F13A1 - coagulation factor XIII A chain Gene

Homo sapiens

Also known as F13A

Gene ID: 2162 | Gene type: protein coding

About F13A1

Cytogenetic location: 6p25.1 Genomic coordinates (GRCh38): 6:6,144,084-6,320,662 (from NCBI)

This gene has 6 transcripts (splice variants), 291 orthologues, 8 paralogues and is associated with 4 phenotypes. Biased expression in placenta (RPKM 246.8), urinary bladder (RPKM 65.1) and 12 other tissues.

Summary

This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by Thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active Enzyme, factor XIIIa, as platelet factor XIII. This Enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]

F13A1 Products(1)

mRNA	Protein	Name
NM_000129.4	NP_000120.2	coagulation factor XIII A chain

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA
enables protein-glutamine gamma-glutamyltransferase activity	IDA IDA: Inferred from direct assay	27363989	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in blood coagulation, fibrin clot formation	IDA IDA: Inferred from direct assay	27363989	GOA
involved in peptide cross-linking	IDA IDA: Inferred from direct assay	27363989	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

F13A1 Protein Structure

Transglut_N

Transglut_core

Transglut_C

0
200
400
600
732 a.a.

Protein Preferred Names

Protein Names

coagulation factor XIII A chain

FSF, A subunit

F13A1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	F13A1	P00488	WWOX	Homo sapiens	Q9NZC7-5	Validated Y2H	32814053
Intra	F13A1	P00488	WWOX	Homo sapiens	Q9NZC7-5	Y2H Array	32814053
Intra	F13A1	P00488	WWOX	Homo sapiens	Q9NZC7-5	Y2H Pooling	32814053
Intra	F13A1	P00488	IL16	Homo sapiens	Q14005-2	Y2H Array	32814053
Intra	F13A1	P00488	IL16	Homo sapiens	Q14005-2	Y2H Pooling	32814053
Intra	F13A1	P00488	IL16	Homo sapiens	Q14005-2	Validated Y2H	32814053
Intra	F13A1	P00488	CDCA4	Homo sapiens	Q9BXL8	Y2H Pooling	32814053
Intra	F13A1	P00488	CDCA4	Homo sapiens	Q9BXL8	Validated Y2H	32814053
Intra	F13A1	P00488	CDCA4	Homo sapiens	Q9BXL8	Y2H Array	32814053
Intra	F13A1	P00488	EGFL8	Homo sapiens	Q99944	Y2H Array	32814053
Intra	F13A1	P00488	KLHL20	Homo sapiens	Q9Y2M5	Validated Y2H	32814053
Intra	F13A1	P00488	KLHL20	Homo sapiens	Q9Y2M5	Y2H Pooling	32814053
Intra	F13A1	P00488	KLHL20	Homo sapiens	Q9Y2M5	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant F13A1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70226	Coagulation factor XIII A/F13A Protein, Human (HEK293, His)	AAH27963.1 (G39-M732)	≥95%

Related Diseases

Diseases

Alias

Factor Xiii, A Subunit, Deficiency Of

Factor Xiiia Deficiency	Factor Xiii Subunit A Deficiency
FA13AD	F13 Deficiency Type 2
Type Ii F13 Deficiency

Thrombophilia Due To Thrombin Defect

Venous Thromboembolism	Venous Thrombosis
Thrombophilia Due To Factor 2 Defect	Thromboembolism
THPH1	Thromboembolism, Susceptibility To
Venous Thromboembolism, Susceptibility To	Venous Thrombosis, Protection Against
Prothrombin-Related Thrombophilia	Hyperprothrombinemia
Venous Thrombosis, Susceptibility To	Thrombophilia 1 Due To Thrombin Defect
F2-Related Thrombophilia	Factor Ii-Related Thrombophilia
Prothrombin 20210g>A Thrombophilia	Prothrombin G20210a Thrombophilia
Prothrombin Thrombophilia

Factor Xiii Deficiency

Hereditary Factor Xiii Deficiency Disease	Deficiency, Laki-Lorand Factor
Congenital Factor Xiii Deficiency	Fibrin Stabilizing Factor Deficiency
Deficiency, Factor Xiii	Factor Xiii Deficiency Disease
Deficiency Of Factor Xiii	Fibrin-Stabilizing Factor Deficiency
Factor Xiii Deficiency, Congenital

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Cutaneous Fibrous Histiocytoma

Dermatofibroma	Fibrohistiocytic Tumor
Benign Cutaneous Fibrous Histiocytoma	Fibrous Histiocytoma Of Skin
Fibrous Xanthoma Of Skin	Pleomorphic Fibroma
Sclerosing Angioma	Sclerosing Angioma Of Skin
Fibrous Histiocytoma

Granuloma Annulare

Granulome Annulare

Ga - [Granuloma Annulare]

Fibrous Histiocytoma

Benign Fibrous Histiocytoma	Histiocytoma, Benign Fibrous
Fibroxanthoma	Histiocytoma Fibrous

Xanthoma Disseminatum

Montgomery Syndrome

Dermatofibrosarcoma Protuberans

DFSP	Dermatofibrosarcoma
Giant Cell Fibroblastoma	Metastatic Dermatofibrosarcoma Protuberans
Familial Dermatofibrosarcoma Protuberans	Darier-Ferrand Tumor
Darier-Hoffmann Tumor

Juvenile Xanthogranuloma

Multiple Eruptive Juvenile Xanthogranuloma	Naevoxanthoendothelioma
Xanthoma Neviforme	Xanthogranuloma, Juvenile

