1. Gene
  2. FANCG - FA complementation group G Gene

FANCG - FA complementation group G Gene

Homo sapiens

Also known as FAG; XRCC9

Gene ID: 2189 | Gene type: protein coding

About FANCG

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:35,073,839-35,079,942 (from NCBI)

This gene has 22 transcripts (splice variants), 185 orthologues and is associated with 62 phenotypes. Ubiquitous expression in bone marrow (RPKM 5.8), testis (RPKM 5.2) and 25 other tissues.

Summary

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group G. [provided by RefSeq, Jul 2008]

FANCG Products(1)

mRNA Protein Name
NM_004629.2 NP_004620.1 Fanconi anemia group G protein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
10627486 GOA
Biological Process GO Annotation Evidence Reference Source
involved in mitochondrion organization IMP
IMP: Inferred from mutant phenotype
17060495 GOA
Cellular Component GO Annotation Evidence Reference Source
part of Fanconi anaemia nuclear complex IDA
IDA: Inferred from direct assay
20347428 GOA
located in chromatin IDA
IDA: Inferred from direct assay
22343915 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
17060495 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FANCG Protein Structure

TPR_1

TPR_1: Tetratricopeptide repeat (247 - 274)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 622 a.a.
Protein Preferred Names Protein Names

Fanconi anemia group G protein

DNA repair protein XRCC9

FANCG Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
FANCG O15287 CCHCR1 Homo sapiens Q8TD31-3
Validated Y2H
32296183
Intra
FANCG O15287 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
Intra
FANCG O15287 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
Intra
FANCG O15287 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
Intra
FANCG O15287 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra
FANCG O15287 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra
FANCG O15287 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra
FANCG O15287 DMWD Homo sapiens G5E9A7
Y2H Pooling
32814053
Intra
FANCG O15287 DMWD Homo sapiens G5E9A7
Validated Y2H
32814053
Intra
FANCG O15287 DMWD Homo sapiens G5E9A7
Y2H Array
32814053
Intra
FANCG O15287 TCEANC Homo sapiens Q8N8B7-2
Validated Y2H
32296183
Intra
FANCG O15287 TPRX1 Homo sapiens Q8N7U7-2
Validated Y2H
32296183
Intra
FANCG O15287 GLE1 Homo sapiens Q53GS7
Validated Y2H
32814053
Intra
FANCG O15287 GLE1 Homo sapiens Q53GS7
Y2H Pooling
32814053
Intra
FANCG O15287 GLE1 Homo sapiens Q53GS7
Y2H Array
32814053
Intra
FANCG O15287 APBB2 Homo sapiens Q92870-2
Validated Y2H
32814053
Intra
FANCG O15287 APBB2 Homo sapiens Q92870-2
Y2H Array
32814053
Intra
FANCG O15287 APBB2 Homo sapiens Q92870-2
Y2H Pooling
32814053
Intra
FANCG O15287 PRPF18 Homo sapiens Q99633
Validated Y2H
32296183
Intra
FANCG O15287 SPTAN1 Homo sapiens Q13813
Anti Bait CoIP
19102630
Intra
FANCG O15287 SPTAN1 Homo sapiens Q13813
Y2H
19102630
Intra
FANCG O15287 HSPB1 Homo sapiens P04792
Validated Y2H
32814053
Intra
FANCG O15287 HSPB1 Homo sapiens P04792
Y2H Array
32814053
Intra
FANCG O15287 HSPB1 Homo sapiens P04792
Y2H Pooling
32814053
Intra
FANCG O15287 VIM Homo sapiens P08670
Validated Y2H
32814053
Intra
FANCG O15287 VIM Homo sapiens P08670
Y2H Pooling
32814053
Intra
FANCG O15287 VIM Homo sapiens P08670
Y2H Array
32814053
Intra
FANCG O15287 SUOX Homo sapiens P51687
Validated Y2H
32296183
Intra
FANCG O15287 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
FANCG O15287 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
FANCG O15287 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
FANCG O15287 NDUFV2 Homo sapiens P19404
Validated Y2H
32814053
Intra
FANCG O15287 NDUFV2 Homo sapiens P19404
Y2H Array
32814053
Intra
FANCG O15287 NDUFV2 Homo sapiens P19404
Y2H Pooling
32814053
Intra
FANCG O15287 PECAM1 Homo sapiens P16284
Validated Y2H
32814053
Intra
FANCG O15287 PECAM1 Homo sapiens P16284
Y2H Array
32814053
Intra
FANCG O15287 PECAM1 Homo sapiens P16284
Y2H Pooling
32814053
Intra
FANCG O15287 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
FANCG O15287 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
FANCG O15287 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
FANCG O15287 ZNF329 Homo sapiens Q86UD4
Validated Y2H
32296183
Intra
FANCG O15287 GFAP Homo sapiens P14136
Validated Y2H
32814053
Intra
FANCG O15287 GFAP Homo sapiens P14136
Y2H Array
32814053
Intra
FANCG O15287 GFAP Homo sapiens P14136
Y2H Pooling
32814053
Intra
FANCG O15287 PRPS1 Homo sapiens P60891
Validated Y2H
32814053
Intra
FANCG O15287 PRPS1 Homo sapiens P60891
Y2H Array
32814053
Intra
FANCG O15287 PRPS1 Homo sapiens P60891
Y2H Pooling
32814053
Intra
FANCG O15287 FANCA Homo sapiens O15360
Anti Tag CoIP
33961781
Intra
FANCG O15287 FANCA Homo sapiens O15360
Lumier
37398436
Intra
FANCG O15287 FANCA Homo sapiens O15360
CoIP
11063725
Intra
FANCG O15287 FANCA Homo sapiens O15360
Anti Tag CoIP
28514442
Intra
FANCG O15287 FANCA Homo sapiens O15360
Y2H
12649160
Intra
FANCG O15287 FANCA Homo sapiens O15360
BRET
37398436
Intra
FANCG O15287 FANCF Homo sapiens Q9NPI8
Y2H
12649160
Intra
FANCG O15287 FANCF Homo sapiens Q9NPI8
CoIP
11063725
Intra
FANCG O15287 ATXN3 Homo sapiens P54252
Y2H Array
32814053
Intra
FANCG O15287 ATXN3 Homo sapiens P54252
Y2H Pooling
32814053
Intra
FANCG O15287 ATXN3 Homo sapiens P54252
Validated Y2H
32814053
Cross
FANCG O15287 tax Human T-cell leukemia virus 1 P14079
MAPPIT
22458338
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Fanconi Anemia, Complementation Group G

