoprotein (osteopontin)

bone sialoprotein 1

osteopontin-like

Recombinant SPP1 Proteins

Cat. No. Product Name Accession Purity
HY-P79222 Osteopontin/OPN Protein, Rat (CHO, His) P08721 (L17-N317) ≥95%

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-108009A Rezafungin acetate Inhibitor 98.15% Yes
HY-108009 Rezafungin Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-104029 Olorofim Inhibitor 99.57% Phase 3
Pre-clinical Phase
Bioactive Molecules (21)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B2060A Tiamulin fumarate Inhibitor ≥98.0% Unkown
HY-113491 3-Phosphoglyceric acid 99.78% Unkown
HY-B2060 Tiamulin Inhibitor 98.07% Unkown
HY-RS13702 SPP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS16219 SPP1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-126491 SPP-DM1 ≥95.0% Unkown
HY-N6695 Aflatoxicol ≥99.0% Unkown
HY-136380 Clodinafop-propargyl ≥98.0% Unkown
HY-116479 Citromycetin Inhibitor / Unkown
HY-12613 2-C-methylene-myo-inositol oxide / Unkown
HY-136380S Clodinafop-propargyl-13C6 / Unkown
HY-139746 FPI-1602 Inhibitor / Unkown
HY-164207 VLPA-GlcNAc / Unkown
HY-N2340A D-(+)-Melezitose hydrate ≥98.0% Unkown
HY-N2728 6-O-Syringoylajugol / Unkown
HY-P0068 Aminocandin Inhibitor / Unkown
HY-120729 Pyrazophos Inhibitor / Unkown
HY-B2060S1 Tiamulin-d10-1 hydrochloride Inhibitor / Unkown
HY-N11995 allo-Aloeresin D / Unkown
HY-N12882 (Z)-10-Hexadecen-1-ol / Unkown
HY-N15183 Aselacin C / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990116 Anti-Mouse osteopontin/SPP1 Antibody (103D6) Inhibitor 95.00% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens SPP1 NCBI NCBI:6696
Macaca fascicularis SPP1 NCBI NCBI:102137879
Mus musculus SPP1 NCBI NCBI:20750