Tgfb1i1 - transforming growth factor beta 1 induced transcript 1 Gene

Mus musculus

Also known as Hic5; ARA55; TSC-5; hic-5

Gene ID: 21804 | Gene type: protein coding

About Tgfb1i1

Summary

Predicted to enable several functions, including I-SMAD binding activity; Roundabout binding activity; and Androgen Receptor binding activity. Acts upstream of or within several processes, including epithelial cell differentiation; morphogenesis of embryonic epithelium; and negative regulation of fat cell differentiation. Located in focal adhesion. Is expressed in several structures, including bronchus; central nervous system; genitourinary system; heart; and vertebral axis musculature. Orthologous to human TGFB1I1 (transforming growth factor beta 1 induced transcript 1). [provided by Alliance of Genome Resources, Apr 2022]

Tgfb1i1 Products(4)

mRNA	Protein	Name
NM_001289550.1	NP_001276479.1	transforming growth factor beta-1-induced transcript 1 protein isoform a
NM_001289551.1	NP_001276480.1	transforming growth factor beta-1-induced transcript 1 protein isoform b
NM_001289552.1	NP_001276481.1	transforming growth factor beta-1-induced transcript 1 protein isoform c
NM_001289553.1	NP_001276482.1	transforming growth factor beta-1-induced transcript 1 protein isoform d

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9756887	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cell fate commitment	IGI IGI: Inferred from genetic interaction	15687259	MGI
acts upstream of or within epithelial cell differentiation	IGI IGI: Inferred from genetic interaction	15687259	MGI
acts upstream of fat cell differentiation	IGI IGI: Inferred from genetic interaction	15687259	MGI
acts upstream of or within morphogenesis of embryonic epithelium	IMP IMP: Inferred from mutant phenotype	15687259	MGI
acts upstream of or within negative regulation of fat cell differentiation	IGI IGI: Inferred from genetic interaction	15687259	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in focal adhesion	IDA IDA: Inferred from direct assay	11784865	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transforming growth factor beta-1-induced transcript 1 protein

TGF beta-stimulated clone 5	androgen receptor-associated protein of 55 kDa
hydrogen peroxide-inducible clone 5 protein

Tgfb1i1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Tgfb1i1	Q62219	Plekhh2	Mus musculus	Q8C115	Y2H	22832517
Cross	Tgfb1i1	Q62219	PTK2	Homo sapiens	Q05397	Pull Down	9756887

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14438	TGFB1I1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tgfb1i1	NCBI	NCBI:7041

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