TNKS - tankyrase Gene

Homo sapiens

Also known as TIN1; ARTD5; PARPL; TINF1; TNKS1; pART5; PARP5A; PARP-5a

Gene ID: 8658 | Gene type: protein coding

About TNKS

Cytogenetic location: 8p23.1 Genomic coordinates (GRCh38): 8:9,555,912-9,782,346 (from NCBI)

This gene has 13 transcripts (splice variants), 1 gene allele, 279 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 8.6), brain (RPKM 7.0) and 25 other tissues.

Summary

Enables histone binding activity; pentosyltransferase activity; and zinc ion binding activity. Involved in several processes, including negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric; protein ADP-ribosylation; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; and protein ADP-ribosylation. Located in several cellular components, including chromosome, telomeric region; mitotic spindle pole; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

TNKS Products(3)

mRNA	Protein	Name
XM_011543846.4	XP_011542148.1	poly [ADP-ribose] polymerase tankyrase-1 isoform X2
NM_003747.3	NP_003738.2	poly [ADP-ribose] polymerase tankyrase-1
XM_011543845.4	XP_011542147.1	poly [ADP-ribose] polymerase tankyrase-1 isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables NAD+-protein ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	9822378	GOA
enables NAD+-protein poly-ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	9822378	GOA
enables histone binding	IPI IPI: Inferred from physical interaction	26373281	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9822378	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	18436240	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric	IMP IMP: Inferred from mutant phenotype	26373281	GOA
involved in negative regulation of telomere maintenance via telomere lengthening	IMP IMP: Inferred from mutant phenotype	25939383	GOA
involved in negative regulation of telomeric DNA binding	IDA IDA: Inferred from direct assay	9822378	GOA
involved in negative regulation of telomeric DNA binding	IMP IMP: Inferred from mutant phenotype	25939383	GOA
acts upstream of or within peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	17026964	GOA
acts upstream of or within peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	17026964	GOA
involved in positive regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	19759537	GOA
involved in positive regulation of telomere capping	IMP IMP: Inferred from mutant phenotype	25939383	GOA
involved in positive regulation of telomere maintenance via telomerase	IDA IDA: Inferred from direct assay	12782650	GOA
involved in positive regulation of telomere maintenance via telomerase	IMP IMP: Inferred from mutant phenotype	11739745	GOA
involved in positive regulation of telomere maintenance via telomere lengthening	IDA IDA: Inferred from direct assay	12782650	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19245366	GOA
involved in protein auto-ADP-ribosylation	IDA IDA: Inferred from direct assay	21478859	GOA
involved in protein localization to chromosome, telomeric region	IMP IMP: Inferred from mutant phenotype	15133513	GOA
involved in protein poly-ADP-ribosylation	IDA IDA: Inferred from direct assay	9822378	GOA
involved in protein poly-ADP-ribosylation	IMP IMP: Inferred from mutant phenotype	25939383	GOA
involved in protein polyubiquitination	IDA IDA: Inferred from direct assay	19759537	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	22864114	GOA
located in chromosome, telomeric region	IDA IDA: Inferred from direct assay	9822378	GOA
located in mitotic spindle pole	IDA IDA: Inferred from direct assay	16076287	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNKS Protein Structure

Ank_2

Ank

Ank_2

Ank

Ank_2

Ank_4

Ank_2

Ank_4

SAM_2

PARP

0
300
600
900
1200
1327 a.a.

Protein Preferred Names

Protein Names

poly [ADP-ribose] polymerase tankyrase-1

ADP-ribosyltransferase diphtheria toxin-like 5	TANK1
TNKS-1	TRF1-interacting ankyrin-related ADP-ribose polymerase 1
poly [ADP-ribose] polymerase 5A	protein poly-ADP-ribosyltransferase tankyrase-1
tankyrase I	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
tankyrase-1

TNKS Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TNKS	O95271	FNBP1	Homo sapiens	Q96RU3	Anti Tag CoIP	14596906
Intra	TNKS	O95271	FNBP1	Homo sapiens	Q96RU3	Y2H	14596906
Intra	TNKS	O95271	UBASH3B	Homo sapiens	Q8TF42	Validated Y2H	32296183
Intra	TNKS	O95271	TNKS1BP1	Homo sapiens	Q9C0C2	Pull Down	12080061
Cross	TNKS	O95271	Axin1	Mus musculus	O35625	Anti Tag CoIP	19759537
Intra	TNKS	O95271	DISC1	Homo sapiens	Q9NRI5	Y2H	17043677
Intra	TNKS	O95271	EPM2AIP1	Homo sapiens	Q7L775	Validated Y2H	32296183
Intra	TNKS	O95271	TERF1	Homo sapiens	P54274	Pull Down	12080061
Intra	TNKS	O95271	TERF1	Homo sapiens	P54274	Anti Tag CoIP	20696165
Intra	TNKS	O95271	ADPRS	Homo sapiens	Q9NX46	Validated Y2H	32296183
Intra	TNKS	O95271	HIF1AN	Homo sapiens	Q9NWT6	Enzymatic Study	21251231
Intra	TNKS	O95271	TCL1A	Homo sapiens	P56279	Validated Y2H	32296183
Intra	TNKS	O95271	OARD1	Homo sapiens	Q9Y530	Validated Y2H	32296183
Intra	TNKS	O95271	CENPJ	Homo sapiens	Q9HC77	Anti Tag CoIP	22699936
Intra	TNKS	O95271	CENPJ	Homo sapiens	Q9HC77	IF	22699936

