Ticam1 - toll-like receptor adaptor molecule 1 Gene

Mus musculus

Also known as TRIF; TICAM-1

Gene ID: 106759 | Gene type: protein coding

About Ticam1

Summary

Predicted to enable protein kinase binding activity. Involved in several processes, including TRIF-dependent Toll-like Receptor signaling pathway; cellular response to oxidised low-density lipoprotein particle stimulus; and positive regulation of cytokine production. Acts upstream of or within several processes, including positive regulation of cytokine production; positive regulation of lymphocyte activation; and positive regulation of nitrogen compound metabolic process. Located in cytosol and mitochondrion. Is expressed in genitourinary system. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human TICAM1 (toll like receptor adaptor molecule 1). [provided by Alliance of Genome Resources, Apr 2022]

Ticam1 Products(1)

mRNA	Protein	Name
NM_174989.5	NP_778154.1	TIR domain-containing adapter molecule 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14517278	MGI
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	21441935	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of B cell activation	IMP IMP: Inferred from mutant phenotype	12855817	MGI
acts upstream of B cell proliferation	IMP IMP: Inferred from mutant phenotype	12855817	MGI
acts upstream of or within MyD88-independent toll-like receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12855817	MGI
involved in TRIF-dependent toll-like receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17658277	MGI
acts upstream of or within apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	12872135	MGI
involved in cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	17658277	MGI
involved in cellular response to oxidised low-density lipoprotein particle stimulus	IMP IMP: Inferred from mutant phenotype	20037584	MGI
acts upstream of chemokine production	IGI IGI: Inferred from genetic interaction	12855817	MGI
acts upstream of chemokine production	IMP IMP: Inferred from mutant phenotype	12855817	MGI
acts upstream of or within defense response to virus	IMP IMP: Inferred from mutant phenotype	12872135	MGI
acts upstream of interferon-beta production	IMP IMP: Inferred from mutant phenotype	12855817	MGI
acts upstream of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	12855817	MGI
acts upstream of or within lipopolysaccharide-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	12855817	MGI
acts upstream of or within macrophage activation involved in immune response	IMP IMP: Inferred from mutant phenotype	12872135	MGI
acts upstream of macrophage cytokine production	IDA IDA: Inferred from direct assay	12872135	MGI
acts upstream of macrophage cytokine production	IGI IGI: Inferred from genetic interaction	12872135	MGI
acts upstream of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	12855817	MGI
acts upstream of nitric oxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	12872135	MGI
acts upstream of or within positive regulation of B cell activation	IMP IMP: Inferred from mutant phenotype	12855817	MGI
acts upstream of or within positive regulation of B cell proliferation	IMP IMP: Inferred from mutant phenotype	12855817	MGI
acts upstream of or within positive regulation of NF-kappaB transcription factor activity	IGI IGI: Inferred from genetic interaction	12855817	MGI
acts upstream of or within positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	12855817	MGI
involved in positive regulation of autophagy	IMP IMP: Inferred from mutant phenotype	17658277	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IGI IGI: Inferred from genetic interaction	12855817	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	12855817	MGI
acts upstream of or within positive regulation of chemokine production	IGI IGI: Inferred from genetic interaction	12855817	MGI
acts upstream of or within positive regulation of chemokine production	IMP IMP: Inferred from mutant phenotype	12855817	MGI
involved in positive regulation of cytokine production involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	20037584	MGI
involved in positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	20037584	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20037584	MGI
acts upstream of or within positive regulation of interferon-beta production	IMP IMP: Inferred from mutant phenotype	12855817	MGI
acts upstream of or within positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	12855817	MGI
acts upstream of or within positive regulation of macrophage cytokine production	IDA IDA: Inferred from direct assay	12872135	MGI
acts upstream of or within positive regulation of macrophage cytokine production	IGI IGI: Inferred from genetic interaction	12872135	MGI
acts upstream of or within positive regulation of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	12855817	MGI
involved in positive regulation of myeloid dendritic cell cytokine production	IMP IMP: Inferred from mutant phenotype	21703541	MGI
acts upstream of or within positive regulation of natural killer cell activation	IMP IMP: Inferred from mutant phenotype	21059856	MGI
acts upstream of or within positive regulation of nitric oxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	12872135	MGI
acts upstream of or within positive regulation of protein binding	IDA IDA: Inferred from direct assay	19734906	MGI
acts upstream of or within positive regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	19734906	MGI
acts upstream of or within positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	12872135	MGI
acts upstream of or within positive regulation of tumor necrosis factor production	IGI IGI: Inferred from genetic interaction	12872135	MGI
acts upstream of or within positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	12855817	MGI
acts upstream of or within positive regulation of type I interferon production	IMP IMP: Inferred from mutant phenotype	12872135	MGI
acts upstream of or within regulation of protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	12872135	MGI
acts upstream of or within response to exogenous dsRNA	IDA IDA: Inferred from direct assay	12872135	MGI
acts upstream of or within response to exogenous dsRNA	IMP IMP: Inferred from mutant phenotype	12855817	MGI
involved in response to exogenous dsRNA	IMP IMP: Inferred from mutant phenotype	21703541	MGI
acts upstream of or within response to lipopolysaccharide	IGI IGI: Inferred from genetic interaction	12872135	MGI
acts upstream of or within response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	12855817	MGI
acts upstream of tumor necrosis factor production	IDA IDA: Inferred from direct assay	12872135	MGI
acts upstream of tumor necrosis factor production	IGI IGI: Inferred from genetic interaction	12872135	MGI
acts upstream of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	12855817	MGI
acts upstream of type I interferon production	IMP IMP: Inferred from mutant phenotype	12872135	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	21703541	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	21703541	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

TIR domain-containing adapter molecule 1

TIR domain-containing adapter protein inducing IFN-beta	TIR domain-containing adaptor inducing interferon-beta
toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta

Ticam1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Ticam1	Q80UF7	Btk	Mus musculus	P35991	Anti Tag CoIP	21441935
Intra	Ticam1	Q80UF7	Tbk1	Mus musculus	Q9WUN2	Anti Bait CoIP	22454496

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14517	TICAM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ticam1	NCBI	NCBI:148022

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