NR2C2 - nuclear receptor subfamily 2 group C member 2 Gene

Homo sapiens

Also known as TR4; TAK1

Gene ID: 7182 | Gene type: protein coding

About NR2C2

Cytogenetic location: 3p25.1 Genomic coordinates (GRCh38): 3:14,947,583-15,049,273 (from NCBI)

This gene has 13 transcripts (splice variants), 224 orthologues and 11 paralogues. Ubiquitous expression in brain (RPKM 10.5), thyroid (RPKM 9.7) and 25 other tissues.

Summary

This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

NR2C2 Products(2)

mRNA	Protein	Name
NM_001291694.2	NP_001278623.1	nuclear receptor subfamily 2 group C member 2 isoform 2
NM_003298.5	NP_003289.2	nuclear receptor subfamily 2 group C member 2 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	9556573	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	10644740	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10644740	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9556573	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12486131	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10644740	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IPI IPI: Inferred from physical interaction	17974920	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9556573	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NR2C2 Protein Structure

zf-C4

Hormone_recep

0
100
200
300
400
500
596 a.a.

Protein Preferred Names

Protein Names

nuclear receptor subfamily 2 group C member 2

Nuclear hormone receptor TR4

Related Diseases

Diseases

Alias

Aging

Premature Aging

Syndrome With Premature-Aging

Branchiootorenal Syndrome 2

BOR2	Bor Syndrome 2
Branchiootorenal Dysplasia 2	Branchio-Oto-Renal Dysplasia 2
Branchio-Oto-Renal Syndrome Type 2	Branchiootorenal Syndrome, Type 2

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-118574	UBP141	Antagonist	/	Unkown
HY-RS09537	NR2C2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09538	NR2C2AP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NR2C2	RGD	RGD:3201
Felis catus	NR2C2	VGNC	VGNC:68549
Macaca mulatta	NR2C2	VGNC	VGNC:75509
Canis familiaris	NR2C2	VGNC	VGNC:43947
Mus musculus	NR2C2	MGD	MGI:1352466
Bos taurus	NR2C2	VGNC	VGNC:32236

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