CDCA4 - cell division cycle associated 4 Gene

Homo sapiens

Also known as HEPP; SEI-3/HEPP

Gene ID: 55038 | Gene type: protein coding

About CDCA4

Cytogenetic location: 14q32.33 Genomic coordinates (GRCh38): 14:105,009,573-105,021,083 (from NCBI)

This gene has 2 transcripts (splice variants), 199 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 19.7), placenta (RPKM 6.5) and 19 other tissues.

Summary

This gene encodes a protein that belongs to the E2F family of transcription factors. This protein regulates E2F-dependent transcriptional activation and cell proliferation, mainly through the E2F/retinoblastoma protein pathway. It also functions in the regulation of JUN oncogene expression. This protein shows distinctive nuclear-mitotic apparatus distribution, it is involved in spindle organization from prometaphase, and may also play a role as a midzone factor involved in chromosome segregation or cytokinesis. Two alternatively spliced transcript variants encoding the same protein have been noted for this gene. Two pseudogenes have also been identified on chromosome 1. [provided by RefSeq, May 2014]

CDCA4 Products(2)

mRNA	Protein	Name
NM_017955.4	NP_060425.2	cell division cycle-associated protein 4
NM_145701.4	NP_663747.1	cell division cycle-associated protein 4

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23455924	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDCA4 Protein Structure

SERTA

0
100
200
241 a.a.

Protein Preferred Names

Protein Names

cell division cycle-associated protein 4

hematopoietic progenitor protein

CDCA4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CDCA4	Q9BXL8	PARD6B	Homo sapiens	Q9BYG5	Validated Y2H	32296183
Intra	CDCA4	Q9BXL8	SUV39H1	Homo sapiens	O43463	Y2H	23455924
Intra	CDCA4	Q9BXL8	SUV39H1	Homo sapiens	O43463	Anti Tag CoIP	23455924
Intra	CDCA4	Q9BXL8	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	CDCA4	Q9BXL8	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	CDCA4	Q9BXL8	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	CDCA4	Q9BXL8	KDM1A	Homo sapiens	O60341	Anti Tag CoIP	23455924
Intra	CDCA4	Q9BXL8	KDM1A	Homo sapiens	O60341	Y2H	23455924
Intra	CDCA4	Q9BXL8	SUV39H2	Homo sapiens	Q9H5I1	Anti Tag CoIP	23455924
Intra	CDCA4	Q9BXL8	SUV39H2	Homo sapiens	Q9H5I1	Y2H	23455924
Intra	CDCA4	Q9BXL8	KLHL42	Homo sapiens	Q9P2K6	Validated Y2H	32296183
Intra	CDCA4	Q9BXL8	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
Intra	CDCA4	Q9BXL8	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	32296183
Intra	CDCA4	Q9BXL8	PRMT6	Homo sapiens	Q96LA8	Anti Tag CoIP	23455924

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Short-Rib Thoracic Dysplasia 4 With Or Without Polydactyly

Asphyxiating Thoracic Dystrophy 4	SRTD4
Atd4	Jatd
Jeune Asphyxiating Thoracic Dystrophy	Jeune Syndrome 4

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02313	CDCA4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CDCA4	VGNC	VGNC:27085
Macaca mulatta	CDCA4	VGNC	VGNC:70712
Felis catus	CDCA4	VGNC	VGNC:81001
Rattus norvegicus	CDCA4	RGD	RGD:1563593
Canis familiaris	CDCA4	VGNC	VGNC:39014
Mus musculus	CDCA4	MGD	MGI:1919213

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