Thrombosis

Thrombosis Of Blood Vessel

Fibroma

Angiolipoma

Pulmonary Embolism

Pulmonary Artery Embolism	Pulmonary Embolus
Pulmonary Emboli

Neurofibroma

Neurofibromas	Neurofibromatoses
Nerve Sheath Tumors

Priapism

Mentulagra	Priapism, Familial Idiopathic
Familial Idiopathic Priapism	Pathologic Erection
Painful Erection

Malignant Fibrous Histiocytoma

Undifferentiated Pleomorphic Sarcoma	Ups
Histiocytoma, Malignant Fibrous	Fibroxanthosarcoma
Mfh	Malignant Fibrohistiocytic Tumors
Histiocytoma, Fibrous, Malignant

Langerhans Cell Histiocytosis

Histiocytosis X	Lch
Langerhans Cell Granulomatosis	Langerhans-Cell Histiocytosis
Letterer-Siwe Disease	Hashimoto-Pritzger Disease
Histiocytosis, Langerhans-Cell	Langerhan'S Cell Histiocytosis
Letterer-Siwe Disease Involving Intra-Abdominal Lymph Nodes	Letterer-Siwe Disease Involving Intrapelvic Lymph Nodes
Letterer-Siwe Disease Involving Intrathoracic Lymph Nodes	Letterer-Siwe Disease Involving Lymph Nodes Of Axilla And Upper Limb
Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face And Neck	Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face, And Neck
Letterer-Siwe Disease Involving Lymph Nodes Of Inguinal Region And Lower Limb	Letterer-Siwe Disease Involving Lymph Nodes Of Multiple Sites
Letterer-Siwe Disease Involving Spleen	Letterer-Siwe Disease Of Intra-Abdominal Lymph Nodes
Letterer-Siwe Disease Of Intrapelvic Lymph Nodes	Letterer-Siwe Disease Of Intrathoracic Lymph Nodes
Letterer-Siwe Disease Of Lymph Nodes Of Axilla And Upper Limb	Letterer-Siwe Disease Of Lymph Nodes Of Axilla And/Or Upper Limb
Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And Neck	Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And/Or Neck
Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region Amd/Or Lower Limb	Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And Lower Limb
Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb	Letterer-Siwe Disease Of Lymph Nodes Of Multiple Sites
Letterer-Siwe Disease Of Spleen	Familial Letterer-Siwe Disease
Langerhans-Cell Histiocytosis Nos

Thrombophilia

Hypercoagulability State

Dysfibrinogenemia, Congenital

Dysfibrinogenemia	Hypodysfibrinogenemia
Familial Dysfibrinogenemia	Familial Hypodysfibrinogenemia
Hypodysfibrinogenemia, Congenital	Dysfibrinogenemia, Familial
Congenital Dysfibrinogenemia	DYSFIBRIN

Hemangiopericytoma, Malignant

Hemangiopericytoma	Haemangiopericytic Meningioma
Malignant Hemangiopericytoma	Solitary Fibrous Tumor

Cerebrovascular Disease

Cerebrovascular Disorder	Cerebrovascular Accident
Cerebrovascular Disorders	Cva
Stroke

Hemorrhagic Disease

Hemorrhagic Disorders	Hemorrhagic Diathesis
Hemorrhagic Diseases	Bleeding Tendency
Acquired Coagulation Factor Inhibitor Disorder	Acquired Inhibitor Of Coagulation
Antithrombinaemia	Antithromboplastinogenaemia
Circulating Anticoagulant Disorder	Haemorrhagic Disorder Due To Antithrombinaemia
Haemorrhagic Disorder Due To Excess Administered Heparin	Antithromboplastinaemia
Haemorrhagic Disorder Due To Hyperheparinemia

Dedifferentiated Liposarcoma

Ddls	Liposarcoma Dedifferentiated
Liposarcoma, Dedifferentiated

Castleman Disease

Angiofollicular Ganglionic Hyperplasia	Angiofollicular Lymph Hyperplasia
Giant Lymph Node Hyperplasia	Castleman'S Disease
Angiofollicular Lymph Node Hyperplasia	Lymphoid Hamartoma
Benign Giant Lymphoma	Angiolymphoid Hyperplasia

Localized Scleroderma

Morphea	Localised Scleroderma
Localized Fibrosing Scleroderma	Circumscribed Scleroderma
Localised Morphea	Localised Morphoea
Localized Morphea	Scleroderma, Circumscribed Or Localised
Scleroderma, Circumscribed Or Localized	Scleroderma, Localized

Pancytopenia

Basal Cell Carcinoma

Basal Cell Cancer	Basal Cell Neoplasm
Basal Cell Carcinoma Of Skin	Malignant Basal Cell Tumor
Basal Cell Tumor	Epithelioma Basal Cell
Malignant Basal Cell Neoplasm	Rodent Ulcer
Carcinoma Basal Cell	Neoplasms, Basal Cell
Basal Cell Carcinomas	Experimental Organism Basal Cell Carcinoma
Nodulo-Ulcerative Basal Cell Carcinoma	Basalioma
Basal Cell Epithelioma Of Skin	Bcc - [Basal Cell Carcinoma] Of Skin
Rodent Ulcer Of Skin	Rodent Ulcer Of Unspecified Site
Basal Cell Epithelioma Of Unspecified Site

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04628	F13A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	F13A1	VGNC	VGNC:28680
Mus musculus	F13A1	MGD	MGI:1921395
Canis familiaris	F13A1	VGNC	VGNC:40545
Macaca mulatta	F13A1	VGNC	VGNC:72462
Rattus norvegicus	F13A1	RGD	RGD:621495
Felis catus	F13A1	VGNC	VGNC:62021
Others	F13A1	NCBI