2. Cell Cycle/DNA Damage Epigenetics Stem Cell/Wnt
  3. PARP β-catenin
  4. WIKI4

WIKI4 is a potent tankyrase inhibitor with an IC50 of 26 nM for TNKS2. WIKI4 potently inhibits Wnt/β-catenin signaling and that its half-maximal response dose is 75 nM. WIKI4 mediates its effects on Wnt/β-catenin signaling by inhibiting the enzymatic activity of TNKS2. WIKI4 is cytotoxic to SCLC cells with an IC50 value of 0.02 μM.

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WIKI4 Chemical Structure

WIKI4 Chemical Structure

CAS No. : 838818-26-1

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Customer Review

Based on 4 publication(s) in Google Scholar

WIKI4 Related Antibodies

Top Publications Citing Use of Products

    WIKI4 purchased from MedChemExpress. Usage Cited in: Dig Dis Sci. 2018 Sep;63(9):2341-2350.  [Abstract]

    The expression of c-myc and Cyclin D1 is further decreased after adding β-catenin inhibitor (WIKI4) in mRNA level.

    WIKI4 purchased from MedChemExpress. Usage Cited in: Dig Dis Sci. 2018 Sep;63(9):2341-2350.  [Abstract]

    The expression of c-myc and Cyclin D1 is further decreased after adding β-catenin inhibitor (WIKI4) in protein level.

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    PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

    • Biological Activity

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    • Customer Review

    Description

    WIKI4 is a potent tankyrase inhibitor with an IC50 of 26 nM for TNKS2. WIKI4 potently inhibits Wnt/β-catenin signaling and that its half-maximal response dose is 75 nM. WIKI4 mediates its effects on Wnt/β-catenin signaling by inhibiting the enzymatic activity of TNKS2[1][2]. WIKI4 is cytotoxic to SCLC cells with an IC50 value of 0.02 μM[3].

    IC50 & Target[2]

    TNKS2

    26 nM (IC50)

    In Vitro

    WIKI4 (100 nM, 1 μM; 6 days; DLD1 cells) inhibits growth of DLD1 cells relative to DMSO controls in media containing low serum. WIKI4 inhibits expression of β-catenin target genes and cellular responses to Wnt/β-catenin signaling[1].
    WIKI4 (1 μM; 2 hours, 4 hours, 6 hours, or 24 hours; DLD1 cells) significantly increases the steady-state abundance of AXIN1 and AXIN2[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    WIKI4 Related Antibodies

    Cell Viability Assay[1]

    Cell Line: DLD1 cells
    Concentration: 100 nM, 1 μM
    Incubation Time: 6 days
    Result: Inhibited growth of DLD1 cells.

    Western Blot Analysis[1]

    Cell Line: DLD1 cells
    Concentration: 1 μM
    Incubation Time: 2 hours,4 hours,6 hours, or 24 hours
    Result: Significantly increased the steady-state abundance of AXIN1 and AXIN2.
    Molecular Weight

    521.59

    Formula

    C29H23N5O3S
    CAS No.
    Appearance

    Solid

    Color

    Off-white to light yellow

    SMILES

    O=C1N(CCCSC2=NN=C(C3=CC=NC=C3)N2C4=CC=C(OC)C=C4)C(C5=CC=CC6=CC=CC1=C56)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : 6.8 mg/mL (13.04 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.9172 mL 9.5861 mL 19.1721 mL
    5 mM 0.3834 mL 1.9172 mL 3.8344 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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    Purity & Documentation

    Purity: 99.93%

    COA (254 KB) LCMS (266 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.9172 mL 9.5861 mL 19.1721 mL 47.9304 mL
    5 mM 0.3834 mL 1.9172 mL 3.8344 mL 9.5861 mL
    10 mM 0.1917 mL 0.9586 mL 1.9172 mL 4.7930 mL
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    WIKI4 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    WIKI4838818-26-1WIKI 4WIKI-4PARPβ-cateninpoly ADP ribose polymerase Beta cateninInhibitorinhibitorinhibit

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