NEIL2 - nei like DNA glycosylase 2 Gene

Homo sapiens

Also known as NEH2; NEI2

Gene ID: 252969 | Gene type: protein coding

About NEIL2

Cytogenetic location: 8p23.1 Genomic coordinates (GRCh38): 8:11,769,710-11,787,345 (from NCBI)

This gene has 7 transcripts (splice variants), 114 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 14.3), brain (RPKM 9.4) and 24 other tissues.

Summary

This gene encodes a member of the Fpg/Nei family of DNA glycosylases. These glycosylases initiate the first step in base excision repair by cleaving oxidatively damaged Bases and introducing a DNA strand break via their abasic site lyase activity. This Enzyme is primarily associated with DNA repair during transcription and acts prefentially on cytosine-derived lesions, particularly 5-hydroxyuracil and 5-hydroxycytosine. It contains an N-terminal catalytic domain, a hinge region, and a C-terminal DNA-binding domain with helix-two-turn-helix and zinc finger motifs. This Enzyme interacts with the X-ray cross complementing factor 1 scaffold protein as part of a multi-protein DNA repair complex. A pseudogene of this gene has been identified. [provided by RefSeq, Mar 2017]

NEIL2 Products(8)

mRNA	Protein	Name
NM_001135746.3	NP_001129218.1	endonuclease 8-like 2 isoform a
NM_001135747.3	NP_001129219.1	endonuclease 8-like 2 isoform b
NM_001135748.3	NP_001129220.1	endonuclease 8-like 2 isoform c
NM_001349439.2	NP_001336368.1	endonuclease 8-like 2 isoform b
NM_001349440.2	NP_001336369.1	endonuclease 8-like 2 isoform b
NM_001349441.2	NP_001336370.1	endonuclease 8-like 2 isoform b
NM_001349442.2	NP_001336371.1	endonuclease 8-like 2 isoform a
NM_145043.4	NP_659480.1	endonuclease 8-like 2 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NEIL2 Protein Structure

Fapy_DNA_glyco

H2TH

0
100
200
300
332 a.a.

Protein Preferred Names

Protein Names

endonuclease 8-like 2

DNA glycosylase/AP lyase Neil2

NEIL2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NEIL2	Q969S2	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	NEIL2	Q969S2	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	NEIL2	Q969S2	LCN2	Homo sapiens	P80188	Y2H Prey Pooling	32296183
Intra	NEIL2	Q969S2	LCN2	Homo sapiens	P80188	Y2H Array	32296183
Intra	NEIL2	Q969S2	CDHR3	Homo sapiens	Q6ZTQ4	Y2H Array	32296183
Intra	NEIL2	Q969S2	CDHR3	Homo sapiens	Q6ZTQ4	Y2H Prey Pooling	32296183
Intra	NEIL2	Q969S2	MEOX1	Homo sapiens	P50221	Y2H Array	32296183
Intra	NEIL2	Q969S2	MEOX1	Homo sapiens	P50221	Validated Y2H	25416956
Intra	NEIL2	Q969S2	MEOX1	Homo sapiens	P50221	Y2H Prey Pooling	32296183
Intra	NEIL2	Q969S2	MEOX1	Homo sapiens	P50221	Y2H Array	25416956
Intra	NEIL2	Q969S2	PAX5	Homo sapiens	Q02548	Y2H Array	32296183
Intra	NEIL2	Q969S2	PAX5	Homo sapiens	Q02548	Y2H Prey Pooling	32296183
Intra	NEIL2	Q969S2	REL	Homo sapiens	Q04864	Validated Y2H	25416956
Intra	NEIL2	Q969S2	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	NEIL2	Q969S2	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	NEIL2	Q969S2	TRIM27	Homo sapiens	P14373	Y2H Array	25416956
Intra	NEIL2	Q969S2	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	NEIL2	Q969S2	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Intra	NEIL2	Q969S2	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	25416956
Intra	NEIL2	Q969S2	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
Intra	NEIL2	Q969S2	CRX	Homo sapiens	O43186	Y2H Prey Pooling	32296183
Intra	NEIL2	Q969S2	CRX	Homo sapiens	O43186	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Autosomal Dominant Adult-Onset Proximal Spinal Muscular Atrophy

Autosomal Dominant Adult-Onset Proximal Sma	Autosomal Dominant Late-Onset Spinal Muscular Atrophy, Finkel Type
Finkel Disease	Smafk
Adult-Onset Proximal Spinal Muscular Atrophy, Autosomal Dominant	Autosomal Dominant Adult Proximal Spinal Muscular Atrophy
Finkel Late-Adult Type Sma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09188	NEIL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NEIL2	MGD	MGI:2686058
Bos taurus	NEIL2	VGNC	VGNC:31989
Canis familiaris	NEIL2	VGNC	VGNC:43727
Rattus norvegicus	NEIL2	RGD	RGD:1312033
Macaca mulatta	NEIL2	VGNC	VGNC:75210
Felis catus	NEIL2	VGNC	VGNC:107353

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