2. Gene
  3. OARD1 - O-acyl-ADP-ribose deacylase 1 Gene

OARD1 - O-acyl-ADP-ribose deacylase 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TARG1; C6orf130; dJ34B21.3

Gene ID: 221443 | Gene type: protein coding

About OARD1

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:41,064,772-41,097,787 (from NCBI)

This gene has 16 transcripts (splice variants) and 240 orthologues. Ubiquitous expression in testis (RPKM 36.5), thyroid (RPKM 20.0) and 25 other tissues.

Summary

The protein encoded by this gene is a deacylase that can convert O-acetyl-ADP-ribose to ADP-ribose and acetate, O-propionyl-ADP-ribose to ADP-ribose and propionate, and O-butyryl-ADP-ribose to ADP-ribose and butyrate. The ADP-ribose product is able to inhibit these reactions through a competitive feedback loop. [provided by RefSeq, Jul 2016]

OARD1 Products(13)

mRNA Protein Name
NM_001329684.2 NP_001316613.1 ADP-ribose glycohydrolase OARD1 isoform a
NM_001329685.1 NP_001316614.1 ADP-ribose glycohydrolase OARD1 isoform a
NM_001329686.2 NP_001316615.1 ADP-ribose glycohydrolase OARD1 isoform a
NM_001329688.2 NP_001316617.1 ADP-ribose glycohydrolase OARD1 isoform a
NM_001329689.2 NP_001316618.1 ADP-ribose glycohydrolase OARD1 isoform b
NM_001329690.2 NP_001316619.1 ADP-ribose glycohydrolase OARD1 isoform c
NM_001329691.2 NP_001316620.1 ADP-ribose glycohydrolase OARD1 isoform c
NM_001329692.1 NP_001316621.1 ADP-ribose glycohydrolase OARD1 isoform c
NM_001329693.2 NP_001316622.1 ADP-ribose glycohydrolase OARD1 isoform c
NM_001329694.2 NP_001316623.1 ADP-ribose glycohydrolase OARD1 isoform d
NM_001329695.1 NP_001316624.1 ADP-ribose glycohydrolase OARD1 isoform d
NM_001329696.2 NP_001316625.1 ADP-ribose glycohydrolase OARD1 isoform d
NM_145063.4 NP_659500.1 ADP-ribose glycohydrolase OARD1 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ADP-ribosylglutamate hydrolase activity IDA
IDA: Inferred from direct assay
23474714 GOA
enables O-acetyl-ADP-ribose deacetylase activity IDA
IDA: Inferred from direct assay
21849506 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23481255 GOA
enables purine nucleoside binding IDA
IDA: Inferred from direct assay
21849506 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA damage response IMP
IMP: Inferred from mutant phenotype
23481255 GOA
involved in peptidyl-glutamate ADP-deribosylation IDA
IDA: Inferred from direct assay
23474714 GOA
involved in protein de-ADP-ribosylation IDA
IDA: Inferred from direct assay
23474714 GOA
involved in purine nucleoside metabolic process IDA
IDA: Inferred from direct assay
21849506 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nucleolus IDA
IDA: Inferred from direct assay
29712969 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
29712969 GOA
located in site of DNA damage IDA
IDA: Inferred from direct assay
23481255 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OARD1 Protein Structure

Macro

Macro: Macro domain (35 - 134)

  • 0
  • 100
  • 152 a.a.
Protein Preferred Names Protein Names

ADP-ribose glycohydrolase OARD1

O-acetyl-ADP-ribose deacetylase 1

OARD1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
OARD1 Q9Y530 TNKS Homo sapiens O95271
Y2H Prey Pooling
32296183
Intra
OARD1 Q9Y530 TNKS Homo sapiens O95271
Y2H Array
32296183
Intra
OARD1 Q9Y530 PARP10 Homo sapiens Q53GL7
Enzymatic Study
23481255
Intra
OARD1 Q9Y530 PARP1 Homo sapiens P09874
Enzymatic Study
23481255
Intra
OARD1 Q9Y530 PARP1 Homo sapiens P09874
Anti Tag CoIP
23481255
Intra
OARD1 Q9Y530 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra
OARD1 Q9Y530 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant OARD1 Proteins

Cat. No. Product Name Accession Purity
HY-P71658 OARD1 Protein, Human (Myc, His) Q9Y530 (A2-L152) ≥95%

Related Diseases

Diseases Alias
Arthrogryposis, Renal Dysfunction, And Cholestasis 1

Arc Syndrome

ARCS1

Arthrogryposis Renal Dysfunction Cholestasis Syndrome

Arthrogryposis-Renal Dysfunction-Cholestasis Syndrome

Arcs

Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome

Arthrogryposis, Renal Dysfunction, And Cholestasis

Arthrogryposis-Renal Dysfunction-Cholestasis

Arthrogryposis - Renal Dysfunction - Cholestasis

Arthrogryposis Multiplex Congenita, Renal Dysfunction, And Cholestasis

Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome 1

Arthrogryposis Renal Dysfunction And Cholestasis 1

Arthrogryposis With Renal Dysfunction And Cholestasis Syndrome

Arthrogryposis, Renal Dysfunction, Cholestasis, Type 1

Kidney Failure

Renal Insufficiency
Brachydactyly, Type A4

Brachymesophalangy Ii And V

Temtamy Type Brachydactyly

Brachydactyly Type A4

BDA4

Brachymesophalangy 2 And 5

Brachydactyly Temtamy Type

Brachydactyly, Temtamy Type
Eastern Equine Encephalitis

Eee

Neuroinvasive Eastern Equine Encephalitis Virus Infection

Eastern Equine Encephalomyelitis

Encephalomyelitis, Eastern Equine

Triple E

Eastern Equine Encephalitis Virus Infection

Neuroinvasive Eastern Equine Encephalitis Virus Disease

Eee - [Eastern Equine Encephalitis]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09726 OARD1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus OARD1 VGNC VGNC:32390
Felis catus OARD1 VGNC VGNC:102477
Canis familiaris OARD1 VGNC VGNC:44085
Mus musculus OARD1 MGD MGI:2146818
Rattus norvegicus OARD1 RGD RGD:1308299
Macaca mulatta OARD1 VGNC VGNC:75444
Others OARD1 NCBI