Fanconi Anemia Complementation Group G

FANCG

Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia

Fanconi Anemia, Complementation Group L

Fanconi Anemia Complementation Group L

FANCL

Pituitary Stalk Interruption Syndrome

Ectopic Neurohypophysis

Psis

Fanconi Anemia, Complementation Group E

Fanconi Anemia Complementation Group E

FANCE

Face

Faces Syndrome

Fanconi Anemia, Complementation Group F

Fanconi Anemia Complementation Group F

FANCF

Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Fanconi Anemia, Complementation Group D1

Fanconi Anemia Complementation Group D1

FANCD1

Fad1

Inherited Cancer-Predisposing Syndrome Due To Biallelic Brca2 Mutations

Fanconi Anemia, Complementation Group B

Fanconi Anemia Complementation Group B

FANCB

Facb

Fa2

Fanconi Pancytopenia Type 2

Fanconi Pancytopenia, Type 2

Pancytopenia
Fanconi Anemia, Complementation Group U

Fanconi Anemia Complementation Group U

FANCU

Bloom Syndrome

BLM

Bs

Bls

Bloom-Torre-Machacek Syndrome

Microcephaly, Growth Restriction, And Increased Sister Chromatid Exchange 1

Mgrisce1

Congenital Telangiectatic Erythema

Congenital Telangiectatic Erythema Syndrome

Growth Deficiency, Sun-Sensitive, Telangiectatic, Hypo And Hyperpigmented Skin, Predisposition To Malignancy And Chromosomal Instability

