2. Gene
  3. PSMC5 - proteasome 26S subunit, ATPase 5 Gene

PSMC5 - proteasome 26S subunit, ATPase 5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as S8; p45; RPT6; SUG1; SUG-1; TBP10; TRIP1; p45/SUG

Gene ID: 5705 | Gene type: protein coding

About PSMC5

Cytogenetic location: 17q23.3 Genomic coordinates (GRCh38): 17:63,827,431-63,832,019 (from NCBI)

This gene has 25 transcripts (splice variants), 222 orthologues, 5 paralogues and is associated with 1 phenotype. Ubiquitous expression in kidney (RPKM 58.1), brain (RPKM 54.9) and 25 other tissues.

Summary

The 26S Proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC Peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in Proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the Thyroid Hormone Receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

PSMC5 Products(2)

mRNA Protein Name
NM_001199163.2 NP_001186092.1 26S proteasome regulatory subunit 8 isoform 2
NM_002805.6 NP_002796.4 26S proteasome regulatory subunit 8 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
10816420 GOA
enables general transcription initiation factor binding IPI
IPI: Inferred from physical interaction
9173976 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9173976 GOA
enables thyrotropin-releasing hormone receptor binding IPI
IPI: Inferred from physical interaction
7870181 GOA
enables transcription factor binding IDA
IDA: Inferred from direct assay
7870181 GOA
Biological Process GO Annotation Evidence Reference Source
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
12110588 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
7870181 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
9927201 GOA
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
15885686 GOA
located in nucleus IDA
IDA: Inferred from direct assay
9927201 GOA
part of proteasome complex IDA
IDA: Inferred from direct assay
9464850 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMC5 Protein Structure

AAA

AAA: ATPase family associated with various cellular activities (AAA) (186 - 318)

