SKA2 - spindle and kinetochore associated complex subunit 2 Gene

Homo sapiens

Also known as FAM33A

Gene ID: 348235 | Gene type: protein coding

About SKA2

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:59,109,857-59,155,186 (from NCBI)

This gene has 10 transcripts (splice variants) and 230 orthologues. Ubiquitous expression in brain (RPKM 9.5), thyroid (RPKM 8.8) and 25 other tissues.

Summary

Enables microtubule binding activity. Involved in several processes, including chromosome segregation; mitotic cell cycle; and regulation of microtubule polymerization or depolymerization. Located in spindle microtubule. Part of outer kinetochore. [provided by Alliance of Genome Resources, Apr 2022]

SKA2 Products(3)

mRNA	Protein	Name
NM_001100595.2	NP_001094065.1	spindle and kinetochore-associated protein 2 isoform 2
NM_001330399.2	NP_001317328.1	spindle and kinetochore-associated protein 2 isoform 3
NM_182620.4	NP_872426.1	spindle and kinetochore-associated protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables microtubule binding	IDA IDA: Inferred from direct assay	19289083	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17093495	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in attachment of mitotic spindle microtubules to kinetochore	IDA IDA: Inferred from direct assay	29487209	GOA
involved in mitotic metaphase chromosome alignment	IPI IPI: Inferred from physical interaction	28495837	GOA
involved in mitotic sister chromatid segregation	IMP IMP: Inferred from mutant phenotype	17093495	GOA
involved in regulation of microtubule polymerization or depolymerization	IDA IDA: Inferred from direct assay	19289083	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of SKA complex	IDA IDA: Inferred from direct assay	31804178	GOA
located in kinetochore	IPI IPI: Inferred from physical interaction	21633384	GOA
part of outer kinetochore	IDA IDA: Inferred from direct assay	17093495	GOA
located in spindle microtubule	IDA IDA: Inferred from direct assay	17093495	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

spindle and kinetochore-associated protein 2

family with sequence similarity 33, member A

SKA2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SKA2	Q8WVK7	IFT57	Homo sapiens	Q9NWB7	Validated Y2H	32296183
Intra	SKA2	Q8WVK7	SKA1	Homo sapiens	Q96BD8	Anti Tag CoIP	33961781
Intra	SKA2	Q8WVK7	SKA1	Homo sapiens	Q96BD8	Anti Bait CoIP	17093495
Intra	SKA2	Q8WVK7	SKA1	Homo sapiens	Q96BD8	Pull Down	19360002
Intra	SKA2	Q8WVK7	SKA1	Homo sapiens	Q96BD8	Anti Tag CoIP	17093495
Intra	SKA2	Q8WVK7	SKA1	Homo sapiens	Q96BD8	Y2H	17093495
Intra	SKA2	Q8WVK7	SKA1	Homo sapiens	Q96BD8	Anti Bait CoIP	19360002

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Mulibrey Nanism

MUL	Muscle-Liver-Brain-Eye Nanism
Pericardial Constriction And Growth Failure	Perheentupa Syndrome
Mulibrey Growth Disorder	Mulibrey Nanism Syndrome
Pericardial Constriction With Growth Failure	Nanism Mulibrey

Acute Poststreptococcal Glomerulonephritis

Post-Streptococcal Glomerulonephritis

Acute Post-Streptococcal Glomerulonephritis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12965	SKA2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SKA2	VGNC	VGNC:34644
Canis familiaris	SKA2	VGNC	VGNC:46194
Macaca mulatta	SKA2	VGNC	VGNC:104651
Mus musculus	SKA2	MGD	MGI:1913390
Rattus norvegicus	SKA2	RGD	RGD:1307084

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