Bloom'S Syndrome

Bsyn

Deficiency Anemia

Anemia

Deficiency Anemias

Anaemia

Fanconi Anemia, Complementation Group T

Fanconi Anemia Complementation Group T

FANCT

Peliosis Hepatis

Hepatic Peliosis

Telangiectasis Of Liver

Angiomatosis Of Liver

Ph - [Peliosis Hepatis]

Hepatic Angiomatosis

Physical Disorder

Physical Illness

Fanconi Anemia, Complementation Group D2

Fanconi Anemia Complementation Group D2

FANCD2

Fad2

Fa4

Fancd

Fanconi Pancytopenia Type 4

Fanconi Anemia, Complementation Group D

Fanconi Pancytopenia, Type 4

Facd

Fanconi Anemia Complementation Group D

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum

XPV

Xeroderma Pigmentosum Variant Type

Xeroderma Pigmentosum With Normal Dna Repair Rates

Photosensitivity With Defective Dna Synthesis

Xp

De Sanctis-Cacchione Syndrome

Desanctis-Cacchione Syndrome

Xeroderma Pigmentosa

Xerodermic Idiocy

Xeroderma Pigmentosum Variant

Xp - [Xeroderma Pigmentosum]

Atrophoderma Pigmentosum

Aplastic Anemia

Aplastic Anemia, Susceptibility To

Anemia Aplastic

Idiopathic Aplastic Anemia

Secondary Aplastic Anemia

Idiopathic Bone Marrow Failure

Aplastic Anemia Idiopathic

AA

Anemia, Aplastic

Aplastic Anemia, Idiopathic

Erythroid Aplasia

Aa - [Aplastic Anaemia]

