2. Gene
  3. JAZF1 - JAZF zinc finger 1 Gene

JAZF1 - JAZF zinc finger 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TIP27; ZNF802

Gene ID: 221895 | Gene type: protein coding

About JAZF1

Cytogenetic location: 7p15.2-p15.1 Genomic coordinates (GRCh38): 7:27,830,577-28,180,795 (from NCBI)

This gene has 9 transcripts (splice variants), 265 orthologues and is associated with 64 phenotypes. Broad expression in adrenal (RPKM 50.1), endometrium (RPKM 20.1) and 20 other tissues.

Summary

This gene encodes a nuclear protein with three C2H2-type zinc fingers, and functions as a transcriptional repressor. Chromosomal aberrations involving this gene are associated with endometrial stromal tumors. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized [provided by RefSeq, Jul 2008]

JAZF1 Products(1)

mRNA Protein Name
NM_175061.4 NP_778231.2 juxtaposed with another zinc finger protein 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15302918 GOA
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
15302918 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15302918 GOA
Cellular Component GO Annotation Evidence Reference Source
part of transcription repressor complex IDA
IDA: Inferred from direct assay
15302918 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

juxtaposed with another zinc finger protein 1

TAK1-interacting protein 27

JAZF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra JAZF1 Q86VZ6 FAM9B Homo sapiens Q8IZU0
Validated Y2H
32296183
Intra JAZF1 Q86VZ6 NR2C2 Homo sapiens P49116
Anti Tag CoIP
33961781
Intra JAZF1 Q86VZ6 NR2C2 Homo sapiens P49116
Anti Tag CoIP
35016035
Intra JAZF1 Q86VZ6 NR2C2 Homo sapiens P49116
Proximity Labelling
35016035
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Endometrial Stromal Sarcoma

Ess

Endometrial Stromal Sarcoma, High Grade

Undifferentiated Endometrial Sarcoma

Stromal Sarcoma Of The Corpus Uteri

Sarcoma Endometrial Stromal

Sarcoma, Endometrial Stromal

Undifferentiated Stromal Sarcoma
Endometrial Stromal Tumor

Endometrial Stromal Neoplasm

Endometrial Stromal Tumors
Endometrial Stromal Nodule
Vaginal Endometrial Stromal Sarcoma
Vagina Sarcoma

Sarcoma Of The Vagina

Vaginal Sarcoma
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Cellular Leiomyoma
Myxoid Leiomyosarcoma

Leiomyosarcoma, Myxoid
Ovarian Sex-Cord Stromal Tumor

Ovarian Sex Cord Tumor With Annular Tubules

Ovarian Sex Cord-Stromal Tumor

Stromal Tumor Of Ovary
Ossifying Fibromyxoid Tumor

Ossifying Fibromyxoid Tumour

Ossifying Fibromyxoma
Adenosarcoma

Mullerian Adenosarcoma
Atypical Polypoid Adenomyoma
Wolfram Syndrome 1

WFS1

Didmoad

Wfs

Diabetes Mellitus And Insipidus With Optic Atrophy And Deafness

Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness

Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Syndrome

Wolfram Syndrome
Cervical Adenosarcoma

Cervical Muellerian Adenosarcoma

Cervical Mullerian Adenosarcoma
Uterine Benign Neoplasm
Sarcomatosis
Reproductive Organ Benign Neoplasm
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Diabetes Mellitus

Diabetes
Maturity-Onset Diabetes Of The Young

MODY

Maturity Onset Diabetes Mellitus In Young

Mason-Type Diabetes

Mason Type Diabetes

Maturity Onset Diabetes Of The Young

Mody Syndrome

Diabetes Of The Young, Maturity-Onset
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07031 JAZF1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus JAZF1 RGD RGD:1589007
Canis familiaris JAZF1 VGNC VGNC:42182
Bos taurus JAZF1 VGNC VGNC:30372
Macaca mulatta JAZF1 VGNC VGNC:81626
Felis catus JAZF1 VGNC VGNC:80601
Mus musculus JAZF1 MGD MGI:2141450