CDHR3 - cadherin related family member 3 Gene

Homo sapiens

Also known as CDH28

Gene ID: 222256 | Gene type: protein coding

About CDHR3

Cytogenetic location: 7q22.3 Genomic coordinates (GRCh38): 7:105,963,264-106,036,432 (from NCBI)

This gene has 14 transcripts (splice variants), 115 orthologues and 33 paralogues. Biased expression in lung (RPKM 2.7), stomach (RPKM 0.9) and 10 other tissues.

Summary

Predicted to enable cadherin binding activity and calcium ion binding activity. Predicted to be involved in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell morphogenesis; and cell-cell junction organization. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

CDHR3 Products(2)

mRNA	Protein	Name
NM_001301161.2	NP_001288090.1	cadherin-related family member 3 isoform 2
NM_152750.5	NP_689963.2	cadherin-related family member 3 isoform 1 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	24241537	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDHR3 Protein Structure

Cadherin

0
200
400
600
800
885 a.a.

Protein Preferred Names

Protein Names

cadherin-related family member 3

cadherin-like protein 28

Related Diseases

Diseases

Alias

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Acute Asthma

Childhood-Onset Asthma

Childhood Asthma

Asthma Childhood

Otitis Media

Opsoclonus-Myoclonus Syndrome	OMS
Otitis Media, Susceptibility To	Kinsbourne Syndrome
Otitis Media, Chronic/Recurrent	Come/Rom
Ataxo-Opso-Myoclonus Syndrome	Dancing Eye Syndrome
Dancing Eye-Dancing Feet Syndrome	Oma Syndrome
Opsoclonus Myoclonus Syndrome	Opsoclonus-Myoclonus-Ataxia Syndrome
Poma Syndrome	Paraneoplastic Opsoclonus-Myoclonus
Paraneoplastic Opsoclonus-Myoclonus-Ataxia Syndrome	Opsoclonus Myoclonus
OM	{Otitis Media, Susceptibility To}
Infectious Otitis Media

T2-High Asthma

Type 2 High Endotype

Chronic Asthma

Common Cold

Acute Coryza	Acute Nasopharyngitis
Acute Rhinitis	Acute Viral Rhinopharyngitis
Nasopharyngitis - Acute	Nasopharyngitis, Acute
Rhino-Sinusitis	Rhinosinusitis
Common Colds	Acute Infective Rhinitis
Cold	Coryza
Head Cold	Infective Nasopharyngitis
Rhinopharyngitis	Acute Nasal Catarrh
Infective Rhinitis	Acute Nasopharyngeal Catarrh
Infective Nasopharyngitis Nos	Nasopharyngitis Nos
Epipharyngitis	Mucositis Nos
Inflammatory Disease Of Mucous Membrane	Mucosal Inflammation

Adult-Onset Severe Asthma

Acute Flaccid Myelitis

Bardet-Biedl Syndrome 1

BBS1	Bardet-Biedl Syndrome 1, Modifier Of
Bardet-Biedl Syndrome	BBS
Bardet-Biedl Syndrome, Type 1	Laurence-Moon-Bardet-Biedl Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02345	CDHR3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CDHR3	VGNC	VGNC:27110
Mus musculus	CDHR3	MGD	MGI:1916014
Canis familiaris	CDHR3	VGNC	VGNC:39039
Rattus norvegicus	CDHR3	RGD	RGD:1591286
Felis catus	CDHR3	VGNC	VGNC:69372

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