2. Gene
  3. Ttr - transthyretin Gene

Ttr - transthyretin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as prealbumin

Gene ID: 22139 | Gene type: protein coding

About Ttr

Chromosome 18: 20,798,337-20,807,378 forward strand.GRCm39:CM001011.3

This gene has 1 transcript (splice variant), 178 orthologues, 2 paralogues and is associated with 10 phenotypes. Biased expression in liver adult (RPKM 3655.3), liver E18 (RPKM 293.2) and 7 other tissues.

Summary

This gene encodes a carrier protein responsible for the transport of thyroid Hormones and retinol. The protein consists of a tetramer of identical subunits. Due to increased stability of the tetramer form of this encoded protein in mouse, compared to the human protein, this gene product has a reduced tendency to form amyloid fibrils. In humans, this protein binds beta-amyloid preventing its aggregation and providing a neuroprotective role in Alzheimer's disease. [provided by RefSeq, Mar 2010]

Ttr Products(1)

mRNA Protein Name
NM_013697.5 NP_038725.1 transthyretin precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
23105095 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ttr Protein Structure

TR_THY

TR_THY: smart00095 (26 - 146)

  • 0
  • 100
  • 147 a.a.
Protein Preferred Names Protein Names

transthyretin

Recombinant Ttr Proteins

Cat. No. Product Name Accession Purity
HY-P73580 Transthyretin/TTR Protein, Mouse (HEK293, His) P07309 (G21-N147) ≥95%

Related Agents

Approval
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14852 Tafamidis 99.89% Yes
HY-132609 Patisiran sodium 96.72% Unkown
HY-132608 Inotersen sodium 93.63% Unkown
HY-132589 Vutrisiran 96.37% Unkown
HY-14852A Tafamidis meglumine 99.79% Yes
HY-132589A Vutrisiran sodium 96.37% Unkown
HY-148089 Eplontersen Inhibitor / Unkown
HY-112974 Inotersen Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-109165A Acoramidis hydrochloride 98.70% Phase 3
HY-109165 Acoramidis 99.23% Phase 3
HY-132590 Revusiran / Phase 3
Pre-clinical Phase
Bioactive Molecules (18)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N1957 Gamma-Mangostin 99.91% Unkown
HY-153609 AS-Patisiran sodium Inhibitor 92.51% Unkown
HY-132590A Revusiran sodium Inhibitor 93.16% Unkown
HY-153577 WT-TTR inhibitor 1 Inhibitor 98.03% Unkown
HY-148089A Eplontersen sodium Inhibitor 96.92% Unkown
HY-113950 Dichlorophenyl-ABA ≥99.0% Unkown
HY-146137 Transthyretin-IN-1 / Unkown
HY-147366 RBP4 ligand-1 Inhibitor / Unkown
HY-14852S Tafamidis-d3 / Unkown
HY-155299 PITB Inhibitor / Unkown
HY-159658 TTR stabilizer 1 Modulator / Unkown
HY-161505 Transthyretin-IN-3 Inhibitor / Unkown
HY-P10615 Abz-YGGRASDQ-EDDnp / Unkown
HY-RS15238 TTR Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS15239 Ttr Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS15240 Ttr Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-126927 TTR stabilizer L6 Modulator / Unkown
HY-160612 Transthyretin-IN-2 Inhibitor / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990734 Coramitug Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ttr NCBI NCBI:7276
Macaca fascicularis Ttr NCBI NCBI:101864775
Rattus norvegicus Ttr NCBI NCBI:24856