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Chromosome 2q31.2 Deletion Syndrome

Cherubism

CRBM	Familial Benign Giant-Cell Tumor Of The Jaw
Familial Fibrous Dysplasia Of Jaw	Familial Multilocular Cystic Disease Of The Jaws

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108845	Tenecteplase		≥95.0%	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12418	Stenoparib	Inhibitor	≥98.0%	Phase 2
HY-147245	Basroparib	Inhibitor	98.49%	Phase 1

Pre-clinical Phase

Bioactive Molecules (50)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15147	XAV-939	Inhibitor	99.91%	Unkown
HY-12438	G007-LK	Inhibitor	99.24%	Unkown
HY-14443	XMD8-92	Inhibitor	99.67%	Unkown
HY-13990	NVP-TNKS656		99.66%	Unkown
HY-16910	WIKI4	Inhibitor	99.93%	Unkown
HY-147316	TP-5801	Inhibitor	99.69%	Unkown
HY-12975	AZ6102	Inhibitor	99.65%	Unkown
HY-13968	JW 55	Inhibitor	98.95%	Unkown
HY-15800A	CZC-25146	Inhibitor	99.10%	Unkown
HY-19351	MN-64	Inhibitor	99.61%	Unkown
HY-U00422	K-756	Inhibitor	99.25%	Unkown
HY-145267	OM-153	Inhibitor	99.59%	Unkown
HY-148063	DB0614		98.80%	Unkown
HY-123851	MSC2504877	Inhibitor	98.50%	Unkown
HY-15811	XMD8-87	Inhibitor	98.15%	Unkown
HY-148061	DB1113		99.28%	Unkown
HY-101243	XMD16-5	Inhibitor	98.59%	Unkown
HY-143338	ART-IN-1	Inhibitor	98.91%	Unkown
HY-147316A	TP-5801 TFA	Inhibitor	99.34%	Unkown
HY-126248	Tankyrase-IN-2	Inhibitor	99.06%	Unkown
HY-121719	TIQ-A	Inhibitor	99.65%	Unkown
HY-147886	PARP1-IN-11	Inhibitor	98.58%	Unkown
HY-148065	FMF-06-098-1		/	Unkown
HY-137849	RK-582	Inhibitor	/	Unkown
HY-100847	AZ0108	Inhibitor	/	Unkown
HY-108516	TC-E 5001	Inhibitor	/	Unkown
HY-117700	TNKS-IN-2	Inhibitor	/	Unkown
HY-12577	TNKS1/2-IN-1		/	Unkown
HY-12601	TNKS 22	Inhibitor	/	Unkown
HY-145111	TNK2-IN-1	Inhibitor	/	Unkown
HY-146336	PARP1/2/TNKS1/2-IN-1		/	Unkown
HY-152197	Tankyrase-IN-3	Inhibitor	/	Unkown
HY-152198	Tankyrase-IN-4	Inhibitor	/	Unkown
HY-153259	TNKS1/2-IN-2	Inhibitor	/	Unkown
HY-155246	PARP1-IN-15		/	Unkown
HY-156332	TNKS-2-IN-2	Inhibitor	99.47%	Unkown
HY-23338	TNKS-2-IN-1	Inhibitor	95.77%	Unkown
HY-RS14837	TNK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14838	TNK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14839	TNKS Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14840	Tnks Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14841	Tnks Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14842	TNKS1BP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14843	TNKS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14844	Tnks2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14845	TNKS2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W294889	OUL245	Inhibitor	/	Unkown
HY-118731	TNK-6123	Activator	/	Unkown
HY-153332	Tankyrase-IN-5	Inhibitor	/	Unkown
HY-15800	CZC-25146 hydrochloride	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TNKS	RGD	RGD:1308784
Felis catus	TNKS	VGNC	VGNC:66421
Mus musculus	TNKS	MGD	MGI:1341087
Canis familiaris	TNKS	VGNC	VGNC:47681
Macaca mulatta	TNKS	VGNC	VGNC:78601
Bos taurus	TNKS	VGNC	VGNC:36184
Others	TNKS	NCBI

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