2. Gene
  3. ADGRG3 - adhesion G protein-coupled receptor G3 Gene

ADGRG3 - adhesion G protein-coupled receptor G3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PB99; GPR97; PGR26

Gene ID: 222487 | Gene type: protein coding

About ADGRG3

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:57,665,629-57,689,378 (from NCBI)

This gene has 7 transcripts (splice variants), 271 orthologues and 42 paralogues. Biased expression in bone marrow (RPKM 59.0), appendix (RPKM 9.5) and 1 other tissue.

Summary

Predicted to enable G protein-coupled receptor activity. Involved in G protein-coupled receptor signaling pathway and regulation of cell migration. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

ADGRG3 Products(2)

mRNA Protein Name
NM_001308360.2 NP_001295289.1 adhesion G protein-coupled receptor G3 isoform 2
NM_170776.5 NP_740746.4 adhesion G protein-coupled receptor G3 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
22575658 GOA
involved in regulation of cell migration IMP
IMP: Inferred from mutant phenotype
24178298 GOA
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
22575658 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADGRG3 Protein Structure

GPS

GPS: GPCR proteolysis site, GPS, motif (212 - 255)

7tm_2

7tm_2: 7 transmembrane receptor (Secretin family) (268 - 517)

  • 0
  • 100
  • 200
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  • 400
  • 500
  • 549 a.a.
Protein Preferred Names Protein Names

adhesion G protein-coupled receptor G3

G protein-coupled receptor 97

Related Diseases

Diseases Alias
Vibratory Urticaria

Vibratory Angioedema

Dermodistortive Urticaria

VBU

Ddu

Angioedema, Vibratory
Polymicrogyria, Bilateral Frontoparietal

Bilateral Frontoparietal Polymicrogyria

BFPP

Cerebellar Ataxia With Neuronal Migration Defect
Congenital Epulis

Gingival Neoplasms

Congenital Epulides

Congenital Gingival Cell Tumor

Congenital Granular Cell Tumor

Neumann Tumor
Epulis

Epulides

Gingival Polyp

Polyp Of Gum
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00356 ADGRG3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ADGRG3 RGD RGD:1305674
Macaca mulatta ADGRG3 VGNC VGNC:69606
Canis familiaris ADGRG3 VGNC VGNC:37645
Mus musculus ADGRG3 MGD MGI:1859670
Bos taurus ADGRG3 VGNC VGNC:25667
Felis catus ADGRG3 VGNC VGNC:59635