Haematopoietic Aplasia

Aleukia Haemorrhagica

Anaemia Due To Decreased Red Cell Production

Aplasia Bone Marrow

Aplastic Bone Marrow

Hypoplastic Anaemia Nos

Myeloid Bone Marrow Aplasia

Pancytopenia

Panhaematopenia

Hypoproliferative Anaemia

Medullary Hypoplasia

Red Blood Cells Hypoplastic Anaemia

Panmyelophthisis

Panhemocytopenia

Refractive Hypoproliferative Anaemia

Toxic Anaemia

Toxic Aplastic Anaemia

Aplastic Anaemia Due To Toxic Cause

Idiopathic Aplastic Anaemia Nos

Squamous Cell Carcinoma, Head And Neck

Squamous Cell Carcinoma Of The Head And Neck

HNSCC

Head And Neck Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Lip

Squamous Cell Carcinoma, Head And Neck, Somatic

Carcinoma Of The Head And Neck

Squamous Cell Carcinomas Of Head And Neck

Scchn

Squamous Cell Carcinoma Of The Hypopharynx

Squamous Cell Carcinoma Of The Oropharynx

Squamous Cell Carcinoma Of Salivary Glands

Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses

Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses

Squamous Cell Carcinoma Of The Oral Cavity

Squamous Cell Carcinoma Of The Lip

Carcinoma, Squamous Cell Of Head And Neck

Lip Squamous Cell Carcinoma

Carcinoma, Squamous Cell, Head And Neck

Salivary Gland Squamous Cell Carcinoma

Cancer Of Head And Neck

Squamous Cell Carcinoma Of Oropharynx Nos

Shwachman-Diamond Syndrome 1

Shwachman-Diamond Syndrome

Shwachman Syndrome

Shwachman-Bodian-Diamond Syndrome

Sds

Pancreatic Insufficiency And Bone Marrow Dysfunction

Shwachman-Bodian Syndrome

SDS1

Lipomatosis Of Pancreas, Congenital

Congenital Lipomatosis Of Pancreas

Shwachman-Diamond Type Metaphyseal Dysplasia

Metaphyseal Chondrodysplasia, Shwachman Type

Shwachman-Diamond-Oski Syndrome

Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome

Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer

Breast And/Or Ovarian Cancer

Breast And Ovarian Cancer Syndrome

Hboc Syndrome

Hereditary Breast And Ovarian Cancer

Brca1- Brca2-Associated Hboc

Dyskeratosis Congenita

Dyskeratosis Congenita Autosomal Dominant

Dc

Dkc

Zinsser-Engman-Cole Syndrome

Dyskeratosis Congenita, Autosomal Dominant

Autosomal Dominant Dyskeratosis Congenita

Dkca

Dyskeratosis Congenita Scoggins Type

Zinsser-Cole-Engman Syndrome

X-Linked Dyskeratosis Congenita

Hoyeraal-Hreidarsson Syndrome

Seckel Syndrome

Microcephalic Primordial Dwarfism

Bird-Headed Dwarfism

Harper'S Syndrome

Virchow-Seckel Dwarfism

Nanocephalic Dwarfism

Sckl

Seckel-Type Dwarfism

Lynch Syndrome

Hereditary Nonpolyposis Colon Cancer

Hereditary Nonpolyposis Colorectal Cancer

Hereditary Nonpolyposis Colorectal Carcinoma

Hereditary Nonpolyposis Colorectal Neoplasms

Familial Nonpolyposis Colon Cancer

Hnpcc

Coca 1

Hereditary Defective Mismatch Repair Syndrome

Hereditary Non-Polyposis Colon Cancer

Hereditary Non-Polyposis Colon Cancer Syndrome

Hereditary Non-Polyposis Colorectal Cancer

Hereditary Non-Polyposis Colorectal Cancer Syndrome

Hereditary Nonpolyposis Colon Cancer Syndrome

Hereditary Nonpolyposis Colorectal Cancer Syndrome

Hereditary Nonpolyposis Colorectal Neoplasm

Hnpcc - Hereditary Nonpolyposis Colon Cancer

Cancer Family Syndrome

Familial Nonpolyposis Colorectal Cancer

Colon Cancer, Familial Nonpolyposis

Colorectal Neoplasms, Hereditary Nonpolyposis

Cancer, Colorectal, Nonpolyposis, Hereditary

Colorectal Cancer, Hereditary Nonpolyposis, Type 1

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia

Aase Syndrome

Erythrogenesis Imperfecta

Anemia, Diamond-Blackfan

Congenital Hypoplastic Anemia

Aase-Smith Ii Syndrome

Bds

Blackfan-Diamond Anemia

Congenital Prca

Congenital Hypoplastic Anemia, Blackfan-Diamond Type

Dba

Blackfan - Diamond Syndrome

Chronic Constitutional Pure Red Cell Anaemia

Anemia Diamond Blackfan Type

Anemia Congenital Erythroid Hypoplastic

Aregenerative Anemia Chronic Congenital

Blackfan Diamond Syndrome

Red Cell Aplasia, Pure Hereditary

Aase-Smith Syndrome Ii

Bda

Blackfan Diamond Anemia

Blackfan-Diamond Disease

Blackfan-Diamond Syndrome

Chronic Congenital Agenerative Anemia

Congenital Erythroid Hypoplastic Anemia

Congenital Hypoplastic Anemia Of Blackfan And Diamond

Congenital Pure Red Cell Anemia

Hypoplastic Congenital Anemia

Inherited Erythroblastopenia

Pure Hereditary Red Cell Aplasia

Anemia, Hypoplastic, Congenital

Anemia Hypoplastic Congenital

Fanconi Anemia

Constitutional Aplastic Anemia

Diamond-Blackfan Anemia 1

Aase Smith Syndrome 2

Congenital Red Cell Aplasia

Red Cell Aplasia Of Infants

Pure Red Cell Aplasia Of Infants

Congenital Red Cell Aplastic Anaemia

Congenital Pure Red Cell Anaemia

Congenital Erythroid Hypoplasia

Pearson Marrow-Pancreas Syndrome

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta FANCG VGNC VGNC:72612
Felis catus FANCG VGNC VGNC:102925
Canis familiaris FANCG VGNC VGNC:40722
Mus musculus FANCG MGD MGI:1926471
Rattus norvegicus FANCG RGD RGD:1587477
Bos taurus FANCG VGNC VGNC:28858