KLHL20 - kelch like family member 20 Gene

Homo sapiens

Also known as KHLHX; KLEIP; KLHLX

Gene ID: 27252 | Gene type: protein coding

About KLHL20

Cytogenetic location: 1q25.1 Genomic coordinates (GRCh38): 1:173,714,981-173,786,692 (from NCBI)

This gene has 5 transcripts (splice variants), 207 orthologues and 54 paralogues. Ubiquitous expression in testis (RPKM 10.0), fat (RPKM 7.7) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 44-56 amino acid repeat motif. The kelch motif appears in many different polypeptide contexts and contains multiple potential protein-protein contact sites. Members of this family are present both throughout the cell and extracellularly, with diverse activities. [provided by RefSeq, Jul 2008]

KLHL20 Products(1)

mRNA	Protein	Name
NM_014458.4	NP_055273.2	kelch-like protein 20

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20389280	GOA
enables type II interferon binding	IDA IDA: Inferred from direct assay	20389280	GOA
contributes to ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	24768539	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	20389280	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi to endosome transport	IMP IMP: Inferred from mutant phenotype	24768539	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	20389280	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	20389280	GOA
involved in protein K33-linked ubiquitination	IDA IDA: Inferred from direct assay	24768539	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	20389280	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Cul3-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	20389280	GOA
located in PML body	IDA IDA: Inferred from direct assay	20389280	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	20389280	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	24768539	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLHL20 Protein Structure

BTB

BACK

Kelch_1

0
100
200
300
400
500
609 a.a.

