Tnks - tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase Gene

Mus musculus

Also known as ARTD5; TANK1; mTNKS1; 4930554K12Rik; D130072O21Rik

Gene ID: 21951 | Gene type: protein coding

About Tnks

Chromosome 8: 35,293,614-35,432,844 reverse strand.GRCm39:CM001001.3

This gene has 6 transcripts (splice variants), 279 orthologues, 2 paralogues and is associated with 58 phenotypes. Ubiquitous expression in testis adult (RPKM 23.3), whole brain E14.5 (RPKM 14.7) and 28 other tissues.

Summary

Predicted to enable histone binding activity; pentosyltransferase activity; and zinc ion binding activity. Predicted to be involved in several processes, including negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric; protein ADP-ribosylation; and regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of or within peptidyl-serine phosphorylation and peptidyl-threonine phosphorylation. Located in cytosol. Is expressed in central nervous system; dorsal root ganglion; and neural retina. Orthologous to human TNKS (tankyrase). [provided by Alliance of Genome Resources, Apr 2022]

Tnks Products(1)

mRNA	Protein	Name
NM_175091.3	NP_780300.2	poly [ADP-ribose] polymerase tankyrase-1

Tnks Protein Structure

PTZ00322

ANK

PHA02876

ANK

PHA03095

ANK

SAM_tankyrase1,2

tankyrase_like

0
300
600
900
1200
1320 a.a.

Protein Preferred Names

Protein Names

poly [ADP-ribose] polymerase tankyrase-1

ADP-ribosyltransferase diphtheria toxin-like 5	TRF1-interacting ankyrin-related ADP-ribose polymerase 1
protein poly-ADP-ribosyltransferase tankyrase-1	tankyrase I
tankyrase-1

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108845	Tenecteplase		≥95.0%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12418	Stenoparib	Inhibitor	≥98.0%	Phase 2

Pre-clinical Phase

Bioactive Molecules (50)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15147	XAV-939	Inhibitor	99.91%	Unkown
HY-12438	G007-LK	Inhibitor	99.24%	Unkown
HY-14443	XMD8-92	Inhibitor	99.67%	Unkown
HY-13990	NVP-TNKS656		99.66%	Unkown
HY-16910	WIKI4	Inhibitor	99.93%	Unkown
HY-147316	TP-5801	Inhibitor	99.69%	Unkown
HY-12975	AZ6102	Inhibitor	99.65%	Unkown
HY-13968	JW 55	Inhibitor	98.95%	Unkown
HY-15800A	CZC-25146	Inhibitor	99.10%	Unkown
HY-19351	MN-64	Inhibitor	99.61%	Unkown
HY-U00422	K-756	Inhibitor	99.25%	Unkown
HY-145267	OM-153	Inhibitor	99.59%	Unkown
HY-148063	DB0614		98.80%	Unkown
HY-123851	MSC2504877	Inhibitor	98.50%	Unkown
HY-15811	XMD8-87	Inhibitor	98.15%	Unkown
HY-101243	XMD16-5	Inhibitor	98.59%	Unkown
HY-143338	ART-IN-1	Inhibitor	98.91%	Unkown
HY-147316A	TP-5801 TFA	Inhibitor	99.34%	Unkown
HY-148061	DB1113		99.28%	Unkown
HY-121719	TIQ-A	Inhibitor	99.65%	Unkown
HY-126248	Tankyrase-IN-2	Inhibitor	99.06%	Unkown
HY-147886	PARP1-IN-11	Inhibitor	98.58%	Unkown
HY-148065	FMF-06-098-1		/	Unkown
HY-137849	RK-582	Inhibitor	/	Unkown
HY-100847	AZ0108	Inhibitor	/	Unkown
HY-108516	TC-E 5001	Inhibitor	/	Unkown
HY-117700	TNKS-IN-2	Inhibitor	/	Unkown
HY-12577	TNKS1/2-IN-1		/	Unkown
HY-12601	TNKS 22	Inhibitor	/	Unkown
HY-145111	TNK2-IN-1	Inhibitor	/	Unkown
HY-146336	PARP1/2/TNKS1/2-IN-1		/	Unkown
HY-152197	Tankyrase-IN-3	Inhibitor	/	Unkown
HY-152198	Tankyrase-IN-4	Inhibitor	/	Unkown
HY-153259	TNKS1/2-IN-2	Inhibitor	/	Unkown
HY-155246	PARP1-IN-15		/	Unkown
HY-156332	TNKS-2-IN-2	Inhibitor	99.47%	Unkown
HY-23338	TNKS-2-IN-1	Inhibitor	95.77%	Unkown
HY-RS14837	TNK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14838	TNK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14839	TNKS Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14840	Tnks Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14841	Tnks Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14842	TNKS1BP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14843	TNKS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14844	Tnks2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14845	TNKS2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W294889	OUL245	Inhibitor	/	Unkown
HY-118731	TNK-6123	Activator	/	Unkown
HY-153332	Tankyrase-IN-5	Inhibitor	/	Unkown
HY-15800	CZC-25146 hydrochloride	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tnks	NCBI	NCBI:8658

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