2. Gene
  3. ALCAM - activated leukocyte cell adhesion molecule Gene

ALCAM - activated leukocyte cell adhesion molecule Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MEMD; CD166

Gene ID: 214 | Gene type: protein coding

About ALCAM

Cytogenetic location: 3q13.11 Genomic coordinates (GRCh38): 3:105,366,909-105,576,900 (from NCBI)

This gene has 9 transcripts (splice variants), 258 orthologues and 3 paralogues. Broad expression in lung (RPKM 33.7), brain (RPKM 28.3) and 24 other tissues.

Summary

This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2011]

ALCAM Products(4)

mRNA Protein Name
NM_001243280.2 NP_001230209.1 CD166 antigen isoform 2 precursor
NM_001243281.2 NP_001230210.1 CD166 antigen isoform 3 precursor
NM_001243283.2 NP_001230212.1 CD166 antigen isoform 4 precursor
NM_001627.4 NP_001618.2 CD166 antigen isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
26146185 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
24945728 GOA
Biological Process GO Annotation Evidence Reference Source
involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP
IMP: Inferred from mutant phenotype
16352806 GOA
Cellular Component GO Annotation Evidence Reference Source
part of T cell receptor complex IDA
IDA: Inferred from direct assay
15294938 GOA
located in immunological synapse IDA
IDA: Inferred from direct assay
15294938 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
15294938 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALCAM Protein Structure

V-set

V-set: Immunoglobulin V-set domain (34 - 130)

C2-set_2

C2-set_2: CD80-like C2-set immunoglobulin domain (137 - 231)

Ig_2

Ig_2: Immunoglobulin domain (255 - 330)

Ig_2

Ig_2: Immunoglobulin domain (337 - 412)

Ig_3

Ig_3: Immunoglobulin domain (415 - 489)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 583 a.a.
Protein Preferred Names Protein Names

CD166 antigen

ALCAM Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra ALCAM Q13740 LGALS1 Homo sapiens P09382
Competition Binding
24945728
Intra ALCAM Q13740 LGALS1 Homo sapiens P09382
ELISA
24945728
Intra ALCAM Q13740 LGALS1 Homo sapiens P09382
Anti Tag CoIP
33961781
Intra ALCAM Q13740 LGALS3 Homo sapiens P17931
Pull Down
24945728
Intra ALCAM Q13740 LGALS3 Homo sapiens P17931
ELISA
24945728
Intra ALCAM Q13740 ALCAM Homo sapiens Q13740
GMS
26146185
Intra ALCAM Q13740 CD6 Homo sapiens P30203
Competition Binding
24945728
Intra ALCAM Q13740 CD6 Homo sapiens P30203
ELISA
24945728
Intra ALCAM Q13740 ALCAM Homo sapiens Q13740
Light Scattering
26146185
Intra ALCAM Q13740 ALCAM Homo sapiens Q13740
SLCA
26146185
Intra ALCAM Q13740 ABCC1 Homo sapiens P33527
Anti Tag CoIP
35271311
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ALCAM Proteins

Cat. No. Product Name Accession Purity
HY-P7471 ALCAM/CD166 Protein, Human (HEK293, Fc) Q13740 (W28-A526) ≥95%
HY-P78056 ALCAM/CD166 Protein, Human (Biotinylated, HEK293, His) Q13740 (W28-A526) ≥95%
HY-P78057 ALCAM/CD166 Protein, Human (Biotinylated, HEK293, His-Avi) Q13740 (W28-A526) ≥95%

Related Diseases

Diseases Alias
Stork Bite

Salmon Patch Nevus

Unna'S Nevus
Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00557 ALCAM Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99788 Praluzatamab Inhibitor 95.00% Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ALCAM MGD MGI:1313266
Canis familiaris ALCAM VGNC VGNC:37779
Rattus norvegicus ALCAM RGD RGD:619972
Bos taurus ALCAM VGNC VGNC:25805
Macaca mulatta ALCAM VGNC VGNC:69783
Felis catus ALCAM VGNC VGNC:59735
Macaca fascicularis ALCAM NCBI NCBI:101867493
Others ALCAM NCBI