Protein Preferred Names

Protein Names

kelch-like protein 20

Kelch motif containing protein

KLHL20 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KLHL20	Q9Y2M5	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	KLHL20	Q9Y2M5	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	KLHL20	Q9Y2M5	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	KLHL20	Q9Y2M5	MECP2	Homo sapiens	P51608	Y2H Pooling	32814053
Intra	KLHL20	Q9Y2M5	MECP2	Homo sapiens	P51608	Validated Y2H	32814053
Intra	KLHL20	Q9Y2M5	MECP2	Homo sapiens	P51608	Y2H Array	32814053
Intra	KLHL20	Q9Y2M5	ATN1	Homo sapiens	Q86V38	Validated Y2H	32814053
Intra	KLHL20	Q9Y2M5	ATN1	Homo sapiens	Q86V38	Y2H Pooling	32814053
Intra	KLHL20	Q9Y2M5	ATN1	Homo sapiens	Q86V38	Y2H Array	32814053
Intra	KLHL20	Q9Y2M5	GLE1	Homo sapiens	Q53GS7	Y2H Array	32814053
Intra	KLHL20	Q9Y2M5	GLE1	Homo sapiens	Q53GS7	Y2H Pooling	32814053
Intra	KLHL20	Q9Y2M5	GLE1	Homo sapiens	Q53GS7	Validated Y2H	32814053
Intra	KLHL20	Q9Y2M5	GIPC1	Homo sapiens	O14908-2	Y2H Array	32814053
Intra	KLHL20	Q9Y2M5	GIPC1	Homo sapiens	O14908-2	Validated Y2H	32814053
Intra	KLHL20	Q9Y2M5	GIPC1	Homo sapiens	O14908-2	Y2H Pooling	32814053
Intra	KLHL20	Q9Y2M5	PML	Homo sapiens	P29590	Pull Down	21840486
Intra	KLHL20	Q9Y2M5	PML	Homo sapiens	P29590	IF	20389280
Intra	KLHL20	Q9Y2M5	PML	Homo sapiens	P29590	Anti Tag CoIP	20389280
Intra	KLHL20	Q9Y2M5	PML	Homo sapiens	P29590	Anti Tag CoIP	25619834
Intra	KLHL20	Q9Y2M5	PML	Homo sapiens	P29590-1	Anti Tag CoIP	21840486
Intra	KLHL20	Q9Y2M5	PML	Homo sapiens	P29590-1	Pull Down	25619834
Intra	KLHL20	Q9Y2M5	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	KLHL20	Q9Y2M5	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	KLHL20	Q9Y2M5	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	KLHL20	Q9Y2M5	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	KLHL20	Q9Y2M5	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	KLHL20	Q9Y2M5	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	KLHL20	Q9Y2M5	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	KLHL20	Q9Y2M5	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	KLHL20	Q9Y2M5	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	KLHL20	Q9Y2M5	DAPK1	Homo sapiens	P53355	Anti Bait CoIP	20389280
Intra	KLHL20	Q9Y2M5	DAPK1	Homo sapiens	P53355	Anti Tag CoIP	20389280
Intra	KLHL20	Q9Y2M5	DAPK1	Homo sapiens	P53355	Anti Tag CoIP	25619834
Intra	KLHL20	Q9Y2M5	DAPK1	Homo sapiens	P53355	Pull Down	25619834
Intra	KLHL20	Q9Y2M5	CUL3	Homo sapiens	Q13618	Anti Tag CoIP	20389280
Intra	KLHL20	Q9Y2M5	CUL3	Homo sapiens	Q13618	Anti Tag CoIP	25619834
Intra	KLHL20	Q9Y2M5	CUL3	Homo sapiens	Q13618	Anti Tag CoIP	33961781
Intra	KLHL20	Q9Y2M5	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	KLHL20	Q9Y2M5	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	KLHL20	Q9Y2M5	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	KLHL20	Q9Y2M5	HTRA2	Homo sapiens	O43464	Y2H Pooling	32814053
Intra	KLHL20	Q9Y2M5	HTRA2	Homo sapiens	O43464	Validated Y2H	32814053
Intra	KLHL20	Q9Y2M5	HTRA2	Homo sapiens	O43464	Y2H Array	32814053
Intra	KLHL20	Q9Y2M5	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	KLHL20	Q9Y2M5	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	KLHL20	Q9Y2M5	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	KLHL20	Q9Y2M5	TTR	Homo sapiens	P02766	Y2H Pooling	32814053
Intra	KLHL20	Q9Y2M5	TTR	Homo sapiens	P02766	Validated Y2H	32814053
Intra	KLHL20	Q9Y2M5	TTR	Homo sapiens	P02766	Y2H Array	32814053
Intra	KLHL20	Q9Y2M5	NDUFV2	Homo sapiens	P19404	Validated Y2H	32814053
Intra	KLHL20	Q9Y2M5	NDUFV2	Homo sapiens	P19404	Y2H Array	32814053
Intra	KLHL20	Q9Y2M5	NDUFV2	Homo sapiens	P19404	Y2H Pooling	32814053
Intra	KLHL20	Q9Y2M5	IVNS1ABP	Homo sapiens	Q9Y6Y0	Pull Down	25619834
Intra	KLHL20	Q9Y2M5	IVNS1ABP	Homo sapiens	Q9Y6Y0	Anti Bait CoIP	25619834
Intra	KLHL20	Q9Y2M5	IVNS1ABP	Homo sapiens	Q9Y6Y0	Anti Tag CoIP	25619834
Intra	KLHL20	Q9Y2M5	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	KLHL20	Q9Y2M5	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	KLHL20	Q9Y2M5	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	KLHL20	Q9Y2M5	PHYH	Homo sapiens	O14832	Validated Y2H	32814053
Intra	KLHL20	Q9Y2M5	PHYH	Homo sapiens	O14832	Y2H Array	32814053
Intra	KLHL20	Q9Y2M5	PHYH	Homo sapiens	O14832	Y2H Pooling	32814053
Intra	KLHL20	Q9Y2M5	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	KLHL20	Q9Y2M5	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	KLHL20	Q9Y2M5	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	KLHL20	Q9Y2M5	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
Intra	KLHL20	Q9Y2M5	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
Intra	KLHL20	Q9Y2M5	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
Intra	KLHL20	Q9Y2M5	DBH	Homo sapiens	P09172	Validated Y2H	32814053
Intra	KLHL20	Q9Y2M5	DBH	Homo sapiens	P09172	Y2H Array	32814053
Intra	KLHL20	Q9Y2M5	DBH	Homo sapiens	P09172	Y2H Pooling	32814053
Intra	KLHL20	Q9Y2M5	PRMT6	Homo sapiens	Q96LA8	Y2H	23455924
Intra	KLHL20	Q9Y2M5	PRMT6	Homo sapiens	Q96LA8	Anti Tag CoIP	23455924

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Anterior Segment Dysgenesis 5

Anterior Segment Dysgenesis 5, Multiple Subtypes	ASGD5
Dysgenesis, Anterior Segment, Type 5, Multiple Subtypes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07362	KLHL20 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	KLHL20	VGNC	VGNC:30649
Macaca mulatta	KLHL20	VGNC	VGNC:74120
Felis catus	KLHL20	VGNC	VGNC:81199
Mus musculus	KLHL20	MGD	MGI:2444855
Canis familiaris	KLHL20	VGNC	VGNC:42455
Rattus norvegicus	KLHL20	RGD	RGD:1309490

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