  • 0
  • 100
  • 200
  • 300
  • 406 a.a.
Protein Preferred Names Protein Names

26S proteasome regulatory subunit 8

26S protease regulatory subunit 8

PSMC5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra PSMC5 P62195 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
Intra PSMC5 P62195 KRT40 Homo sapiens Q6A162
Y2H Array
31515488
Intra PSMC5 P62195 FOS Homo sapiens Q6FG41
Validated Y2H
25416956
Intra PSMC5 P62195 FOS Homo sapiens Q6FG41
Y2H Array
25416956
Intra PSMC5 P62195 BFSP2 Homo sapiens Q13515
Validated Y2H
32296183
Intra PSMC5 P62195 KRT38 Homo sapiens O76015
Y2H Array
29892012
Intra PSMC5 P62195 PAAF1 Homo sapiens Q9BRP4
Anti Tag CoIP
33961781
Intra PSMC5 P62195 PAAF1 Homo sapiens Q9BRP4
Anti Tag CoIP
19490896
Intra PSMC5 P62195 PAAF1 Homo sapiens Q9BRP4
Anti Tag CoIP
35271311
Intra PSMC5 P62195 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
32296183
Intra PSMC5 P62195 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
32296183
Intra PSMC5 P62195 TFIP11 Homo sapiens Q9UBB9
Y2H Array
32296183
Intra PSMC5 P62195 ERCC3 Homo sapiens P19447
Affinity Chrom
9173976
Intra PSMC5 P62195 ERCC3 Homo sapiens P19447
Anti Bait CoIP
9173976
Intra PSMC5 P62195 ESRRG Homo sapiens P62508-3
Validated Y2H
32296183
Intra PSMC5 P62195 BACH2 Homo sapiens Q9BYV9
Validated Y2H
32296183
Intra PSMC5 P62195 BACH2 Homo sapiens Q9BYV9
Y2H Array
32296183
Intra PSMC5 P62195 BACH2 Homo sapiens Q9BYV9
Y2H Prey Pooling
32296183
Intra PSMC5 P62195 THAP11 Homo sapiens Q96EK4
Anti Tag CoIP
33961781
Intra PSMC5 P62195 THAP11 Homo sapiens Q96EK4
Anti Tag CoIP
28514442
Intra PSMC5 P62195 RORB Homo sapiens Q92753-1
Validated Y2H
32296183
Intra PSMC5 P62195 RORB Homo sapiens Q92753-1
Y2H Array
32296183
Intra PSMC5 P62195 RORB Homo sapiens Q92753-1
Y2H Prey Pooling
32296183
Intra PSMC5 P62195 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
Intra PSMC5 P62195 KRT27 Homo sapiens Q7Z3Y8
Validated Y2H
32296183
Intra PSMC5 P62195 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
Intra PSMC5 P62195 PSMD2 Homo sapiens Q13200
Anti Bait CoIP
19490896
Intra PSMC5 P62195 PSMD2 Homo sapiens Q13200
Anti Tag CoIP
28514442
Intra PSMC5 P62195 PSMD2 Homo sapiens Q13200
Anti Tag CoIP
33961781
Intra PSMC5 P62195 PSMD2 Homo sapiens Q13200
Anti Tag CoIP
19490896
Intra PSMC5 P62195 PSMD2 Homo sapiens Q13200
Anti Tag CoIP
35271311
Intra PSMC5 P62195 PSMD2 Homo sapiens Q13200
Anti Bait CoIP
16763564
Intra PSMC5 P62195 PSMC6 Homo sapiens P62333
Validated Y2H
32296183
Intra PSMC5 P62195 PSMC6 Homo sapiens P62333
Anti Bait CoIP
16763564
Intra PSMC5 P62195 PSMC6 Homo sapiens P62333
Anti Tag CoIP
33961781
Intra PSMC5 P62195 PSMC6 Homo sapiens P62333
Y2H Array
32296183
Intra PSMC5 P62195 PSMC6 Homo sapiens P62333
Anti Tag CoIP
28514442
Intra PSMC5 P62195 PSMC6 Homo sapiens P62333
Anti Bait CoIP
19490896
Intra PSMC5 P62195 PSMC6 Homo sapiens P62333
Y2H Prey Pooling
32296183
Intra PSMC5 P62195 PSMC6 Homo sapiens P62333
Anti Tag CoIP
19490896
Intra PSMC5 P62195 PSMD4 Homo sapiens P55036
Anti Tag CoIP
33961781
Intra PSMC5 P62195 PSMD4 Homo sapiens P55036
Anti Tag CoIP
28514442
Intra PSMC5 P62195 PSMC2 Homo sapiens P35998
Anti Tag CoIP
28514442
Intra PSMC5 P62195 PSMC2 Homo sapiens P35998
Anti Tag CoIP
19490896
Intra PSMC5 P62195 PSMC2 Homo sapiens P35998
Anti Bait CoIP
19490896
Intra PSMC5 P62195 PSMC2 Homo sapiens P35998
Anti Bait CoIP
16763564
Intra PSMC5 P62195 PSMC2 Homo sapiens P35998
Anti Tag CoIP
33961781
Intra PSMC5 P62195 RORC Homo sapiens P51449
Y2H Prey Pooling
32296183
Intra PSMC5 P62195 RORC Homo sapiens P51449
Y2H Array
32296183
Intra PSMC5 P62195 PDCL Homo sapiens Q13371
MAPPIT
32296183
Intra PSMC5 P62195 PDCL Homo sapiens Q13371
Validated Y2H
25416956
Intra PSMC5 P62195 PDCL Homo sapiens Q13371
Y2H Prey Pooling
32296183
Intra PSMC5 P62195 PDCL Homo sapiens Q13371
Y2H Prey Pooling
25416956
Intra PSMC5 P62195 PDCL Homo sapiens Q13371
Validated Y2H
32296183
Intra PSMC5 P62195 PDCL Homo sapiens Q13371
Y2H Array
25416956
Intra PSMC5 P62195 PDCL Homo sapiens Q13371
Complementation
32296183
Intra PSMC5 P62195 PDCL Homo sapiens Q13371
Y2H Array
32296183
Intra PSMC5 P62195 PDCL Homo sapiens Q13371
Anti Tag CoIP
28514442
Intra PSMC5 P62195 SKA1 Homo sapiens Q96BD8
Y2H Prey Pooling
32296183
Intra PSMC5 P62195 SKA1 Homo sapiens Q96BD8
Validated Y2H
32296183
Intra PSMC5 P62195 SKA1 Homo sapiens Q96BD8
Y2H Array
32296183
Intra PSMC5 P62195 SKA1 Homo sapiens Q96BD8
Anti Tag CoIP
33961781
Intra PSMC5 P62195 SKA1 Homo sapiens Q96BD8
Anti Tag CoIP
28514442
Intra PSMC5 P62195 PSMC4 Homo sapiens P43686
Anti Tag CoIP
35271311
Intra PSMC5 P62195 PSMC4 Homo sapiens P43686
Anti Tag CoIP
33961781
Intra PSMC5 P62195 PSMC4 Homo sapiens P43686
Anti Bait CoIP
19490896
Intra PSMC5 P62195 PSMC4 Homo sapiens P43686
Anti Tag CoIP
19490896
Intra PSMC5 P62195 CFAP206 Homo sapiens Q8IYR0
Validated Y2H
32296183
Intra PSMC5 P62195 TNNI2 Homo sapiens P48788
Y2H Prey Pooling
32296183
Intra PSMC5 P62195 TNNI2 Homo sapiens P48788
Y2H Array
32296183
Intra PSMC5 P62195 KRT31 Homo sapiens Q15323
Validated Y2H
32296183
Intra PSMC5 P62195 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra PSMC5 P62195 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra PSMC5 P62195 PLEKHO1 Homo sapiens Q53GL0
Anti Tag CoIP
23032291
Intra PSMC5 P62195 PLEKHO1 Homo sapiens Q53GL0
Y2H
23032291
Intra PSMC5 P62195 PLEKHO1 Homo sapiens Q53GL0
Pull Down
23032291
Intra PSMC5 P62195 PLEKHO1 Homo sapiens Q53GL0
Anti Bait CoIP
23032291
Cross PSMC5 P62195 Camk2a Rattus norvegicus P11275
Anti Tag CoIP
20178748
Cross PSMC5 P62195 Camk2b Rattus norvegicus P08413
Anti Tag CoIP
20178748
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cockayne Syndrome

Cockayne'S Syndrome

Dwarfism-Retinal Atrophy-Deafness Syndrome

Neill-Dingwall Syndrome

Progeria-Like Syndrome

Progeroid Nanism

Cs
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11315 PSMC5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PSMC5 VGNC VGNC:69116
Mus musculus PSMC5 MGD MGI:105047
Macaca mulatta PSMC5 VGNC VGNC:81513
Rattus norvegicus PSMC5 RGD RGD:708376
Bos taurus PSMC5 VGNC VGNC:33459